Что мы знаем и чего не знаем о заболеваниях почек у женщин; вопросы без ответов и ответы на незаданные вопросы: размышления по поводу Всемирного дня почки и Международного женского дня

Обложка
  • Авторы: Пикколи Д.Б.1,2, Альрухами М.3, Лиу Ж.4, Захарова Е.В.5,6,7, Левин А.8
  • Учреждения:
    1. Туринский университет
    2. Госпитальный центр Ле-Ман
    3. Дубайский медицинский колледж
    4. Медицинская школа Нанкинского университета
    5. ГБУЗ Москвы «Городская клиническая больница им. С.П. Боткина» ДЗМ
    6. ФГБОУ ВО «Московский государственный медико-стоматологический университет» Минздрава России
    7. ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
    8. Университет Британской Колумбии
  • Выпуск: Том 46, № 1 (2018)
  • Страницы: 2-15
  • Раздел: ОБЗОР
  • URL: https://almclinmed.ru/jour/article/view/751
  • DOI: https://doi.org/10.18786/2072-0505-2018-46-1-2-15
  • ID: 751


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Аннотация

Около 10% взрослого населения планеты страдает хронической болезнью почек, которая входит в список 20 основных причин смерти во всем мире и ведет к пагубным последствиям как для самих пациентов, так и для членов их семей. Всемирный день почки в 2018 совпадает с Международным женским днем, что дает повод задуматься об особой важности состояния здоровья женщин и в особенности о «почечном здоровье» для ныне живущей популяции и будущих поколений. Нам представляется уникальная возможность не только как можно больше узнать об особенностях заболеваний почек у женщин, но и шире использовать полученные знания. Женщины, девушки и девочки в целом составляют примерно 50% населения мира. Очевиден их огромный вклад в  жизнь общества, не говоря уже о  важнейшей роли в семейной жизни. Вместе с тем гендерные различия в доступе к образованию, медицинской помощи и участию в клинических исследованиях все еще существуют практически повсеместно. Беременность, создающая особую нагрузку на организм женщины и нередко оказывающаяся поводом для выявления уже существующих заболеваний почек, может также приводить к манифестации острых и хронических почечных заболеваний, которые, в свою очередь, могут сказываться на потомстве, в том числе и на состоянии почек. Многие аутоиммунные и другие заболевания чаще развиваются у женщин,  чем у мужчин, и неблагоприятно сказываются на способности к  деторождению и  на состоянии плода. Осложнения диализа у  женщин отличаются от осложнений у мужчин, и кроме того, женщины с большей вероятностью оказываются донорами, нежели чем реципиентами почечного трансплантата. В этой обзорной статье мы сконцентрировали внимание на том, что мы знаем и чего мы не знаем о «почечном здоровье» и заболеваниях почек у женщин, и на том, что мы можем и должны узнать в будущем для улучшения исходов заболеваний почек во всем мире.

Авторы выступают от имени Организационного комитета Всемирного дня почки.

Члены Организационного комитета Всемирного дня почки: Кам Тао Ли Ф., Гарсиа-Гарсиа Г., Венджамен-Гариби М., Калантар-Заде К., Кернан Ч., Кумарасвами Л., Пикколи Д.Б., Саади Г., Фокс Л., Захарова Е.В., Андреоли Ш.

Об авторах

Д. Б. Пикколи

Туринский университет; Госпитальный центр Ле-Ман

Email: fake@neicon.ru

Пикколи Джиорджина Барбара – профессор, отдел клинических и биологических наук ТурУ; врач-невролог, отделение неврологии ГЦ Ле-Ман.

101248, Турин, Виа Верди, 8; 72037, Ле-Ман, Авеню Рубиллар, 194

Италия

М. Альрухами

Дубайский медицинский колледж

Email: fake@neicon.ru

Альрухами Мона – профессор, отдел медицины.

20170, Дубай, Аль Мухайсанах, Аль Мижар, 1

ОАЭ

Ж.-Х. Лиу

Медицинская школа Нанкинского университета

Email: fake@neicon.ru

Лиу Жи-Хонг – кандидат медицинских наук, профессор, директор Национального центра клинических исследований заболеваний почек, госпиталь Джинлинг.

210093, провинция Жиангсу, Нанкин, район Гулоу, Ханку Роад, 22

КНР

Е. В. Захарова

ГБУЗ Москвы «Городская клиническая больница им. С.П. Боткина» ДЗМ; ФГБОУ ВО «Московский государственный медико-стоматологический университет» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

Email: fake@neicon.ru

Захарова Елена Викторовна – кандидат медицинских наук, доцент, заведующая отделением нефрологии ГКБ им. С.П. Боткина; доцент кафедры нефрологии МГМСУ, РМАНПО.

125284, Москва, 2-й Боткинский проезд, 5; 127473, Москва, ул. Делегатская, 20/1; 123242, Москва, ул. Баррикадная, 2

Россия

А. Левин

Университет Британской Колумбии

Автор, ответственный за переписку.
Email: alevin@providencehealth.bc.ca

Левин Адера – профессор, член Королевского колледжа терапевтов и хирургов Канады, руководитель отделения нефрологии, отдел медицины.

V6T 1Z4, Ванкувер, 2329 Вест Молл Ванкувер, Британская Колумбия

Канада

Список литературы

  1. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990– 2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053): 1545–602. doi: 10.1016/S0140-6736(16)31678-6.
  2. von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton Pipkin F, Côté AM, Douglas MJ, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA; PIERS Study Group. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet. 2011;377(9761): 219–27. doi: 10.1016/S01406736(10)61351-7.
  3. Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM, Hofmeyr GJ. Pre-eclampsia. Lancet. 2016;387(10022): 999–1011. doi: 10.1016/S0140-6736(15)00070-7.
  4. Vikse BE, Irgens LM, Leivestad T, Skjaerven R, Iversen BM. Preeclampsia and the risk of endstage renal disease. N Engl J Med. 2008;359(8): 800–9. doi: 10.1056/NEJMoa0706790.
  5. Theilen LH, Fraser A, Hollingshaus MS, Schliep KC, Varner MW, Smith KR, Esplin MS. All-cause and cause-specific mortality after hypertensive disease of pregnancy. Obstet Gynecol. 2016;128(2): 238–44. doi: 10.1097/AOG.0000000000001534.
  6. Piccoli GB, Cabiddu G, Attini R, Vigotti FN, Maxia S, Lepori N, Tuveri M, Massidda M, Marchi C, Mura S, Coscia A, Biolcati M, Gaglioti P, Nichelatti M, Pibiri L, Chessa G, Pani A, Todros T. Risk of adverse pregnancy outcomes in women with CKD. J Am Soc Nephrol. 2015;26(8): 2011– 22. doi: 10.1681/ASN.2014050459.
  7. Zhang JJ, Ma XX, Hao L, Liu LJ, Lv JC, Zhang H. A systematic review and meta-analysis of outcomes of pregnancy in CKD and CKD outcomes in pregnancy. Clin J Am Soc Nephrol. 2015;10(11): 1964–78. doi: 10.2215/CJN.09250914.
  8. Alkhunaizi A, Melamed N, Hladunewich MA. Pregnancy in advanced chronic kidney disease and end-stage renal disease. Curr Opin Nephrol Hypertens. 2015;24(3): 252–9. doi: 10.1097/MNH.0000000000000119.
  9. Piccoli GB, Cabiddu G, Castellino S, Gernone G, Santoro D, Moroni G, Spotti D, Giacchino F, Attini R, Limardo M, Maxia S, Fois A, Gammaro L, Todros T; Kidney and Pregnancy Study Group of Italian Society of Nephrology. A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy. J Nephrol. 2017;30(3): 307–17. doi: 10.1007/s40620-017-0390-1.
  10. Liu Y, Ma X, Zheng J, Liu X, Yan T. Pregnancy outcomes in patients with acute kidney injury during pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2017;17(1): 235. doi: 10.1186/s12884-0171402-9.
  11. Jim B, Garovic VD. Acute Kidney Injury in Pregnancy. Semin Nephrol. 2017;37(4): 378–85. doi: 10.1016/j.semnephrol.2017.05.010.
  12. Acharya A. Management of acute kidney injury in pregnancy for the obstetrician. Obstet Gynecol Clin North Am. 2016;43(4): 747–65. doi: 10.1016/j.ogc.2016.07.007.
  13. Iseki K. Gender differences in chronic kidney disease. Kidney Int. 2008;74(4): 415–7. doi: 10.1038/ki.2008.261.
  14. Nitsch D, Grams M, Sang Y, Black C, Cirillo M, Djurdjev O, Iseki K, Jassal SK, Kimm H, Kronenberg F, Oien CM, Levey AS, Levin A, Wood ward M, Hemmelgarn BR; Chronic Kidney Disease Prognosis Consortium. Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ. 2013;346:f324. doi: 10.1136/bmj.f324.
  15. Levin A, Djurdjev O, Beaulieu M, Er L. Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort. Am J Kidney Dis. 2008;52(4): 661–71. doi: 10.1053/j.ajkd.2008.06.023.
  16. Weiner DE, Tighiouart H, Elsayed EF, Griffith JL, Salem DN, Levey AS, Sarnak MJ. The Framingham predictive instrument in chronic kidney disease. J Am Coll Cardiol. 2007;50(3): 217–24. doi: 10.1016/j.jacc.2007.03.037.
  17. Oladapo OT, Adetoro OO, Ekele BA, Chama C, Etuk SJ, Aboyeji AP, Onah HE, Abasiattai AM, Adamu AN, Adegbola O, Adeniran AS, Aimakhu CO, Akinsanya O, Aliyu LD, Ande AB, Ashimi A, Bwala M, Fabamwo A, Geidam AD, Ikechebelu JI, Imaralu JO, Kuti O, Nwachukwu D, Omo-Aghoja L, Tunau K, Tukur J, Umeora O, Umezulike AC, Dada OA, Tunçalp Ö, Vogel JP, Gülmezoglu AM; Nigeria Near-miss and Maternal Death Surveillance Network. When getting there is not enough: a nationwide cross-sectional study of 998 maternal deaths and 1451 near-misses in public tertiary hospitals in a low-income country. BJOG. 2016;123(6): 928–38. doi: 10.1111/14710528.13450.
  18. Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, Zeeman GG, Brown MA. The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Pregnancy Hypertens. 2014;4(2): 97–104. doi: 10.1016/j.preghy.2014.02.001.
  19. Liu YM, Bao HD, Jiang ZZ, Huang YJ, Wang NS. Pregnancy-related acute kidney injury and a review of the literature in China. Intern Med. 2015;54(14): 1695–703. doi: 10.2169/internalmedicine.54.3870.
  20. Prakash J, Pant P, Prakash S, Sivasankar M, Vohra R, Doley PK, Pandey LK, Singh U. Changing picture of acute kidney injury in pregnancy: Study of 259 cases over a period of 33 years. Indian J Nephrol. 2016;26(4): 262–7. doi: 10.4103/0971-4065.161018.
  21. Ibarra-Hernández M, Orozco-Guillén OA, de la Alcantar-Vallín ML, Garrido-Roldan R, Jiménez-Alvarado MP, Castro KB, Villa-Villagrana F, Borbolla M, Gallardo-Gaona JM, GarcíaGarcía G, Reyes-Paredes N, Piccoli GB. Acute kidney injury in pregnancy and the role of underlying CKD: a point of view from México. J Nephrol. 2017;30(6): 773–80. doi: 10.1007/s40620-017-0444-4.
  22. Blázquez A, García D, Rodríguez A, Vassena R, Figueras F, Vernaeve V. Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis. J Assist Reprod Genet. 2016;33(7): 855–63. doi: 10.1007/s10815-0160701-9.
  23. O'Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, de Alvarado M, Carbone IF, Dutemeyer V, Fiolna M, Frick A, Karagiotis N, Mastrodima S, de Paco Matallana C, Papaioannou G, Pazos A, Plasencia W, Nicolaides KH. Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol. 2017;49(6): 756–60. doi: 10.1002/uog.17455.
  24. Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S. Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374(1): 13–22. doi: 10.1056/NEJMoa1414838.
  25. Garovic VD. The role of the podocyte in preeclampsia. Clin J Am Soc Nephrol. 2014;9(8): 1337–40. doi: 10.2215/CJN.05940614.
  26. Wide-Swensson D, Strevens H, Willner J. Antepartum percutaneous renal biopsy. Int J Gynaecol Obstet. 2007;98(2): 88–92. doi: 10.1016/j.ijgo.2007.03.049.
  27. Shiiki H, Dohi K, Hanatani M, Fujii Y, Sanai H, Ichijo M, Shimamoto I, Ishikawa H, Watanabe T. Focal and segmental glomerulosclerosis in preeclamptic patients with nephrotic syndrome. Am J Nephrol. 1990;10(3): 205–12. doi: 10.1159/000168082.
  28. Linsell L, Malouf R, Morris J, Kurinczuk JJ, Marlow N. Risk factor models for neurodevelopmental outcomes in children born very preterm or with very low birth weight: a systematic review of methodology and reporting. Am J Epidemiol. 2017;185(7): 601–12. doi: 10.1093/aje/kww135.
  29. Guellec I, Lapillonne A, Marret S, Picaud JC, Mitanchez D, Charkaluk ML, Fresson J, Arnaud C, Flamand C, Cambonie G, Kaminski M, Roze JC, Ancel PY; Étude Épidémiologique sur les Petits Âges Gestationnels (EPIPAGE; [Epidemiological Study on Small Gestational Ages]) Study Group. Effect of intra- and extrauterine growth on long-term neurologic outcomes of very preterm infants. J Pediatr. 2016;175:93–9.e1. doi: 10.1016/j.jpeds.2016.05.027.
  30. Moore T, Hennessy EM, Myles J, Johnson SJ, Draper ES, Costeloe KL, Marlow N. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ. 2012;345:e7961. doi: 10.1136/bmj.e7961.
  31. Guillén U, DeMauro S, Ma L, Zupancic J, Roberts R, Schmidt B, Kirpalani H. Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review. Arch Pediatr Adolesc Med. 2012;166(2): 178–84. doi: 10.1001/archpediatrics.2011.616.
  32. Ranke MB, Schweizer R, Rodemann SM, Bevot A, Martin DD, Goelz R, Wollmann HA, Krägeloh-Mann I, Binder G. Schoolchildren born VLBW or VLGA show height-related changes in body composition and muscle function but no evidence of metabolic syndrome risk factors. Results from the NEOLONG study. J Pediatr Endocrinol Metab. 2016;29(2): 163–72. doi: 10.1515/jpem-2015-0266.
  33. Castanys-Muñoz E, Kennedy K, Castañeda-Gutiérrez E, Forsyth S, Godfrey KM, Koletzko B, Ozanne SE, Rueda R, Schoemaker M, van der Beek EM, van Buuren S, Ong KK. Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatr. 2017;106(8): 1230–8. doi: 10.1111/apa.13868.
  34. Ong KK, Kennedy K, Castañeda-Gutiérrez E, Forsyth S, Godfrey KM, Koletzko B, Latulippe ME, Ozanne SE, Rueda R, Schoemaker MH, van der Beek EM, van Buuren S, Fewtrell M. Postnatal growth in preterm infants and later health outcomes: a systematic review. Acta Paediatr. 2015;104(10): 974–86. doi: 10.1111/apa.13128.
  35. Low Birth Weight and Nephron Number Working Group. The Impact of Kidney Development on the Life Course: A Consensus Document for Action. Nephron. 2017;136(1): 3–49. doi: 10.1159/000457967.
  36. Luyckx VA, Bertram JF, Brenner BM, Fall C, Hoy WE, Ozanne SE, Vikse BE. Effect of fetal and child health on kidney development and longterm risk of hypertension and kidney disease. Lancet. 2013;382(9888): 273–83. doi: 10.1016/ S0140-6736(13)60311-6.
  37. Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes – a global concern. Nat Rev Nephrol. 2015 Mar;11(3): 135–49. doi: 10.1038/nrneph.2014.251.
  38. Davison JM, Lindheimer MD. Pregnancy and chronic kidney disease. Semin Nephrol. 2011;31(1): 86–99. doi: 10.1016/j.semnephrol.2010.10.008.
  39. Hall M. Pregnancy in women with CKD: a success story. Am J Kidney Dis. 2016;68(4): 633–9. doi: 10.1053/j.ajkd.2016.04.022.
  40. Nevis IF, Reitsma A, Dominic A, McDonald S, Thabane L, Akl EA, Hladunewich M, Akbari A, Joseph G, Sia W, Iansavichus AV, Garg AX. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol. 2011;6(11): 2587–98. doi: 10.2215/CJN.10841210.
  41. Cabiddu G, Castellino S, Gernone G, Santoro D, Moroni G, Giannattasio M, Gregorini G, Giacchino F, Attini R, Loi V, Limardo M, Gammaro L, Todros T, Piccoli GB. A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy. J Nephrol. 2016;29(3): 277–303. doi: 10.1007/s40620-016-0285-6.
  42. Garg AX, Nevis IF, McArthur E, Sontrop JM, Koval JJ, Lam NN, Hildebrand AM, Reese PP, Storsley L, Gill JS, Segev DL, Habbous S, Bugeja A, Knoll GA, Dipchand C, Monroy-Cuadros M, Lentine KL; DONOR Network. Gestational hypertension and preeclampsia in living kidney donors. N Engl J Med. 2015;372(2): 124–33. doi: 10.1056/NEJMoa1408932.
  43. Josephson MA. Transplantation: pregnancy after kidney donation: more questions than answers. Nat Rev Nephrol. 2009;5(9): 495–7. doi: 10.1038/nrneph.2009.129.
  44. Gianfreda D, Quaglini S, Frontini G, Raffiotta F, Messa P, Moroni G. Does pregnancy have any impact on long term damage accrual and on the outcome of lupus nephritis? J Autoimmun. 2017;84:46–54. doi: 10.1016/j.jaut.2017.06.003.
  45. Blom K, Odutayo A, Bramham K, Hladunewich MA. Pregnancy and Glomerular Disease: A Systematic Review of the Literature with Management Guidelines. Clin J Am Soc Nephrol. 2017;12(11): 1862–72. doi: 10.2215/CJN.00130117.
  46. Imbasciati E, Gregorini G, Cabiddu G, Gammaro L, Ambroso G, Del Giudice A, Ravani P. Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis. 2007;49(6): 753– 62. doi: 10.1053/j.ajkd.2007.03.022.
  47. Fischer MJ. Chronic kidney disease and pregnancy: maternal and fetal outcomes. Adv Chronic Kidney Dis. 2007;14(2): 132–45. doi: 10.1053/j.ackd.2007.01.004.
  48. Bramham K. Diabetic nephropathy and pregnancy. Semin Nephrol. 2017;37(4): 362–9. doi: 10.1016/j.semnephrol.2017.05.008.
  49. Eswarappa M, Rakesh M, Sonika P, Snigdha K, Midhun M, Kaushik K, Chennabasappa GK, Sujeeth B. Spectrum of renal injury in pregnancy-induced hypertension: Experience froma single center in India. Saudi J Kidney Dis Transpl. 2017;28(2): 279–84. doi: 10.4103/13192442.202790.
  50. Prakash J. The kidney in pregnancy: a journey of three decades. Indian J Nephrol. 2012;22(3): 159–67. doi: 10.4103/0971-4065.98750.
  51. Piccoli GB, Fassio F, Attini R, Parisi S, Biolcati M, Ferraresi M, Pagano A, Daidola G, Deagostini MC, Gaglioti P, Todros T. Pregnancy in CKD: whom should we follow and why? Nephrol Dial Transplant. 2012;27 Suppl 3:iii111–8. doi: 10.1093/ndt/gfs302.
  52. Piccoli GB, Cabiddu G, Daidone G, Guzzo G, Maxia S, Ciniglio I, Postorino V, Loi V, Ghiotto S, Nichelatti M, Attini R, Coscia A, Postorino M, Pani A; Italian Study Group “Kidney and Pregnancy”. The children of dialysis: live-born babies from on-dialysis mothers in Italy – an epidemiological perspective comparing dialysis, kidney transplantation and the overall population. Nephrol Dial Transplant. 2014;29(8): 1578–86. doi: 10.1093/ndt/gfu092.
  53. Jesudason S, Grace BS, McDonald SP. Pregnancy outcomes according to dialysis commencing before or after conception in women with ESRD. Clin J Am Soc Nephrol. 2014;9(1): 143–9. doi: 10.2215/CJN.03560413.
  54. Hladunewich MA, Hou S, Odutayo A, Cornelis T, Pierratos A, Goldstein M, Tennankore K, Keunen J, Hui D, Chan CT. Intensive hemodialysis associates with improved pregnancy outcomes: a Canadian and United States cohort comparison. J Am Soc Nephrol. 2014;25(5): 1103–9. doi: 10.1681/ASN.2013080825.
  55. Piccoli GB, Minelli F, Versino E, Cabiddu G, Attini R, Vigotti FN, Rolfo A, Giuffrida D, Colombi N, Pani A, Todros T. Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant. 2016;31(11): 1915–34. doi: 10.1093/ndt/gfv395.
  56. Deshpande NA, James NT, Kucirka LM, Boyarsky BJ, Garonzik-Wang JM, Montgomery RA, Segev DL. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant. 2011;11(11): 2388–404. doi: 10.1111/j.16006143.2011.03656.x.
  57. Deshpande NA, Coscia LA, Gomez-Lobo V, Moritz MJ, Armenti VT. Pregnancy after solid organ transplantation: a guide for obstetric management. Rev Obstet Gynecol. 2013;6(3–4): 116–25.
  58. Bramham K, Nelson-Piercy C, Gao H, Pierce M, Bush N, Spark P, Brocklehurst P, Kurinczuk JJ, Knight M. Pregnancy in renal transplant recipients: a UK national cohort study. Clin J Am Soc Nephrol. 2013;8(2): 290–8. doi: 10.2215/CJN.06170612.
  59. Piccoli GB, Cabiddu G, Attini R, Gerbino M, Todeschini P, Perrino ML, Manzione AM, Piredda GB, Gnappi E, Caputo F, Montagnino G, Bellizzi V, Di Loreto P, Martino F, Montanaro D, Rossini M, Castellino S, Biolcati M, Fassio F, Loi V, Parisi S, Versino E, Pani A, Todros T; Italian Study group on Kidney and Pregnancy of the Italian Society of Nephrology. Working Group on Pregnancy in Renal Transplantation. Outcomes of pregnancies after kidney transplantation: lessons learned from CKD. A comparison of transplanted, nontransplanted chronic kidney disease patients and low-risk pregnancies: a multicenter nationwide analysis. Transplantation. 2017;101(10): 2536–44. doi: 10.1097/TP.0000000000001645.
  60. Webster P, Lightstone L, McKay DB, Josephson MA. Pregnancy in chronic kidney disease and kidney transplantation. Kidney Int. 2017;91(5): 1047–56. doi: 10.1016/j.kint.2016.10.045.
  61. Pietrzak B, Mazanowska N, Kociszewska-Najman B, Szymusik I, Grzechocińska B, Pazik J, Jabiry-Zieniewicz Z, Popow A, Wielgos M. Successful pregnancy outcome after in vitro fertilization in a kidney graft recipient: a case report and literature review. Ann Transplant. 2015;20:338–41. doi: 10.12659/AOT.893735.
  62. Norrman E, Bergh C, Wennerholm UB. Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Hum Reprod. 2015;30(1): 205–13. doi: 10.1093/humrep/deu293.
  63. Tedeschi SK, Bermas B, Costenbader KH. Sexual disparities in the incidence and course of SLE and RA. Clin Immunol. 2013;149(2): 211–8. doi: 10.1016/j.clim.2013.03.003.
  64. Marder W, Vinet É, Somers EC. Rheumatic autoimmune diseases in women and midlife health. Womens Midlife Health. 2015;1. pii: 11. doi: 10.1186/s40695-015-0012-9.
  65. Ortona E, Pierdominici M, Maselli A, Veroni C, Aloisi F, Shoenfeld Y. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita. 2016;52(2): 205–12. doi: 10.4415/ANN_16_02_12.
  66. Petri M. Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2002;16(5): 847–58. doi: https://doi.org/10.1053/berh.2002.0259.
  67. Weckerle CE, Niewold TB. The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies. Clin Rev Allergy Immunol. 2011;40(1): 42–9. doi: 10.1007/s12016-009-8192-4.
  68. Scofield RH, Bruner GR, Namjou B, Kimberly RP, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Reid J, Harris B, Li S, Kelly JA, Harley JB. Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum. 2008;58(8): 2511–7. doi: 10.1002/art.23701.
  69. Pierdominici M, Ortona E. Estrogen impact on autoimmunity onset and progression: the paradigm of systemic lupus erythematosus. International Trends in Immunity. 2013;1(2): 24–34.
  70. Maselli A, Conti F, Alessandri C, Colasanti T, Barbati C, Vomero M, Ciarlo L, Patrizio M, Spinelli FR, Ortona E, Valesini G, Pierdominici M. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus. Biol Sex Differ. 2016;7:3. doi: 10.1186/s13293-016-0057-y.
  71. Kim SJ, Schätzle S, Ahmed SS, Haap W, Jang SH, Gregersen PK, Georgiou G, Diamond B. Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus. Nat Immunol. 2017;18(9): 1016–24. doi: 10.1038/ni.3793.
  72. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017;8:16021. doi: 10.1038/ncomms16021.
  73. Niewold TB, Hua J, Lehman TJ, Harley JB, Crow MK. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun. 2007;8(6): 492– 502. doi: 10.1038/sj.gene.6364408.
  74. Tower C, Mathen S, Crocker I, Bruce IN. Regulatory T cells in systemic lupus erythematosus and pregnancy. Am J Reprod Immunol. 2013;69(6): 588–95. doi: 10.1111/aji.12081.
  75. Almaani S, Meara A, Rovin BH. Update on lupus nephritis. Clin J Am Soc Nephrol. 2017;12(5): 825–35. doi: 10.2215/CJN.05780616.
  76. Buyon JP, Kim MY, Guerra MM, Lu S, Reeves E, Petri M, Laskin CA, Lockshin MD, Sammaritano LR, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Salmon JE. Kidney outcomes and risk factors for nephritis (flare/de novo) in a multiethnic cohort of pregnant patients with lupus. Clin J Am Soc Nephrol. 2017;12(6): 940–6. doi: 10.2215/CJN.11431116.
  77. Yelin E, Yazdany J, Trupin L. Relationship between process of care and a subsequent increase in damage in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2017;69(6): 927–32. doi: 10.1002/acr.22977.
  78. Kaplowitz ET, Ferguson S, Guerra M, Laskin CA, Buyon JP, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Merrill JT, Katz P, Salmon JE. Contribution of socioeconomic status to racial/ethnic disparities in adverse pregnancy outcomes among women with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2018;70(2): 230–5. doi: 10.1002/acr.23263.
  79. Myasoedova E, Crowson CS, Kremers HM, Therneau TM, Gabriel SE. Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955–2007. Arthritis Rheum. 2010;62(6): 1576–82. doi: 10.1002/art.27425.
  80. Goemaere S, Ackerman C, Goethals K, De Keyser F, Van der Straeten C, Verbruggen G, Mielants H, Veys EM. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol. 1990;17(12): 1620–2.
  81. de Man YA, Dolhain RJ, van de Geijn FE, Willemsen SP, Hazes JM. Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum. 2008;59(9): 1241–8. doi: 10.1002/art.24003.
  82. Icardi A, Araghi P, Ciabattoni M, Romano U, Lazzarini P, Bianchi G. Kidney involvement in rheumatoid arthritis. Reumatismo. 2003;55(2): 76–85. doi: https://doi.org/10.4081/reumatismo.2003.76.
  83. Anders HJ, Vielhauer V. Renal co-morbidity in patients with rheumatic diseases. Arthritis Res Ther. 2011;13(3): 222. doi: 10.1186/ar3256.
  84. Chiu HY, Huang HL, Li CH, Chen HA, Yeh CL, Chiu SH, Lin WC, Cheng YP, Tsai TF, Ho SY. Increased risk of chronic kidney disease in rheumatoid arthritis associated with cardiovascular complications – a national population-based cohort study. PLoS One. 2015;10(9):e0136508. doi: 10.1371/journal.pone.0136508.
  85. Vinet É, Bernatsky S, Hudson M, Pineau CA, Baron M; Canadian Scleroderma Research Group. Effect of menopause on the modified Rodnan skin score in systemic sclerosis. Arthritis Res Ther. 2014;16(3):R130. doi: 10.1186/ar4587.
  86. Sammaritano LR. Menopause in patients with autoimmune diseases. Autoimmun Rev. 2012;11(6–7):A430–6. doi: 10.1016/j.autrev.2011.11.006.
  87. Penn H, Denton CP. Diagnosis, management and prevention of scleroderma renal disease. Curr Opin Rheumatol. 2008;20(6): 692–6. doi: 10.1097/BOR.0b013e3283108df7.
  88. Anders HJ, Wiebecke B, Haedecke C, Sanden S, Combe C, Schlöndorff D. MPO-ANCA-Positive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease? Am J Kidney Dis. 1999;33(4):e3. doi: https://doi.org/10.1016/S0272-6386(99)70244-1.
  89. Zakharova EV, Makarova TA, Stolyarevich ES (2016) ANCA-associated vasculitis in patient with crest-syndrome – case report. Arch Clin Nephrol;2(1): 049–052. doi: http://dx.doi.org/10.17352/acn.000015.
  90. Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS, Levin A. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013;382(9887): 158–69. doi: 10.1016/S0140-6736(13)60439-0.
  91. Saran R, Robinson B, Abbott KC, Agodoa LY, Albertus P, Ayanian J, Balkrishnan R, Bragg-Gresham J, Cao J, Chen JL, Cope E, Dharmarajan S, Dietrich X, Eckard A, Eggers PW, Gaber C, Gillen D, Gipson D, Gu H, Hailpern SM, Hall YN, Han Y, He K, Hebert H, Helmuth M, Herman W, Heung M, Hutton D, Jacobsen SJ, Ji N, Jin Y, Kalantar-Zadeh K, Kapke A, Katz R, Kovesdy CP, Kurtz V, Lavalee D, Li Y, Lu Y, McCullough K, Molnar MZ, Montez-Rath M, Morgenstern H, Mu Q, Mukhopadhyay P, Nallamothu B, Nguyen DV, Norris KC, O'Hare AM, Obi Y, Pearson J, Pisoni R, Plattner B, Port FK, Potukuchi P, Rao P, Ratkowiak K, Ravel V, Ray D, Rhee CM, Schaubel DE, Selewski DT, Shaw S, Shi J, Shieu M, Sim JJ, Song P, Soohoo M, Steffick D, Streja E, Tamura MK, Tentori F, Tilea A, Tong L, Turf M, Wang D, Wang M, Woodside K, Wyncott A, Xin X, Zang W, Zepel L, Zhang S, Zho H, Hirth RA, Shahinian V. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2017;69(3 Suppl 1):A7–8. doi: 10.1053/j.ajkd.2016.12.004.
  92. Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A, Gallagher M, Kotwal S, Cass A, Perkovic V. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015;385(9981): 1975–82. doi: 10.1016/S0140-6736(14)61601-9.
  93. Ojo A. Addressing the global burden of chronic kidney disease through clinical and translational research. Trans Am Clin Climatol Assoc. 2014;125:229–43.
  94. WHO. Addressing gender within primary health care reforms. In: WHO, editor. Gender, women and primary health care renewal: a discussion paper [Internet]. [cited 2017 Oct 19]. Available from: http://apps.who.int/iris/bitstream/10665/44430/1/9789241564038_eng.pdf.
  95. Eguavoen ANT, Odiagbe SO, Obetoh GI. The status of women, sex preference, decision-making and fertility control in Ekpoma community of Nigeria. J Soc Sci. 2007;15(1): 43–9. doi: 10.1080/09718923.2007.11892561.
  96. Halle MP, Takongue C, Kengne AP, Kaze FF, Ngu KB. Epidemiological profile of patients with end stage renal disease in a referral hospital in Cameroon. BMC Nephrol. 2015;16:59. doi: 10.1186/s12882-015-0044-2.
  97. Ajayi S, Raji Y, Bello T, Jinadu L, Salako B. Unaffordability of renal replacement therapy in Nigeria. Hong Kong Journal of Nephrology. 2016;18(Supplement C):15–9. doi: 10.1016/j.hkjn.2015.11.002.
  98. Kausz AT, Obrador GT, Arora P, Ruthazer R, Levey AS, Pereira BJ. Late initiation of dialysis among women and ethnic minorities in the United States. J Am Soc Nephrol. 2000;11(12): 2351–7.
  99. Coresh J, Byrd-Holt D, Astor BC, Briggs JP, Eggers PW, Lacher DA, Hostetter TH. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol. 2005;16(1): 180–8. doi: 10.1681/ASN.2004070539.
  100. Adams SV, Rivara M, Streja E, Cheung AK, Arah OA, Kalantar-Zadeh K, Mehrotra R. Sex differences in hospitalizations with maintenance hemodialysis. J Am Soc Nephrol. 2017;28(9): 2721–8. doi: 10.1681/ASN.2016090986.
  101. Ethier J, Mendelssohn DC, Elder SJ, Hasegawa T, Akizawa T, Akiba T, Canaud BJ, Pisoni RL. Vascular access use and outcomes: an international perspective from the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant. 2008;23(10): 3219–26. doi: 10.1093/ndt/gfn261.
  102. Depner TA. Prescribing hemodialysis: the role of gender. Adv Ren Replace Ther. 2003;10(1): 71–7. doi: 10.1053/jarr.2003.50007.
  103. Sehgal AR. Outcomes of renal replacement therapy among blacks and women. Am J Kidney Dis. 2000;35(4 Suppl 1):S148–52. doi: 10.1016/S0272-6386(00)70242-3.
  104. Jindal RM, Ryan JJ, Sajjad I, Murthy MH, Baines LS. Kidney transplantation and gender disparity. Am J Nephrol. 2005;25(5): 474–83. doi: 10.1159/000087920.
  105. Couchoud C, Bayat S, Villar E, Jacquelinet C, Ecochard R; REIN registry. A new approach for measuring gender disparity in access to renal transplantation waiting lists. Transplantation. 2012;94(5): 513–9. doi: 10.1097/TP.0b013e31825d156a.
  106. Liu G, Li X, Liu T, Zhao X, Zhang S, Wang J, Ji C, Gan W, Guo H. Gender disparity of living donor renal transplantation in East China. Clin Transplant. 2013;27(1): 98–103. doi: 10.1111/ctr.12003.
  107. Naghibi O, Naghibi M, Nazemian F. Gender disparity in kidney transplantation. Saudi J Kidney Dis Transpl. 2008;19(4): 545–50.
  108. Bal MM, Saikia B. Gender bias in renal transplantation: are women alone donating kidneysin India? Transplant Proc. 2007;39(10): 2961–3. doi: 10.1016/j.transproceed.2007.08.089.
  109. Hogan J, Couchoud C, Bonthuis M, Groothoff JW, Jager KJ, Schaefer F, Van Stralen KJ; ESPN/ERA-EDTA Registry. Gender disparities in access to pediatric renal transplantation in Europe: data from the ESPN/ ERA-EDTA registry. Am J Transplant. 2016;16(7): 2097–105. doi: 10.1111/ajt.13723.
  110. Gillespie A, Hammer H, Kolenikov S, Polychronopoulou A, Ouzienko V, Obradovic Z, Urbanski MA, Browne T, Silva P. Sex differences and attitudes toward living donor kidney transplantation among urban black patients on hemodialysis. Clin J Am Soc Nephrol. 2014;9(10): 1764–72. doi: 10.2215/CJN.12531213.
  111. Salter ML, McAdams-Demarco MA, Law A, Kamil RJ, Meoni LA, Jaar BG, Sozio SM, Kao WH, Parekh RS, Segev DL. Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc. 2014;62(5): 843–9. doi: 10.1111/jgs.12801.
  112. Piccoli GB, Attini R, Cabiddu G, Kooij I, Fassio F, Gerbino M, Maxia S, Biolcati M, Versino E, Todros T. Maternal-foetal outcomes in pregnant women with glomerulonephritides. Are all glomerulonephritides alike in pregnancy? J Autoimmun. 2017;79:91–8. doi: 10.1016/j.jaut.2017.01.008.
  113. Seeger H, Salfeld P, Eisel R, Wagner CA, Mohebbi N. Complicated pregnancies in inherited distal renal tubular acidosis: importance of acid-base balance. J Nephrol. 2017;30(3): 455–60. doi: 10.1007/s40620-016-0370-x.
  114. Yefet E, Tovbin D, Nachum Z. Pregnancy outcomes in patients with Alport syndrome. Arch Gynecol Obstet. 2016;293(4): 739–47. doi: 10.1007/s00404-015-3893-9.

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