AGGRESSIVE COURSE OF MULTIPLE SCLEROSIS IN AN ADOLESCENT: A CASE STUDY

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Abstract

In the last years there has been a  tendency towards a  shift of the onset of multiple sclerosis to childhood and adolescence. According to various estimates, its incidence at the age below 18 is in the range from 2 to 10%. The most characteristic for such patients is a  relapsing remitting course with a multi symptom onset. We present a "classic" clinical case of a female patient with an aggressive course of multiple sclerosis with the onset in the adolescence, discuss its assessment and management. 

About the authors

A. S. Kotov

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: alex-013@yandex.ru

MD, PhD, Professor, Chair of Neurology, Postgraduate Training Faculty; Head of Department of Pediatric Neurology

61/2 Shchepkina ul., Moscow, 129110

Tel.: +7 (495) 681 56 10

Russian Federation

Yu. V. Matyuk

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, Neurologist

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

M. S. Bunak

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

Junior Research Fellow, Department of Roentgenology

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

M. N. Borisova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Senior Research Fellow, Department of Pediatric Neurology

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

M. V. Panteleeva

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, PhD, Senior Research Fellow, Department of Pediatric Neurology

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

A. V. Shatalin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru

MD, Neurologist

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

References

  1. Ghezzi A, Banwell B, Boyko A, Amato MP, Anlar B, Blinkenberg M, Boon M, Filippi M, Jozwiak S, Ketelslegers I, Kornek B, Lim M, Lindstrom E, Nadj C, Neuteboom R, Rocca MA, Rostasy K, Tardieu M, Wassmer E, Catsman-Berrevoets C, Hintzen R. The management of multiple sclerosis in children: a European view. Mult Scler. 2010;16(10):1258– 67. doi: 10.1177/1352458510375568.
  2. Inaloo S, Haghbin S. Multiple sclerosis in children. Iran J Child Neurol. 2013;7(2):1–10.
  3. Ghezzi A. Therapeutic strategies in childhood multiple sclerosis. Ther Adv Neurol Disord. 2010;3(4):217–28. doi: 10.1177/1756285610371251.
  4. Шамова ТМ, Лебейко ТЯ, Гордеев ЯЯ. Рассеянный склероз у детей и подростков. Журнал Гродненского государственного медицинского университета. 2012;(1):99–101.
  5. Huppke B, Ellenberger D, Rosewich H, Friede T, Gärtner J, Huppke P. Clinical presentation of pediatric multiple sclerosis before puberty. Eur J Neurol. 2014;21(3):441–6. doi: 10.1111/ ene.12327.
  6. Bigi S, Banwell B. Pediatric multiple sclerosis. J Child Neurol. 2012;27(11):1378–83. doi: 10.1177/0883073812452784.
  7. Reinhardt K, Weiss S, Rosenbauer J, Gärtner J, von Kries R. Multiple sclerosis in children and adolescents: incidence and clinical picture – new insights from the nationwide German surveillance (2009–2011). Eur J Neurol. 2014;21(4):654–9. doi: 10.1111/ene.12371.
  8. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O'Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292–302. doi: 10.1002/ana.22366. 9.Ghezzi A, Amato MP, Capobianco M, Gallo P, Marrosu G, Martinelli V, Milani N, Milanese C, Moiola L, Patti F, Pilato V, Pozzilli C, Trojano M, Zaffaroni M, Comi G; Immunomodulatory Treatment of Early onset MS Group. Disease-modifying drugs in childhood-juvenile multiple sclerosis: results of an Italian co-operative study. Mult Scler. 2005;11(4):420–4. doi: 10.1191/1352458505ms1206oa.
  9. Ghezzi A, Amato MP, Annovazzi P, Capobianco M, Gallo P, La Mantia L, Marrosu MG, Martinelli V, Milani N, Moiola L, Patti F, Pozzilli C, Trojano M, Zaffaroni M, Comi G; ITEMS (Immunomodulatory Treatment of Early-onset MS) Group. Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: the Italian experience. Neurol Sci. 2009;30(3):193–9. doi: 10.1007/s10072-009-0083-1.
  10. Tenembaum SN, Segura MJ. Interferon beta- 1a treatment in childhood and juvenile-onset multiple sclerosis. Neurology. 2006;67(3): 511–3.
  11. Якушина ТИ, Лиждвой ВЮ, Василенко ИА, Андрюхина ОМ, Котов СВ. Дополнительные показатели для оценки эффективности терапии рассеянного склероза (предварительные данные). Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;113(2–2): 61–5.
  12. Ziemssen T, De Stefano N, Pia Sormani M, Van Wijmeersch B, Wiendl H, Kieseier BC. Optimizing therapy early in multiple sclerosis: An evidence-based view. Mult Scler Relat Disord. 2015;4(5):460–9. doi: 10.1016/j.msard.2015.07.007.
  13. Saguil A, Kane S, Farnell E. Multiple sclerosis: a primary care perspective. Am Fam Physician. 2014;90(9):644–52.

Copyright (c) 2016 Kotov A.S., Matyuk Y.V., Bunak M.S., Borisova M.N., Panteleeva M.V., Shatalin A.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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