Appendiceal cancer: the differential diagnosis of a clinical case

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Abstract

The primary appendiceal cancer is one of the rarest malignancies. Its counts for 0.5% of all colon cancer and does not exceed few bips in all surgically removed appendices. The disease does not have specific signs. It can imitate acute appendicitis, its complications, or a disease of uterine appendages. The appendiceal cancer is commonly diagnosed during pathomorphological investigation after surgery. A clinical case of a 58-yearold female patient with a tumor of the appendix is presented in the paper. Initially the tumor was thought to be an appendicular infiltrate. During the patient's second hospitalization a differential diagnosis between a uterine appendages tumor and appendicular mucocele was performed. The histological examination identified mucosal adenocarcinoma (G1) of the appendix with invasion into the ileum wall. With the full range of radiation diagnostics that provides additional information to clinical assessment and laboratory work-up it is challenging even for practicians to diagnose the disease. Despite the rare frequency of appendiceal cancer, it should be included into the list for differential diagnosis. The paper presents the basics of the differential diagnosis with special emphasis on the awareness of this disease. The knowledge of specifics of its pre-operative diagnosis could be useful to practitioners.

About the authors

G. A. Stashuk

Moscow Regional Research and Clinical Institute (MONIKI)

Email: stashukmoniki@mail.ru
ORCID iD: 0000-0003-1058-0611

Alina A. Stashuk – MD, PhD, Head of the Department of Roentgenology No. 2; Professor, Chair of Radiation Diagnostics, Postgraduate Training Faculty

61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Россия

S. E. Dubrova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: dubrova.sofya@gmail.com
ORCID iD: 0000-0001-8809-1629

Sofia E. Dubrova – MD, PhD, Radiologist, Department of Roentgenology; Assistant, Chair of Radiation Diagnostics, Postgraduate Training Faculty

61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Россия

D. Ya. Smirnova

Sergiyev Posad Regional Hospital

Author for correspondence.
Email: d-ya-sm@yandex.ru
ORCID iD: 0000-0002-0128-7977

Daria Ya. Smirnova – MD, Radiologist, Department of Roentgenology

62A Novouglichskoe shosse, Sergiуev Posad, Moscow Region, 141301, Russian Federation



Россия

References

  1. Karande GY, Chua WM, Yiin RSZ, Wong KM, Hedgire S, Tan TJ. Spectrum of computed tomography manifestations of appendiceal neoplasms: acute appendicitis and beyond. Singapore Med J. 2019;60(4):173–82. doi: 10.11622/smedj.2019035.
  2. Asare EA, Compton CC, Hanna NN, Kosinski LA, Washington MK, Kakar S, Weiser MR, Overman MJ. The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base. Cancer. 2016;122(2):213–21. doi: 10.1002/cncr.29744.
  3. Lousberg L, Collignon J, Detry O. Appendiceal neuroendrocrine neoplasms: incidentaloma or something we should worry about? Curr Opin Gastroenterol. doi: 10.1097/MOG.0000000000000597. Forthcoming 2019.
  4. Nakajima Y, Kajiwara A, Sakaki M, Otoyama Y, Nishihara S, Suzuki N, Usami T, Nakatani S, Wang T, Yoshida H. Primary appendiceal signet ring cell carcinoma: a case report. Nihon Shokakibyo Gakkai Zasshi. 2019;116(11):927–33. Japanese. doi: 10.11405/nisshoshi.116.927.
  5. Поддубская ЕВ, Комов ДВ, Хайленко ВА, Нечипай АМ, Цихисели ГР, Нечушкин МИ, Сущихина МЛ, Морозова СЮ. Рак червеобразного отростка. Вопросы диагностики и лечения. Вестник РОНЦ им. Н.Н. Блохина РАМН. 1992;3(1):50–5.
  6. Майстренко НА, Ромащенко ПН, Ягин МВ. Аппендикулярный инфильтрат: диагностика и лечебная тактика. Вестник хирургии имени И.И. Грекова. 2016;175(5): 57–62. doi: 10.24884/0042-4625-2016-175-5-57-62.
  7. Nebgen DR, Lu KH, Bast RC Jr. Novel Approaches to Ovarian Cancer Screening. Curr Oncol Rep. 2019;21(8):75. doi: 10.1007/s11912-019-0816-0.
  8. Хаджимба АС. Показания к диагностической лапароскопии на различных этапах лечения больных раком яичников. Сибирский онкологический журнал. 2016;15(6):61–5. doi: 10.21294/1814-4861-2016-15-6-61-65.

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Copyright (c) 2019 Stashuk G.A., Dubrova S.E., Smirnova D.Y.

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