Email this article MONITORING OF OPHTHALMOLOGICAL INDICATORS IN PATIENTS WITH MULTIPLE SCLEROSIS
- Authors: Andryukhina O.M.1, Ryabtseva A.A.1, Kotov S.V.1, Yakushina T.I.1, Kuchina N.V.1
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- Issue: No 36 (2015)
- Pages: 53-58
- Section: INFLAMMATORY AND DEGENERATIVE EYE DISEASES
- URL: https://almclinmed.ru/jour/article/view/221
- DOI: https://doi.org/10.18786/2072-0505-2015-36-53-58
- ID: 221
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Abstract
Background: According to the literature data, more than 70% of patients diagnosed with multiple sclerosis with disease duration > 5 years and absence of retrobulbar neuritis, have visual analyzer involvement manifested by decreased thickness of peripapillary nervous fibers.
Aim: To assess interrelations between retinal/optic nerve changes and clinical signs of multiple sclerosis; to estimate prognostic value of optic coherence tomography in the monitoring of patients with multiple sclerosis.
Materials and methods: We studied 132 eyes of 66 patients (41 women, 62.12%, and 25 men, 37.8%, age 20–57 years old) with verified diagnosis of relapsing-remitting multiple sclerosis. All patients underwent routine ophthalmological examination and optical coherence tomography every 3 months during 2 years.
Results: Significant correlations were demonstrated between disability severity (Expanded Disability Status Scale, EDSS) and changes of total thickness of peripapillary nervous fibers (r = -0.362, p = 0.042), mean thickness of superior temporal peripapillary nerve fibers (r = -0.373, p = 0.046), mean thickness of inferotemporal peripapillary nerve fibers (r = -0.504, p = 0.005), optic disc volume (r = -0.645, p = 0.001), total retinal thickness at the posterior pole of the eyeball (r = -0.470, p = 0.010), and total retinal volume (r = -0.453, p = 0.012). Demonstrated relations were independent of the history of retrobulbar neuritis.
Conclusion: Changes of visual analyzer demonstrated in optical coherence tomography reflect the severity of diffuse neurodegenerative process in the brain and correlate well with disability and disease progression.
About the authors
O. M. Andryukhina
Moscow Regional Research and Clinical Institute (MONIKI)
Author for correspondence.
Email: a-olya86@mail.ru
Junior Research Associate, Ophthalmology Department
Russian FederationA. A. Ryabtseva
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
MD, PhD, Professor, Chief of the Ophthalmology Department
Russian FederationS. V. Kotov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
MD, PhD, Professor, Chief of the Neurology Department, Postgraduate Medical School
Russian FederationT. I. Yakushina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
PhD, Senior Research Associate, Neurology Department
Russian FederationN. V. Kuchina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Fellow, Neurology Department, Postgraduate Medical School
Russian FederationReferences
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