Email this article DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE PEMPHIGUS
- Authors: Makhneva N.V.1,2,3, Davidenko E.B.1,4, Beletskaya L.V.5,6
-
Affiliations:
- Moscow Research and Practical Center of Dermatovenereology and Cosmetology
- 17 Leninskiy prospekt, Moscow, 119071, Russian Federation Moscow Regional Research and Clinical Institute (MONIKI)
- 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
- 17 Leninskiy prospekt, Moscow, 119071, Russian Federation
- Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
- 1 Shchukinskaya ul., Moscow, 123182, Russian Federation
- Issue: No 34 (2014)
- Pages: 9-14
- Section: DERMATOLOGY
- URL: https://almclinmed.ru/jour/article/view/158
- DOI: https://doi.org/10.18786/2072-0505-2014-34-9-14
- ID: 158
Cite item
Full Text
Abstract
Autoimmune pemphigus is a severe, potentially fatal disease affecting skin and mucous membranes. It is characterized by the presence of IgGautoantibodies against target desmosomal antigens of stratified squamous epithelium. Despite the promising results of the molecular biological research in the area of the pathogenesis of autoimmune pemphigus during past decades, diagnosis/ differential diagnosis of pemphigus remains one of the most important problems of dermatology due to rapid progression and expansion of the skin and mucous membranes lesions and the high risk of disability and death in inadequately treated patients. Correct and timely diagnosis of autoimmune pemphigus contributes to proper treatment and reduces complications risk.
Keywords
About the authors
N. V. Makhneva
Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17 Leninskiy prospekt, Moscow, 119071, Russian FederationMoscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Author for correspondence.
Email: makhneva@mail.ru
MD, PhD, Professor, Deputy Director for Research1 ; Professor, Dermatovenereology and Dermato-Oncology Department, Postgraduate Medical School2 Россия
E. B. Davidenko
Moscow Research and Practical Center of Dermatovenereology and Cosmetology; 17 Leninskiy prospekt, Moscow, 119071, Russian Federation
Email: fake@neicon.ru
PhD, Research Fellow, Fundamental Methods Research Laboratory Россия
L. V. Beletskaya
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs; 1 Shchukinskaya ul., Moscow, 123182, Russian Federation
Email: fake@neicon.ru
MD, PhD, Professor, Chief Research Fellow, Immunohistochemistry Laboratory, Clinical Pathology Department Россия
References
- Белецкая ЛВ, Махнева НВ. Меченые антитела в нормальной и патологической морфологии (атлас). М.: МНПИ; 2000. 110 c. (Beletskaya LV, Makhneva NV. Labelled antibodies in normal and pathological morphology. Moscow: MNPI; 2000. 110 p. Russian).
- Ben Lagha N, Poulesquen V, Roujeau JC, Alantar A, Maman L. Pemphigus vulgaris: a case-based update. J Can Dent Assoc. 2005;71(9):667–72.
- Теплюк НП, Кузьмина ТС, Куприянова АГ, Дулькин ИС, Давыдовская НИ. Случай стероидрезистентной пузырчатки с летальным исходом. Российский журнал кожных и венерических болезней. 2006;(4):58–9. (Teplyuk NP, Kuz’mina TS, Kupriyanova AG, Dul’kin IS, Davydovskaya NI. [Fatal steroid-resistant pemphigus: a clinical case]. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2006;(4):58–9. Russian).
- Firooz A, Ghandi N, Hallaji Z, Chams-Davatchi C, Valikhani M, Karbakhsh Davari M. Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris. Arch Dermatol. 2008;144(9):1143–7.
- Murrell DF, Dick S, Ahmed AR, Amagai M, Barnadas MA, Borradori L, Bystryn JC, Cianchini G, Diaz L, Fivenson D, Hall R, Harman KE, Hashimoto T, Hertl M, Hunzelmann N, Iranzo P, Joly P, Jonkman MF, Kitajima Y, Korman NJ, Martin LK, Mimouni D, Pandya AG, Payne AS, Rubenstein D, Shimizu H, Sinha AA, Sirois D, Zillikens D, Werth VP. Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. J Am Acad Dermatol. 2008;58(6):1043–6.
- Махнева НВ, Белецкая ЛВ. Иммунопатологические аспекты аутоиммунных буллезных дерматозов. Клиника, диагностика, этиология, патогенез и молекулярно-биологические особенности. Palmarium Academic Publishing; 2012. 411 с. (Makhneva NV, Beletskaya LV. Immunopathological aspects of autoimmune bullous dermatoses. Clinical features, diagnosis, etiology, pathogenesis, molecular and biological characteristics. Palmarium Academic Publishing; 2012. 411 р. Russian).
Supplementary files
