Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)3710.18786/2072-0505-2013-29-79-83SCIENTIFIC REVIEWS, LECTURESНАУЧНЫЕ ОБЗОРЫ, ЛЕКЦИИROLE OF HLA IN RENAL TRANSPLANT REJECTIONРОЛЬ СИСТЕМЫ HLA В ОТТОРЖЕНИИ ПОЧЕЧНОГО ТРАНСПЛАНТАТАVatazinA. V.ВатазинА. В.
Russian Federation
ZulkarnayevA. B.ЗулькарнаевА. Б.
Russian Federation
DmitrievaN. G.ДмитриеваН. Г.
Russian Federation
JakovchikO. N.ЯковчикО. Н.
Russian Federation
FedulkinaV. A.ФедулкинаВ. А.
Russian Federation
M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ)M.F. Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI)ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ151020132979831102201611022016Copyright ©; 2013, Vatazin A.V., Zulkarnayev A.B., Dmitrieva N.G., Jakovchik O.N., Fedulkina V.A.Copyright ©; 2013, Ватазин А.В., Зулькарнаев А.Б., Дмитриева Н.Г., Яковчик О.Н., Федулкина В.А.2013Vatazin A.V., Zulkarnayev A.B., Dmitrieva N.G., Jakovchik O.N., Fedulkina V.A.Ватазин А.В., Зулькарнаев А.Б., Дмитриева Н.Г., Яковчик О.Н., Федулкина В.А.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/37

It is known that the number of matches of the major histocompatibility complex antigens has a direct relationship with the duration of a renal transplant functioning. The lecture examines the role of HLA matching in presensitization of renal transplant recipients and de novo production of antibodies. Attention is also paid to non-HLA antibodies.

Известно, что количество совпадений по антигенам главного комплекса гистосовместимости имеет прямую связь с длительностью функционирования почечного трансплантата. В статье анализируется роль совпадения по HLA в предсенсибилизации реципиентов почечного трансплантата и в продукции антител de novo, а также уделяется внимание не-HLA-антителам.

major histocompatibility complexhuman leukocyte antigensrejectionantibodiesrenal transplantationглавный комплекс гистосовместимостилейкоцитарные антигены человекаотторжениеантителатрансплантация почки1.Абрамов В.Ю., Тарабарко Н.В., Мойсюк Я.Г. и др. Со-вместимость по общим HLA-DR-антигенам эффективно предупреждает раннюю утрату трансплантата почки // Вестн. транспл. искусств. органов. 2006. №5. С.12-17.2.Бикбов Б.Т., Томилина Н.А. Состояние заместительной терапии больных с хронической почечной недостаточностью в Российской Федерации в 1998-2009 гг. (Отчет по данным Российского регистра заместительной почечной терапии) // Нефрол. диал. 2011. №3. C.150-264.3.Данович Г.М. Трансплантация почки / пер. с англ. под ред. А.Г. Мойсюка. М.: ГЭОТАР-Медиа, 2013. С.54-138.4.Сушков А.И., Абрамов В.Ю., Мойсюк Я.Г. Роль предсуществующих и denovoантидонорских антител при трансплантации почки // Вестн. транспл. искусств. органов. 2012. №1. С.84-91.5.Arnol M., Prather J.C., Mittalhenkle A. et al. 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