Immunological aspects of determination of an adequate biological treatment sequence for inflammatory bowel diseases: the expert board statement (St. Petersburg, May 22, 2021)

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Abstract

On May 22, 2021, the Expert Board met in St. Petersburg to discuss their position on immunological aspects of determination of an adequate biological treatment sequence for inflammatory bowel diseases (IBD). The Expert Board aimed at discussion of current strategies, development of a consensus on determination of an adequate biological treatment sequence for IBD. The main topics of the agenda were the contribution of immune system to the pathophysiology of Crohn's disease, ulcerative colitis and their complications, efficacy of genetically engineered biological agents (GEBA) at various stages of IBD management. Participation of the leading Russian experts in IBD, as well as involvement of other specialties, made it possible to consider the topic by a multidisciplinary team, with an in-depth analysis of IBD pathophysiology, to better understand the course of the disease in some contradictory situation, for instance, when clinical remission is not associated with an endoscopically confirmed remission. One of the expected effects of this Expert Board meeting would be an improvement of GEBA administration in clinical practice, mostly due to the modification of clinical guidelines. This would ascertain and confirm the algorithms for GEBA administration for IBD, including the optimal treatment sequence depending on an agent’s mechanism of action and the patient profile. The clarification of the optimal GEBA sequence in the clinical guidelines could lead to more frequent GEBA administration in local medical clinics and institutions in the regions, where GEBA are used insufficiently due to little experience and absence of their precise positioning in the clinical guidelines.

About the authors

E. A. Belousova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: eabelous@yandex.ru
ORCID iD: 0000-0003-4523-3337

Elena A. Belousova – MD, PhD, Professor, Head of Department of Gastroenterology; Head of Chair of Gastroenterology, Postgraduate Training Faculty

61/2–9 Shchepkina ul., Moscow, 129110

 

Россия

I. G. Kozlov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

Ivan G. Kozlov – MD, PhD, Professor, Head of Laboratory of Experimental and Clinical PharmacologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology; Professor, Chair of Medicines Organization and Management, Institute of Professional Education  I.M. Sechenov First Moscow State Medical University

1 Samory Mashela ul., Moscow, 117198, 

8/2 Trubetskaya ul., Moscow, 119991

Россия

D. I. Abdulganieva

Kazan State Medical University

Email: diana_s@mail.ru
ORCID iD: 0000-0001-7069-2725

Diana I. Abdulganieva – MD, PhD, Professor, First Vicerector, Head of Chair of Hospital Therapy 

49 Butlerova ul., Kazan, 420012

Россия

O. P. Alexeeva

Privolzhsky Research Medical University;
Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: fake@neicon.ru
ORCID iD: 0000-0002-1475-6584

Olga P. Alexeeva – MD, PhD, Professor, Chair of Hospital Therapy Privolzhsky Research Medical University; Director, Federal Gastroenterological Center of Povolzhye Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

10/1 Minina i Pozharskogo ploshchad', Nizhny Novgorod, 603005, 

190 Rodionova ul., Nizhny Novgorod, 603126

 

Россия

I. V. Gubonina

Military Medical Academy named after S.M. Kirov

Email: giv70@bk.ru
ORCID iD: 0000-0002-6302-7767

Irina V. Gubonina – MD, PhD, Associate Professor, 2nd Therapy Chair of Postgraduate Education 

6А Akademika Lebedeva ul., Saint Petersburg, 194044

Россия

A. A. Lishchinskaya

The Loginov Moscow Clinical Scientific Center

Email: fake@neicon.ru
ORCID iD: 0000-0001-7891-2702

Albina A. Lishchinskaya – MD, PhD, Gastroenterologist, Department of Inflammatory Bowel Diseases 

86–6 Entuziastov shosse, Moscow, 111123

Россия

L. V. Tarasova

I.N. Ulianov Chuvash State University;
Republican Clinical Hospital of Chuvashia

Email: fake@neicon.ru

Larisa V. Tarasova – MD, PhD, Professor, Head of Chair of Intermediate Level and Hospital Therapy, Medical Faculty I.N. Ulianov Chuvash State University; Head of Department of Gastroenterology, Head of Republican Gastroenterological Center Republican Clinical Hospital of Chuvashia

15 Moskovskiy prospekt, Cheboksary, 428015, Russian Federation;

9 Moskovskiy prospekt, Cheboksary, 428018, Russian Federation

Россия

E. Yu. Chashkova

Irkutsk Scientific Centre of Surgery and Traumatology

Email: elenachash1027@yandex.ru
ORCID iD: 0000-0002-7953-6523

Elena Yu. Chashkova – MD, PhD, Coloproctologist, Leading Research Fellow, Head of Laboratory of Reconstructive Surgery, Scientific Department of Clinical Surgery 

1 Bortsov Revolyutsii ul., Irkutsk, 66400

Россия

M. V. Shapina

National Medical Research Centre for Coloproctology named after A.N. Ryzhikh

Email: shapina.mv@yandex.ru
ORCID iD: 0000-0003-1172-6221

Marina V. Shapina – MD, PhD, Head of Department of Research in Inflammatory and Functional Bowel Disorders 

2 Salyama Adilya ul., Moscow, 123423

Россия

O. S. Shifrin

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

Oleg S. Shifrin – MD, PhD, Professor, Head of Department of Chronic Intestinal Tract and Pancreas Diseases 

8/2 Trubetskaya ul., Moscow, 119991

Россия

O. B. Shchukina

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: burmao@gmail.com

Oksana B. Shchukina – MD, PhD, Head of Center of Inflammatory Bowel Disease 

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Россия

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Copyright (c) 2021 Belousova E.A., Kozlov I.G., Abdulganieva D.I., Alexeeva O.P., Gubonina I.V., Lishchinskaya A.A., Tarasova L.V., Chashkova E.Y., Shapina M.V., Shifrin O.S., Shchukina O.B.

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