Email this article SPECIFIC CHARACTERISTICS OF BRAIN METASTASIZING IN PATIENTS WITH LUMINAL SUBTYPE OF BREAST CANCER
- Authors: Balkanov A.S.1,2, Petrushkina N.N.1,2
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
- Issue: Vol 44, No 5 (2016)
- Pages: 635-639
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/454
- DOI: https://doi.org/10.18786/2072-0505-2016-44-5-635-639
- ID: 454
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Abstract
Background: More than half of female patients with breast cancer are diagnosed with a luminal subtype of the disease; however, specific characteristics of its metastases to the brain have been not well studied, unlike those of HER2 positive and triple negative subtypes. Aim: A comparative analysis of characteristics of metastatic brain lesions in patients with luminal breast cancer. Materials and methods: The time from surgery for breast cancer to the first recurrence and to metastatic brain lesions (assessed by contrast-enhanced MRI imaging) was measured in 41 patients with luminal subtype of breast cancer (median age, 49.5±9.6 years), depending on a diameter of the primary tumor and numbers of involved axillary lymph nodes. Results: The time interval to occurrence of brain metastases in luminal subtype of breast cancer is not associated with the size of the tumor. If≥4 axillary lymph nodes are involved (N2–3), brain metastases are identified much earlier (p<0.05) than in patients with N0–1 (34.5±23.9 months and 62.7±50 months, respectively). Neither the size nor the involvement of axillary lymph nodes has any impact on the rates of metastatic lesion to the brain during the first recurrence. Conclusion: Brain metastases occur at a much shorter time in those patients of luminal subtype of breast cancer who have metastases in≥4 axillary lymph nodes. Brain metastases develop in 50% of patients with the first recurrence of the luminal subtype of breast cancer.
About the authors
A. S. Balkanov
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Author for correspondence.
Email: andreybalkanov@yandex.ru
MD, PhD, Head of Department of Radiology Russian Federation
N. N. Petrushkina
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: andreybalkanov@yandex.ru
MD, Specialist in Radiation Therapy, Department of Radiology Russian Federation
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