The role of hereditary colorectal cancer registries in identification of high risk patients and treatment improvement

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Abstract

Up to 10% of cases of sporadic colorectal cancer are considered to be related to hereditary genetic factors. The rates of colorectal cancer related to already identified genetic factors is about 5%. In the last decades, due to the development of comprehensive familial cancer registries and progress in genomics, clinical diagnostic criteria for specific hereditary syndromes have been proposed and multiple genes have been detected whose germ mutations increase the risk of neoplastic syndromes. Identification of individual patients and families with hereditary syndromes (familial adenomatous polyposis, Lynch syndrome, MYH-associated polyposis, hamartoma syndromes) may help to develop an effective strategy for monitoring and, as the results, for reduction of cancer incidence and improvement of survival. The aim of this literature review is to assess the influence of the registries of patients with hereditary types of colorectal cancer on its incidence and long-term treatment results.

About the authors

D. Yu. Pikunov

State Scientific Centre of Coloproctology

Author for correspondence.
Email: pikunov.gnck@mail.ru

Dmitriy Yu. Pikunov – MD, PhD, Research Associate, Department of Oncoproctology.

2 Salyama Adilya ul., Moscow, 123423, +7 (499) 199 25 54 Russian Federation

M. Kh. Toboeva

Russian Medical Academy of Continuous Professional Education

Email: fake@neicon.ru

Margarita Kh. Toboeva – MD, Chair of Coloproctology.

2/1 Barrikadnaya ul., Moscow, 125993

Russian Federation

A. S. Tsukanov

State Scientific Centre of Coloproctology

Email: fake@neicon.ru

Aleksey S. Tsukanov – MD, PhD, Head of Department of Clinical Genetic

Salyama Adilya ul., Moscow, 123423

Russian Federation

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Copyright (c) 2018 Pikunov D.Y., Toboeva M.K., Tsukanov A.S.

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