Email this article CLINICAL EFFICACY OF EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS
- Authors: Molochkov A.V.1,2, Kil’dyushevskiy A.V.1,2, Karzanov O.V.1,2, Bagapsh L.S.1,2
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
- Issue: No 34 (2014)
- Pages: 15-19
- Section: DERMATOLOGY
- URL: https://almclinmed.ru/jour/article/view/159
- DOI: https://doi.org/10.18786/2072-0505-2014-34-15-19
- ID: 159
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Abstract
Aim: To assess clinical efficacy of extracorporeal photochemotherapy in patients with systemic lupus erythematosus (SLE). Materials and methods: 30 SLE patients were thoroughly examined. 16 of them received medical treatment and extracorporeal photochemotherapy (treatment group), 14 patients – routine therapy only (controls). Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UV-radiation (λ=320– 400 nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: After 3 courses of extracorporeal photochemotherapy, effect (reduced eruptions) was obtained in 14 patients (46.7%). Then, the patients underwent maintenance photochemotherapy 2–3 times a year. Conclusion: Extracorporeal photochemotherapy was effective in the treatment of SLE. Immunological studies have demonstrated pathogenetic effects of extracorporeal photochemotherapy.
About the authors
A. V. Molochkov
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: fake@neicon.ru
MD, PhD, Professor, Deputy Director on Science, Educational Work and International Communications Россия
A. V. Kil’dyushevskiy
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: fake@neicon.ru
MD, PhD, Professor, Leading Research Fellow, Surgical Hemocorrection and Detoxication Department Россия
O. V. Karzanov
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Author for correspondence.
Email: dr_karzanov@mail.ru
PhD, Senior Research Associate, Dermatovenereology and Dermato-Oncology Department Россия
L. S. Bagapsh
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: liana-bagapsh@mail.ru
Junior Research Associate, Dermatovenereology and Dermato-Oncology Departmen Россия
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