Email this article Cardiac visceral fat volume estimation from low-dose chest computed tomography: a study with a designed beating heart phantom
- Authors: Chernina V.Y.1, Kulberg N.S.1, Aleshina O.O.1, Korb T.A.1, Blokhin I.A.1, Morozov S.P.1, Gombolevskiy V.A.1
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Affiliations:
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
- Issue: Vol 49, No 1 (2021)
- Pages: 61-71
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/1423
- DOI: https://doi.org/10.18786/2072-0505-2021-49-006
- ID: 1423
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Abstract
Background: Since 2017, a pilot project for lung cancer screening by chest low dose computed tomography (LDCT) has been implemented in Moscow. Patients to be included into the screening have risk factors for ischemic heart disease (IHD). The association between epicardial adipose tissue (EAT) volume and coronary artery atherosclerosis, IHD, and atrial fibrillation has been demonstrated previously.
Aim: To demonstrate the feasibility of LDCTbased EAT volumetry using a dynamic (contracting) heart phantom.
Materials and methods: The study was performed with the designed dynamic heart phantom and chest phantom in two stages. At stage I, two adipose tissue pieces were scanned inside and outside the chest phantom using CT and LDCT. At stage II, the dynamic heart phantom was scanned outside and inside the chest phantom. In addition, we scanned the heart phantom with a coronary calcium phantom. The contracting heart phantom was developed within three months. All scans of the phantom were performed within one day. We determined the adipose tissue thresholds in LDCT and the EAT volumetric error with both chest CT and LDCT. Measurements of the adipose tissue volumes were performed by the radiologist twice with semi-automatic software.
Results: The results of stage I helped to identify optimal density thresholds for LDCT-based adipose tissue volumetry in lung cancer screening, ranging from -250 HU to -30 HU. The stage II results showed that for all heart phantom scanning variants, the average EAT volumetry error did not exceed 5%, except for the case of contracting heart phantom with added coronary calcium in a chest phantom with body mass index (BMI) 29 (-5.92%). Adding the coronary calcium phantom to the heart phantom in LDCT increased the error by an average of 4% in BMI 23 and BMI 29 chest phantoms.
Conclusion: LDCT-based EAT volumetry with fat density threshold from -250 HU to -30 HU is feasible in lung cancer screening, including patients with coronary calcium. However, considering the phantom design, further patient studies, and correlation of EAT volumes between LDCT for lung cancer screening and сoronary CT angiography are required.
About the authors
V. Yu. Chernina
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Author for correspondence.
Email: chernina909@gmail.com
ORCID iD: 0000-0002-0302-293X
Valeria Yu. Chernina – MD, Head of Radiology Research Sector
24–1 Petrovka ul., Moscow, 127051
РоссияN. S. Kulberg
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: kulberg@npcmr.ru
ORCID iD: 0000-0001-7046-7157
Nikolay S. Kulberg – PhD (in Phys. and Math.), Head of Medical Imaging Department
24–1 Petrovka ul., Moscow, 127051
РоссияO. O. Aleshina
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: olya.aleshina.tula@gmail.com
ORCID iD: 0000-0001-9924-0204
Olga O. Aleshina – MD, Junior Research Fellow, Radiology Research Sector
24–1 Petrovka ul., Moscow, 127051
РоссияT. A. Korb
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: t-anya@list.ru
ORCID iD: 0000-0001-9291-1466
Tatiana A. Korb – Junior Research Fellow, Radiology Research Sector
24–1 Petrovka ul., Moscow, 127051
РоссияI. A. Blokhin
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: i.blokhin@npcmr.ru
ORCID iD: 0000-0002-2681-9378
Ivan A. Blokhin – MD, Junior Research Fellow, Radiology Research Sector
24–1 Petrovka ul., Moscow, 127051
РоссияS. P. Morozov
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: morozov@npcmr.ru
ORCID iD: 0000-0001-6545-6170
Sergey P. Morozov – MD, PhD, Professor, Director
24–1 Petrovka ul., Moscow, 127051
РоссияV. A. Gombolevskiy
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department
Email: g_victor@mail.ru
ORCID iD: 0000-0003-1816-1315
Victor A. Gombolevskiy – MD, PhD, Head of Medical Research Department
24–1 Petrovka ul., Moscow, 127051
РоссияReferences
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