Email this article EPSTEIN-BARR VIRUS AND CYTOMEGALOVIRUS: IS THEIR ROLE IN PEMPHIGUS REALLY INCIDENTAL? A PRELIMINARY REPORT
- Authors: Makhneva N.V.1,2, Syuch N.I.3,4, Voronova V.V.1,2, Beletskaya L.V.1,2
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
- Medical Educational Scientific Clinical Center named after P.V. Mandryka
- 8А Bol'shaya Olen'ya ul., Moscow, 107014, Russian Federation
- Issue: Vol 44, No 1 (2016)
- Pages: 13-17
- Section: DERMATOLOGY
- URL: https://almclinmed.ru/jour/article/view/300
- DOI: https://doi.org/10.18786/2072-0505-2016-44-1-13-17
- ID: 300
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Abstract
Background: Epstein-Barr (EBV) and cytomegaloviral (CMV) infections are among most prevalent in the population worldwide that are associated with autoimmune processes. However, conflicting data of the studies on the role of herpes viral infections in the etiology of autoimmune pemphigus does not allow for reliable recognition of these viruses as triggers in the development and course of this bullous dermatosis. Aim: To assess specific IgM and IgG antibodies to herpes virus infections in patients with autoimmune pemphigus. Materials and methods: Serum samples from 15 patients with autoimmune pemphigus were analyzed by chemoluminescent immunoassay. Results: In the serum samples of 14/15 (93.3%) patients with autoimmune pemphigus we found specific IgG antibodies to nuclear and capsid EBV proteins at the levels of 30.7 to 600 U/mL (median, 147.5 [102.62; 313.25] U/mL) and from 33.5 to 567 U/mL (median, 186 [85.95; 492.5] U/mL), respectively. Specific IgG antibodies to the EBV early protein were found only in 6.7% of cases. In all patients, there were no specific IgM antibodies to EBV capsule antigens. All patients (100%) had specific IgG anti-CMV antibodies in the range from 64.5 to 138 U/mL (median, 103.5 [94.83; 113.75] U/mL). In 30% of cases, there were specific IgM anti-CMV antibodies at titers of 11 to 12.3 U/mL (median, 5 [5; 9.5] U/mL). Conclusion: The results of the preliminary study showed that 93.3% of autoimmune pemphigus cases have an underlying chronic infection caused by EBV and CMV. The finding of the high titers of IgG anti-EBV and anti-CMV antibodies allows to conclude that the association of these viruses with the bullous dermatosis is not just a chance. It makes further research undoubtedly necessary. Its results would draw more accurate conclusions on the role of EBV and CMV in the pathogenesis of autoimmune pemphigus and to find new perspectives in the treatment of patients with this life-threatening disease.
About the authors
N. V. Makhneva
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Author for correspondence.
Email: makhneva@mail.ru
MD, PhD, Professor, Chair of Dermatovenereology and Dermato-oncology, Postgraduate Training Faculty Россия
N. I. Syuch
Medical Educational Scientific Clinical Center named after P.V. Mandryka; 8А Bol'shaya Olen'ya ul., Moscow, 107014, Russian Federation
Email: makhneva@mail.ru
MD, PhD, Professor, Chair of Advanced Medical Therapy, Head of Laboratory Department Россия
V. V. Voronova
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: makhneva@mail.ru
MD, PhD Student, Chair of Dermatovenereology and Dermato-oncology, Postgraduate Training Faculty
РоссияL. V. Beletskaya
Email: makhneva@mail.ru
MD, PhD, Professor
РоссияReferences
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