Almanac of Clinical MedicineAlmanac of Clinical Medicine2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)31310.18786/2072-0505-2016-44-1-96-102ACITRETIN IN THE TREATMENT OF GRZYBOWSKI TYPE ERUPTIVE KERATOACANTHOMAKuntsevichZh. S.<p>MD, PhD, Associate Professor, Chair of Dermatovenereology and Dermato- <br /> oncology, Postgraduate Training Faculty</p>j_s_k@mail.ruMolochkovaYu. V.<p>MD, PhD, Senior Research Fellow, Dermatovenereology and Dermato-oncology Department</p>j_s_k@mail.ruBobrovM. A.<p>MD, Research Fellow, Depart- ment of Pathological Anatomy</p>j_s_k@mail.ruKhlebnikovaA. N.<p>MD, PhD, Professor, Chair of Skin and Venereal Diseases, Institute for Professional Education</p>j_s_k@mail.ruDibirovaS. D.<p>MD, PhD Student, Chair of Skin and Venereal Diseases, Institute for Professional<br /> Education</p>j_s_k@mail.ruMoscow Regional Research and Clinical Institute
(MONIKI)61/2 Shchepkina ul., Moscow, 129110, Russian FederationI.M. Sechenov First Moscow State Medical University8/2 Trubetskaya ul., Moscow, 119991, Russian Federation15012016441961022506201625062016Copyright © 2016, Kuntsevich Z.S., Molochkova Y.V., Bobrov M.A., Khlebnikova A.N., Dibirova S.D.2016<p>The article describes a case of successful treatment of multiple eruptive keratoacanthoma of Grzybowski in a 82-year old woman with concomitant advanced heart disease and chronic gastritis. The tumor was diagnosed in 1 of 256 patients with keratoacanthoma who attend our clinic, i.e. in 0,39% keratoacanthoma cases in general and in 0,96% among atypical keratoacanthomas. HLA-A2 gene characteristic for atypical keratoacanthomas was found in this patient. Acitretin was administered for 3 months at a daily dose of 20 mg. The treatment resulted in a full regression of the elements with residual areas of scarry atrophy and/or depigmentation. Flattening of the elements was obvious after 2 weeks. The patient tolerated the treatment well. </p>eruptive keratoacanthoma of Grzybowskiaromatic retinoidsacitretinHLAantigenэруптивная кератоакантома типа Гржебовскиароматические ретиноидыацитретинHLA-антиген[1. Winkelmann RK, Brown J. Generalized eruptive keratoacanthoma. Report of cases. Arch Dermatol. 1968;97(6):615–23. doi: 10.1001/archderm.1968.01610120005001.][2. Rath S, Cowan BJ, Dolman PJ. Cicatricial ectropion in grzybowski type of multiple eruptive keratoacanthomas. Ophthal Plast Reconstr Surg. 2014;30(2):e42–3. doi: 10.1097/ IOP.0b013e318295f946.][3. Lloyd KM, Madsen DK, Lin PY. Grzybowski's eruptive keratoacanthoma. J Am Acad Dermatol. 1989;21(5 Pt 1):1023–4.][4. Kavanagh GM, Marshman G, Hanna MM. A case of Grzybowski's generalized eruptive keratoacanthomas. Australas J Dermatol. 1995;36(2):83–5. doi: 10.1111/j.1440- 0960.1995.tb00938.x.][5. Schwartz RA. The keratoacanthoma: a review. J Surg Oncol. 1979;12(4):305–17. doi: 10.1002/ jso.2930120404.][6. Беренбейн БА, Студницин АА, ред. Дифференциальная д и а г н о с т и к а кожных болезней. М.: Медицина; 1989. 672 с.][7. Chapman RS, Finn OA. Carcinoma of the larynx in two patients with keratoacanthoma. Br J Dermatol. 1974;90(6):685–8. doi: 10.1111/ j.1365-2133.1974.tb06698.x.][8.Grine RC, Hendrix JD, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski: response to cyclophosphamide. J Am Acad Dermatol. 1997;36(5 Pt 1):786–7. doi: 10.1016/ S0190-9622(97)80349-0.][9.Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol. 2014;53(2):131–6. doi: 10.1111/ijd.12318. 10. Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S. Generalized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol. 2000;142(4):800–3. doi: 10.1046/j.1365-2133.2000.03430.x.][11.Oakley A, Ng S. Grzybowski's generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol. 2005;46(2):118–23. doi: 10.1111/j.1440- 0960.2005.00157.x.][12. Молочков ВА, Кунцевич ЖС, Бобров МА, Дибирова СА. Эруптивная кератоакантома типа Гржебовски. Альманах клинической медицины. 2014;34:36–41.]