Email this article Liver transplantation in the Moscow Region: the regional project and its implementation
- Authors: Moysyuk Y.G.1, Malinovskaya Y.O.1, Bel'skikh L.V.1, Bogomolov P.O.1, Lobakov A.I.1, Ammosov А.A.1, Sidorenko A.B.1, Grigor'ev N.S.1, Kosov A.A.1
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- Issue: Vol 46, No 6 (2018)
- Pages: 572-583
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/896
- DOI: https://doi.org/10.18786/2072-0505-2018-46-6-572-583
- ID: 896
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Abstract
Rationale: Liver transplantation is the only curative treatment for diffuse end-stage liver disease and some liver neoplasms. The amount of these interventions in the Moscow Region is very low.
Aim: To analyze the results of the first series of liver transplantations done in the Moscow Regional Research and Clinical Institute (MONIKI), to compare it with those done currently in Russia and worldwide, and to establish the optimal volume and trend of development for this new regional center.
Materials and methods: More than 200 patients with liver cirrhosis, polycystosis and alveococcus invasion have been examined from May 2016 to August 2018; 70 of them were eligible for liver transplantation and were put on the waiting list. From October 2016 to July 2018, 29 liver transplantations from deceased donors (including 2 retransplantations) and one living related transplantation of the right lobe have been performed. Among the indications to the transplantation, the leading one was viral (HCV or HBV-related) cirrhosis. Four patients were diagnosed with hepatocellular carcinoma.
Results: The waitlist mortality was 19%. Median waiting time was 5.5 [3; 9] (0 to 27) months. Until now, the results were followed till 22 months, with median follow-up of 7 [2; 13] months. The survival rate of the recipients was 96.4%, of the grafts 93.3%. In-patient mortality was 3.6%. Early allograft dysfunction was seen in 33% of cases. Median length of the in-hospital stay was 22 [19; 25] days.
Conclusion: The successful implementation of the liver transplant program at its initial stage demonstrates the results that meet current efficacy criteria. Achieved level of organ procurement from deceased donors in the Moscow Region could ensure at least 30 liver transplantations annually, with current facilities and a potential for further growth. An increase in the transplantation number would depend on the improvement of transplantation service facilities in MONIKI and on the stable financial support of the program. Finally, it would promote increased availability of this transplantation technology in the region, lower waitlist mortality and shorter waiting times.
About the authors
Ya. G. Moysyuk
Moscow Regional Research and Clinical Institute (MONIKI)
Author for correspondence.
Email: moysyuktrans@list.ru
Yan G. Moysyuk – MD, PhD, Professor, Chief Research Fellow, Division of Abdominal Surgery, Department of Hepatology.
61/2–15 Shchepkina ul., Moscow, 129110, tel.: +7 (964) 640 86 16 РоссияYu. O. Malinovskaya
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Yulia O. Malinovskaya – MD, Research Fellow, Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияL. V. Bel'skikh
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Leonid V. Bel'skikh – MD, PhD, Head of the Moscow Region Organ Procurement Center.
61/2 Shchepkina ul., Moscow, 129110
РоссияP. O. Bogomolov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Pavel O. Bogomolov – MD, PhD, Head of Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияA. I. Lobakov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Aleksandr I. Lobakov – MD, PhD, Professor, Head of the Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияА. A. Ammosov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Aleksandr A. Ammosov – MD, PhD, Surgeon, Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияA. B. Sidorenko
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Aleksey B. Sidorenko – Junior Research Fellow, Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияN. S. Grigor'ev
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Nikita S. Grigor'ev – Junior Research Fellow, Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияA. A. Kosov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Artem A. Kosov – Junior Research Fellow, Division of Abdominal Surgery, Department of Hepatology.
61/2 Shchepkina ul., Moscow, 129110
РоссияReferences
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