ACITRETIN IN THE TREATMENT OF GRZYBOWSKI TYPE ERUPTIVE KERATOACANTHOMA

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Abstract

The article describes a  case of successful treatment of multiple eruptive keratoacanthoma of Grzybowski in a 82-year old woman with concomitant advanced heart disease and chronic gastritis. The tumor was diagnosed in 1 of 256 patients with keratoacanthoma who attend our clinic, i.e. in 0,39% keratoacanthoma cases in general and in 0,96% among atypical keratoacanthomas. HLA-A2 gene characteristic for atypical keratoacanthomas was found in this patient. Acitretin was administered for 3 months at a  daily dose of 20 mg. The treatment resulted in a  full regression of the elements with residual areas of scarry atrophy and/or depigmentation. Flattening of the elements was obvious after 2 weeks. The patient tolerated the treatment well. 

About the authors

Zh. S. Kuntsevich

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.
Email: j_s_k@mail.ru

MD, PhD, Associate Professor, Chair of Dermatovenereology and Dermato-
oncology, Postgraduate Training Faculty

Russian Federation

Yu. V. Molochkova

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: j_s_k@mail.ru

MD, PhD, Senior Research Fellow, Dermatovenereology and Dermato-oncology Department

Russian Federation

M. A. Bobrov

Moscow Regional Research and Clinical Institute
(MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Email: j_s_k@mail.ru

MD, Research Fellow, Depart- ment of Pathological Anatomy

Russian Federation

A. N. Khlebnikova

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: j_s_k@mail.ru

MD, PhD, Professor, Chair of Skin and Venereal Diseases, Institute for Professional Education

Russian Federation

S. D. Dibirova

I.M. Sechenov First Moscow State Medical University; 8/2 Trubetskaya ul., Moscow, 119991, Russian Federation

Email: j_s_k@mail.ru

MD, PhD Student, Chair of Skin and Venereal Diseases, Institute for Professional
Education

Russian Federation

References

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Copyright (c) 2016 Kuntsevich Z.S., Molochkova Y.V., Bobrov M.A., Khlebnikova A.N., Dibirova S.D.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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