Email this article The role of hereditary colorectal cancer registries in identification of high risk patients and treatment improvement
- Authors: Pikunov D.Y.1, Toboeva M.K.2, Tsukanov A.S.1
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Affiliations:
- State Scientific Centre of Coloproctology
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 46, No 1 (2018)
- Pages: 16-22
- Section: REVIEW ARTICLE
- URL: https://almclinmed.ru/jour/article/view/752
- DOI: https://doi.org/10.18786/2072-0505-2018-46-1-16-22
- ID: 752
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Abstract
Up to 10% of cases of sporadic colorectal cancer are considered to be related to hereditary genetic factors. The rates of colorectal cancer related to already identified genetic factors is about 5%. In the last decades, due to the development of comprehensive familial cancer registries and progress in genomics, clinical diagnostic criteria for specific hereditary syndromes have been proposed and multiple genes have been detected whose germ mutations increase the risk of neoplastic syndromes. Identification of individual patients and families with hereditary syndromes (familial adenomatous polyposis, Lynch syndrome, MYH-associated polyposis, hamartoma syndromes) may help to develop an effective strategy for monitoring and, as the results, for reduction of cancer incidence and improvement of survival. The aim of this literature review is to assess the influence of the registries of patients with hereditary types of colorectal cancer on its incidence and long-term treatment results.
About the authors
D. Yu. Pikunov
State Scientific Centre of Coloproctology
Author for correspondence.
Email: pikunov.gnck@mail.ru
Dmitriy Yu. Pikunov – MD, PhD, Research Associate, Department of Oncoproctology.
2 Salyama Adilya ul., Moscow, 123423, +7 (499) 199 25 54 Russian FederationM. Kh. Toboeva
Russian Medical Academy of Continuous Professional Education
Email: fake@neicon.ru
Margarita Kh. Toboeva – MD, Chair of Coloproctology.
2/1 Barrikadnaya ul., Moscow, 125993
Russian FederationA. S. Tsukanov
State Scientific Centre of Coloproctology
Email: fake@neicon.ru
Aleksey S. Tsukanov – MD, PhD, Head of Department of Clinical Genetic
Salyama Adilya ul., Moscow, 123423
Russian FederationReferences
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