No 29 (2013)
- Year: 2013
- Articles: 15
- URL: https://almclinmed.ru/jour/issue/view/2
- DOI: https://doi.org/10.18786/2072-0505-2013-29
Full Issue
SCIENTIFIC REVIEWS, LECTURES
PATHOGENIC MECHANISMS OF SEPTIC NEPHROPATHY OF THE RENAL TRANSPLANTS AND THE SEARCH FOR WAYS OF SOLVING THIS PROBLEM WITH SELECTIVE USE OF MODERN EXTRACORPOREAL METHODS
Abstract
The article presents analysis of the pathogenic mechanisms of septic renal transplant nephropathy and the search for ways to solve this problem with the use of modern selective extracorporeal methods which are the most promising methods to struggle with severe septic complications and gram-negative sepsis which is a mixed-selective adsorption of endotoxin.
METASTATIC CANCER OF THE STOMACH (WHAT'S NEW IN DRUG THERAPY)
Abstract
Based on the non-satisfactory results of the medicamental treatment of gastric cancer, the constant search is being carried out for new drugs with a sparing specter of side effects. Given the results of some investigations, it was assumed that Her-2-positive status of gastric cancer was associated with the aggressive disease course and unfavorable prognosis. According to publications data, clinical efficiency and safety of trastuzumab in combination with the first-line chemotherapy was assessed in patients with metastatic gastric cancer and Her-2 hypersecretion.
THE ROLE OF ENDOTOXIN IN DEVELOPMENT OF SUPPURATIVE-SEPTIC DISEASES AND METHODS OF ENDOTOXIN LEVEL DETERMINATION IN BLOOD
Abstract
The severity and duration of suppurative inflammation of different locations is directly dependent on the level of lipopolysaccharides (endotoxin) in blood. Detection of this value and its dynamics during therapy enables determination of the treatment tactics and its correction. Examination of endotoxin level in biological fluids is a necessary diagnostic component in the therapeutic-and-prophylactic institutions. Today, highly sensitive methods such as LAL-test in different modifications and MAP-test (method of activated particles) are widely practised.
THE DIFFICULTIES IN DIAGNOSTICS OF THE CHRONIC PYELONEPHRITIS
Abstract
The review of the literature includes the features of the clinical pyelonephritis course and the possibilities of the laboratory diagnostics of the disease with analysis of new medical methods of the urine investigation. The role of microscopic, serological, bacteriological, molecular-biological, and morphological investigation was demonstrated. Their diagnostic opportunities, informativeness, availability, simplicity, and economy of execution were shown in assessment of the disease stage and the control of the efficiency of treatment and prophylaxis of the chronic pyelonephritis.
ROLE OF HLA IN RENAL TRANSPLANT REJECTION
Abstract
It is known that the number of matches of the major histocompatibility complex antigens has a direct relationship with the duration of a renal transplant functioning. The lecture examines the role of HLA matching in presensitization of renal transplant recipients and de novo production of antibodies. Attention is also paid to non-HLA antibodies.
MODERN INVASIVE AND NON-INVASIVE DIAGNOSTIC TECHNOLOGIES AND THERAPEUTIC METHODS IN MEDICINE
ENDOVASCULAR TREATMENT OF CEREBRAL ARTERIOVENOUS MALFORMATION USING THREE-DIMENSIONAL NAVIGATION
Abstract
Our experience of the endovascular embolization of AVM with 3D-roadmapping convincingly showed that usage of this technique is possible and effective. In comparison with two-dimensional navigation, greater amount of radical operations were performed. Reduction of the time of catheterization of AVM-feeding arteries as well as the volume of required contrast agent was also observed.
GESTATION OF PATIENTS WITH EISENMENGER’S SYNDROME: IS IT ALWAYS CONTRAINDICATED?
Abstract
The management of gestation and labor in a patient with Eisenmenger’s syndrome due to multiple defects of inter-ventricular septum was described. The possibility of gestation prolongation in the patient with the said pathology was discussed, supporting clinical-and-laboratory and instrumental criteria of the objective patient’s condition were proposed being worked out collectively and based on the individual course features of the disease and gestation.
DETECTION OF OPTICAL DENSITY OF THE MACULAR PIGMENT IN SECONDARY GESTATION
Abstract
The article presents a new method to diagnose the pathology of macular pigment in repeatedly pregnant women with myopia differently dependent on the age as well as on both refraction and peripheral alterations in cases without clear symptoms when traditional ophthalmic examination doesn’t reveal any existing pathology.
EFFECT OF METFORMIN AND PYOGLITAZON ON THE RISK FACTORS OF CARDIOVASCULAR PATHOLOGY DIAGNOSED DURING SCREENING OF PATIENTS WITH TYPE 2 DIABETES MELLITUS
Abstract
Under assessment there was metformin and pyoglitazon effect on the risk factors of cardiovascular disease. During treatment of patients with screening-diagnosed type 2 diabetes mellitus, the following changes were noted: decreasing the levels of glycated hemoglobin, Willebrand factor and C-reactive protein, and increasing the level of HDL cholesterol. It was shown that 6-month-long therapy with metformin and pyoglItazon allowed significant improving glycemia control and influencing markers of cardiovascular risk in these patients.
PECULIARITIES OF CLINICAL COURSE OF DYSCIRCULATORY ENCEPHALOPATHY IN PATIENTS WITH ATRIAL FIBRILLATION
Abstract
The article is devoted to the peculiarities of clinical course of dyscirculatory encephalopathy in patients with non-valvular atrial fibrillation. Clinical-and-instrumental data were analyzed and compared between patients with dyscirculatory encephalopathy associated with atrial fibrillation and patients with dyscirculatory encephalopathy due to hypertension and cerebral atherosclerosis without rhythm disturbances. The studies conducted are indicative of the necessity of complex treatment for all patients with atrial fibrillation to predict cerebral stroke and vascular dementia.
ASSESSMENT OF THE RESIDUAL TUMOR IN PATIENTS WITH MULTIPLE MYELOMA BASED ON THE ANALYSIS OF THE FREE LIGHT CHAINS OF IMMUNOGLOBULINS IN BLOOD SERUM
Abstract
Efficiency of the multiple myeloma treatment with chemotherapy including bortezomib was assessed based on determination of the level of immunoglobulin free light chains in blood serum. The method enables estimation of changes in kinetic parameters of the residual tumor, detection of the disease course prognosis, and the choice of the optimal approach to the disease therapy.
SUBSTITUTION OF CONDYLAR PROCESS ENDOPROSTHESIS WITH VARIABLE HEAD HEIGHT FOR DEFECTS OF MANDIBULAR JOINT PROCESS IN CHILDREN AND TEENAGERS
Abstract
This paper presents a new method of endoprosthetics of the congenital and acquired defects of the TMJ in children and adolescents. The fundamental difference of the said endoprosthesis from that known in medicine is the ability to adjust the length of the mandibular condyle, both during surgery and postoperatively, using minimally invasive surgical techniques. The developed prosthesis of mandibular condyle allows correcting its length (height) with the growth of bone tissue and age of the patient, excluding the development of severe secondary facial bone deformations and the need for repeated surgery to replace the implant.
MEDICO-SOCIAL PROBLEMS AND QUESTIONS OF PUBLIC HEALTH CARE ORGANIZATION
THE PREVALENCE OF ARTERIAL HYPERTENSION AS ONE OF THE LEADING FACTORS OF THE STROKE RISK IN THE MOSCOW REGION ON THE EXAMPLE OF THE SMALL REGIONAL SETTLEMENT
Abstract
Analysis of the clinical-and-epidemiological parameters of the stroke was carried out and the prevalence of arterial hypertension was studied as one of the leading factors of stroke development among the residents of the small regional settlement of the Moscow Region. The epidemiological data obtained are indicative of the high stroke morbidity. A significant prevalence of the arterial hypertension was found in the population studied as well as an insufficient control and low understanding by patients of the necessity of regular taking antihypertensive drugs.
HOSPITAL MEDICAL HELP IN THE NEUROLOGICAL PRACTICE AS A MEDICAL-AND-ECONOMICAL PROBLEM
Abstract
In accordance with the goal and tasks of the research, we conducted clinical-and-economical analysis of pharmaco-therapy and medical services carried out in 2009, analysis of the cost of the disease typical treatment for the period of 2006-2010, and conducted evaluation of the cost of in-patient treatment in the neurological department of NOH Railroad Hospital in Astrakhan.