A CASE OF PARANEOPLASTIC EROSIVE ULCERATIVE LICHEN PLANUS RUBRUM ASSOCIATED WITH A RECTAL ADENOCARCINOMA

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Abstract

The erosive ulcerative form of lichen planus rubrum localized on the oral mucosa is the most resistant to treatment from all types of the disease. It becomes malignant in 3% of cases and quite often is of a paraneoplastic character. We present a clinical case of an aggressive and resistant to treatment paraneoplastic erosive ulcerative lichen planus rubrum of the oral mucosa and the vermilion zone in a patient with polygonal papules typical for this dermatosis. The papules resolved after surgical removal of colorectal cancer tumor that was diagnosed at an early stage (adenocarcinoma in situ). We draw attention to the necessity of timely and careful assessment of patients with erosive ulcerative lichen planus rubrum for malignant neoplasms.

About the authors

V. A. Molochkov

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: yulia-molochkova@yandex.ru
MD, PhD, Professor, Mer- ited Scientist, Head of the Dermatovenereology and Dermato-oncology Department Russian Federation

M. A. Bobrov

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: yulia-molochkova@yandex.ru
MD, Research Fellow, Depart- ment of Pathological Anatomy Russian Federation

M. A. Amkhadova

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: yulia-molochkova@yandex.ru
MD, PhD, Professor of the Course of Surgical Stomatology and Implan- tology, Chair of Jaw and Face Surgery and Surgical Stomatology, Postgraduate Training Faculty Russian Federation

Yu. V. Molochkova

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: yulia-molochkova@yandex.ru
MD, PhD, Senior Research Fellow, Dermatovenereology and Dermato-oncology Department Russian Federation

M. S. Petrova

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: yulia-molochkova@yandex.ru
MD, Research Fellow, Dermato- venereology and Dermato-oncology Department Russian Federation

N. V. Kul'bachinskiy

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: yulia-molochkova@yandex.ru
MD, PhD Student, Course of Surgical Stomatology and Implantology, Chair of Jaw and Face Surgery and Surgical Stomatology, Postgraduate Training Faculty Russian Federation

References

  1. Молочков ВА, Сухова ТЕ, Молочкова ЮВ. Клинические особенности красного плоского лишая. Клиническая дерматология и венерология. 2013;11(4):34–43.
  2. Седова ЛА. Антиоксидантная терапия экс- судативно-гиперемической формы красного плоского лишая слизистой оболочки полости рта. Врач-аспирант. 2013;59(4): 104–10.
  3. Cheng S, Kirtschig G, Cooper S, Thornhill M, Leonardi-Bee J, Murphy R. Interventions for erosive lichen planus affecting mucosal sites. Cochrane Database Syst Rev. 2012;2:CD008092. doi: 10.1002/14651858.CD008092.pub2.
  4. Soria A, Agbo-Godeau S, Taïeb A, Francès C. Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases. Dermatology. 2009;218(1):22–5. doi: 10.1159/000172830.
  5. Simpson RC, Thomas KS, Leighton P, Murphy R. Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. Br J Dermatol. 2013;169(2):337–43. doi: 10.1111/bjd.12334.
  6. Pelisse M, Leibowitch M, Sedel D, Hewitt J. A new vulvovaginogingival syndrome. Plurimucous erosive lichen planus. Ann Dermatol Venereol. 1982;109(9):797–8.
  7. Селисский ГД, Измерова НИ, Хамаганова ИВ, Чикин ВР, Лепшокова ФВ, Нажмутдинова ДК. Патология слизистой оболочки полости рта и кожи, обусловленная побочным действием биотропных гигиенических парфюмер- но-косметических продуктов и стоматологических материалов (междисциплинарный проект). Российский журнал кожных и венерических болезней. 2009;(2):31–6.
  8. Carrozzo M. How common is oral lichen planus? Evid Based Dent. 2008;9(4):112–3. doi: 10.1038/sj.ebd.6400614.
  9. Машкиллейсон АЛ. Предрак красной каймы губ и слизистой оболочки полости рта. М.: Медицина; 1970. 271 с.
  10. Buajeeb W, Kraivaphan P, Pobrurksa C. Efficacy of topical retinoic acid compared with topical fluocinolone acetonide in the treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(1):21–5. doi: 10.1016/S1079-2104(97)90085-8.
  11. Carbone M, Arduino PG, Carrozzo M, Gandolfo S, Argiolas MR, Bertolusso G, Conrotto D, Pentenero M, Broccoletti R. Course of oral lichen planus: a retrospective study of 808 northern Italian patients. Oral Dis. 2009;15(3):235–43. doi: 10.1111/j.1601-0825.2009.01516.x.
  12. Samycia M, Lin AN. Efficacy of topical calcineurin inhibitors in lichen planus. J Cutan Med Surg. 2012;16(4):221–9.
  13. Elad S, Epstein JB, Yarom N, Drucker S, Tzach R, von Bültzingslöwen I. Topical immunomodulators for management of oral mucosal conditions, a systematic review; part I: calcineurin inhibitors. Expert Opin Emerg Drugs. 2010;15(4):713–26. doi: 10.1517/14728214.2010.528389.
  14. Арутюнов СД, Перламутров ЮН, Акинфиева ВБ, Брагина ЕЕ. Клинико-морфологическое обоснование комплексного лечения эрозивно-язвенной формы красного плоского лишая слизистой оболочки полости рта с применением биополимерных пленок «Галавит ПЛ». Dental Forum. 2005;(4):24–9.
  15. Глазкова ЮП, Перламутров ЮН, Корсунская ИМ, Терещенко АВ. Влияние комплексного лечения с использованием иммуносупрессивной терапии на цитокиновый статус сыворотки крови больных красным плоским лишаем слизистой оболочки полости рта и губ. Вестник последипломного медицинского образования. 2011;(2):24–6.
  16. Torti DC, Jorizzo JL, McCarty MA. Oral lichen planus: a case series with emphasis on therapy. Arch Dermatol. 2007;143(4):511–5. doi: 10.1001/archderm.143.4.511.
  17. Elewa R, Altenburg A, Zouboulis CC. Recalcitrant severe erosive cutaneous lichen planus treated with extracorporeal photopheresis monotherapy. Br J Dermatol. 2011;165(2):441– 3. doi: 10.1111/j.1365-2133.2011.10378.x.
  18. Cooper SM, Wojnarowska F. Influence of treatment of erosive lichen planus of the vulva on its prognosis. Arch Dermatol. 2006;142(3):289– 94. doi: 10.1001/archderm.142.3.289.
  19. Helm TN, Camisa C, Liu AY, Valenzuela R, Bergfeld WF. Lichen planus associated with neoplasia: a cell-mediated immune response to tumor antigens? J Am Acad Dermatol. 1994;30(2 Pt 1):219–24.
  20. Мейерхардт Дж, Сандерз М, ред. Рак толстой кишки. Пер. с англ. М.: Рид Элсивер, 2009. 186 с.
  21. Тимофеев ЮМ. Колоректальный рак: современные аспекты диагностики и лечения. Русский медицинский журнал. 2004;12(11):653–6.
  22. Iordache S, Săftoiu A, Ciurea T, Georgescu CV, Ghiluşi M. Predictive parameters for advanced neoplastic adenomas and colorectal cancer in patients with colonic polyps – a study in a tertiary medical centre in the South-West region of Romania. Rom J Morphol Embryol. 2006;47(3):239–43.
  23. Дворников АС, Рыбко ВА, Ковалева ОВ, Книжник АВ, Архипова КА, Каинов ЯА, Скрипкин ЮК, Зборовская ИБ. К вопросу о патогенезе и ранней диагностике пара- неопластических процессов в дерматологии. Вестник Российского государственного медицинского университета. 2007;(6): 50–5.

Copyright (c) 2016 Molochkov V.A., Bobrov M.A., Amkhadova M.A., Molochkova Y.V., Petrova M.S., Kul'bachinskiy N.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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