Multiplicity of comorbidities in patients with severe psoriasis

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Rationale: Severe treatment-resistant psoriasis and comorbidities are on the rise.

Aim: To evaluate the prevalence of comorbidities in a  hospital-based cohort of patients with severe psoriases.

Materials and methods: We performed a  retrospective analysis of medical files of 890  patients with moderate-to-severe plaque psoriasis (PASI > 10) treated in a  hospital from 2010 to 2015 (men, 516 [58%], women, 374 [42%]; mean age 51.9 ± 11.6 years; mean PASI, 44.3 ± 7.8  scores).

Results: Comorbidities were found in 61% (543 / 890) of the patients with severe psoriasis, with cardiovascular disorders ranking first (59%, or 516 / 890) and gastrointestinal and hepatobiliary disorders ranking second (46,4%, or 413 / 890). Psoriatic arthritis was diagnosed in 34% (303 / 890) of the patients and other disorders of the musculoskeletal system unrelated to psoriasis in 19.8% (176 / 890). The proportion of diabetes was 15.4% (137 / 890).

Conclusion: Psoriasis has a high rate of comorbidities, in particular of cardiovascular disorders. It significantly deteriorates the course of psoriasis and its response to therapy, and in some cases may reduce the possibility of adequate anti-psoriatic treatment due to contraindications.

About the authors

N. V. Batkaeva

Peoples' Friendship University of Russia (RUDN University)

Author for correspondence.

Nadezhda V. Batkaeva – MD, PhD, Associate Professor, Chair of Dermatovenereology and Cosmetology, Faculty for Advanced Training of Medical Workers, Institute of Medicine.

6 Miklukho-Maklaya ul., Moscow, 117198, +7 (903) 770 30 44

Russian Federation

T. V. Korotaeva

V.A. Nasonova Research Institute of Rheumatology


Tatyana V. Korotaeva – MD, PhD, Leading Research Fellow, Laboratory of Innovative Methods for Diagnosis and Treatment of Psoriatic Arthritis.

34A Kashirskoye shosse, Moscow, 115522

Russian Federation

E. A. Batkaev

Peoples' Friendship University of Russia (RUDN University)


Edgem A. Batkaev – MD, PhD, Professor, Head of the Chair of Dermatovenereology and Cosmetology, Faculty for Advanced Training of Medical Workers, Institute of Medicine.

6 Miklukho-Maklaya ul., Moscow, 117198

Russian Federation


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Copyright (c) 2018 Batkaeva N.V., Korotaeva T.V., Batkaev E.A.

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