Successful treatment of periodic disease and secondary AA amyloidosis in a colchicine-resistant patient

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Abstract

The paper demonstrates current opportunities of effective management of periodic disease as an autoinflammatory disorder based on a clinical case of colchicine-resistant Mediterranean fever. We present modern approaches to the autoinflammation hypothesis and its molecular mechanisms in periodic disease. Based on literature and our own research results, we consider approaches to evaluate autoinflammation activity and to monitor treatment efficacy. Clinical value of S100A12, a novel marker of the activity of neutrophilic autoinflammation, is demonstrated. 

About the authors

V. V. Rameev

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: vvrameev@mail.ru

MD, PhD, Associate Professor, Chair of Internal Medicine and Occupational Medicine, Faculty of Preventive Medicine

11/5 Rossolimo ul., Moscow, 119435

Tel.: +7 (910) 493 61 38

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation

M. V. Bogdanova

Lomonosov Moscow State University

Email: fake@neicon.ru

MD, PhD, Assistant, Chair of Internal Medicine, Faculty of Fundamental Medicine

1 Leninskie Gory, Moscow, 119991

Russian Federation

L. V. Kozlovskaya

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

MD, PhD, Professor, Chief Research Fellow, Chair of Internal Medicine and Occupational Medicine, Faculty of Preventive Medicine

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation

N. A. Mukhin

I.M. Sechenov First Moscow State Medical University; Lomonosov Moscow State University

Email: fake@neicon.ru

MD, PhD, Professor, Member of Russian Academy of Sciences, Head of the Chair of Internal Medicine and Occupational Medicine, Faculty of Preventive Medicine

Head of the Chair of Internal Medicine, Faculty of Fundamental Medicine

8/2 Trubetskaya ul., Moscow, 119991

1 Leninskie Gory, Moscow, 119991

Russian Federation

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Copyright (c) 2017 Rameev V.V., Bogdanova M.V., Kozlovskaya L.V., Mukhin N.A.

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