POLYMORPHISM OF CHRONIC GLOMERULONEPHRITIS ASSOCIATION WITH ADPRT1 GENE VAL762ALA

Cover Page


Cite item

Full Text

Abstract

Association of polymorphic ADPRT1 gene Val762Ala marker, encoding poly(ADP-ribose)polymerase-l, with the development, course and progress of chronic glomerulonephritis was revealed during investigation. The risk of the chronic glomerulonephritis development is higher in patients-carriers of Val-allele and Val/Val-genotype and lower in those with Ala-allele and Ala/Ala-genotype.

About the authors

E. S. Kamyshova

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: fake@neicon.ru
Россия

M. Yu. Shvetsov

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru
Россия

A. E. Shestakov

Clinicodiagnostic Laboratory FimedLab

Email: fake@neicon.ru
Россия

I. M. Kutyrina

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru
Россия

V. V. Nosikov

State Research Institute of Genetics and Selection of Industrial Microorganisms GNIIGENETIKA

Email: fake@neicon.ru
Россия

References

  1. Боброва Л.А., Козловская Н.Л., Шкарупо В.В. и др. Влияние генетической формы тромбофилии на клинико-морфологические проявления и характер течения хронического гломерулонефрита//Нефрол. диал. 2010. №1. С.25-33.
  2. Новожилова А.П., Плужников H.H., Новиков B.C. Механизмы клеточной гибели//Программированная клеточная смерть/под ред. B.C. Новикова. СПб.: Наука, 1996. С.9-29.
  3. Суханова М. В., Лаврик О. И., Ходырева С.Н. Поли(АDР-рибозо)полимераза 1 -регулятор белково-нуклеиновых взаимодействий в процессах, возникающих при генотоксическом воздействии//Молекул. биол. 2004. Т.38. С.5834-5847.
  4. Cesarone C.F., Scarabelli L., Scovassi I. et al. Changes in activity and mRNA levels of poly(ADP-ribose) polymerase during rat liver regeneration//Biochim. Biophys. Acta. 1990. V.1087. P.241-246.
  5. Dantzer F., Schreiber V., Niedergant C. et al. Involvement of poly(ADP-ribose)polymerase in base excision repair//Biochimie. 1999. V.81. P.69-75.
  6. Figueroa J.D., Maiats N., Real F.X. et al. Genetic variation in the base excision repair pathway and bladder cancer risk//Hum. Genet. 2007. V.121. P.233-242.
  7. Grande J.P. Mechanisms of progression of renal damage in lupus nephritis: pathogenesis of renal scarring//Lupus. 1998. No.7. P.604-610.
  8. Gwinner W., Grone H.J. Role of reactive oxygen species in glomerulonephritis//Nephrol. Dial. Transplant. 2000. V.15. P.1127-1132.
  9. Hao B., Wang H., Zhou K. et al. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma//Cancer Res. 2004. V.64. P.4378-4384.
  10. Hunley T.E., Julian B.A., Phillips J.A. et al. Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy//Kidney Int. 1996. V.49. P.571-577.
  11. Li F., Szaby C., Pacher P., Southan G.J. et al. Evaluation of orally active poly(ADP ribose) polymerase inhibitor in streptocin-diabetic rat model of early peripheral neuropathy//Diabetologia. 2004. V.47. P.710-717.
  12. Lockett K.L., Hall M.C. Xu J. et al. The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function//Cancer Res. 2004. V.64. P.6344-6348.
  13. Lovati E., Richard A., Frey B. et al. Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease 11 Kidney Int. 2001. V.60. P.46-54.
  14. Meisterernst M., Stelzer G., Roeder R.G. Poly(ADP-ribose)polymerase enhances activator-dependent transcription in vitro//Proc. Natl. Acad. Sei. 1997. V.94. P.2261-2265.
  15. Minchenko A.G., Stevens M.J., White L. et al. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP ribose) polymerase activation//FASE В J. 2003. V.17. P.1514-1516.
  16. Pacher P., Liaudet L., Bai P. et al. Activation of poly (ADP ribose) polymerase contributes to the development of doxorubicin-induced heart failure//J. Pharmacol. Exp. Ther. 2002. V.300. P.862-867.
  17. Prasad P., Tiwari A.K., Kumar K.M. et al. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes//BMC Med. Genet. 2010. V.U. P.52.
  18. Song J., Narita I., Goto S. et al. Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy//J. Med. Genet. 2003. V.40. P.372-376.
  19. Szaby E., Kern T.S., Virag L. et al. Evidence for poly(ADP ribose) polymerase activation in the diabetic retina//FASEB J. 2001. V.15. P.A942.
  20. Szaby G., Bahrle S., Stumpf N. et al. Poly(ADP ribose) polymerase inhibition reduces reperfusion injury after heart transplantation//Circ. Res. 2002. V.90. P.100-106.
  21. Wang Y., Kikuchi S., Suzuki H. et al. Endothelial nitric oxide synthase gene polymorphism in intron 4 affects on the progression of renal failure in non-diabetic renal disease//Nephrol. Dial. Transplant. 1999. V.14. P.2898-2902.
  22. Zhang Q., Li Y., Li X. et al. PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population//Мої. Biol. Rep. 2009. V.36. P.1461-1467.
  23. Zhang X., Miao X., Liang G. et al. Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer//Cancer Res. 2005. V.65. P.722-726.
  24. Zingarelli B., Salzman A.L., Szaby C. Genetic disruption of poly(ADP ribose)synthetase inhibits the expression of P-selectine and intercellular adhesion molecule-1 in myocardial ischemia-reperfusion injury//Circ. Res. 1998. V.83. P.85-94.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Kamyshova E.S., Shvetsov M.Y., Shestakov A.E., Kutyrina I.M., Nosikov V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies