Classification, regulation of activity, and genetic polymorphism of matrix metalloproteinases in health and disease

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Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that catalyze the degradation reactions of the extracellular matrix components. In humans, 23 enzymes of this family are known, which are subdivided into 6 groups based on their structure and substrate types: collagenases, gelatinases, stromelysins, matrilizines, MMP membrane type and other MMPs. MMP functions are diverse, and an imbalance of their activity may be one of the etiological factors of various diseases. The review considers classification, regulation of activity and genetic polymorphism of matrix metalloproteinases in health and in various pathological processes in the human body. A list of the most studied polymorphic variants of MMP genes is given, their functional effects are described and the results of associative studies are presented.

About the authors

A. S. Shadrina

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences

Author for correspondence.
Email: weiner.alexserg@gmail.com

PhD (in Biology), Junior Researcher, Laboratory of Pharmacogenomics

8 Akademika Lavrent'eva prosp., Novosibirsk, 630090, Russian Federation. Tel.: +7 (383) 363 51 71

Россия

Ya. Z. Plieva

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: fake@neicon.ru

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

Россия

D. N. Kushlinskiy

N.N. Blokhin Russian Cancer Research Center

Email: fake@neicon.ru

MD, PhD, Surgeon/Gynecologist

24 Kashirskoe shosse, Moscow, 115478, Russian Federation

Россия

A. A. Morozov

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: fake@neicon.ru

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

Россия

M. L. Filipenko

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences

Email: fake@neicon.ru

PhD (in Biology), Head of Laboratory of Pharmacogenomics

8 Akademika Lavrent'eva prosp., Novosibirsk, 630090, Russian Federation

Россия

V. L. Chang

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: fake@neicon.ru

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

Россия

N. E. Kushlinskii

N.N. Blokhin Russian Cancer Research Center

Email: fake@neicon.ru

MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Head of Clinical Biochemistry Laboratory

24 Kashirskoe shosse, Moscow, 115478, Russian Federation

Россия

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Copyright (c) 2017 Shadrina A.S., Plieva Y.Z., Kushlinskiy D.N., Morozov A.A., Filipenko M.L., Chang V.L., Kushlinskii N.E.

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