Email this article EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM
- Authors: Kulikova P.A.1, Filyushkin Y.N.2, Kulikov D.A.3, Fedulov A.V.2, Mashkov A.E.2, Kulikov A.V.4
-
Affiliations:
- Lomonosov Moscow State University Moscow Regional Research and Clinical Institute (MONIKI)
- Moscow Regional Research and Clinical Institute (MONIKI)
- Moscow Regional Research and Clinical Institute (MONIKI) Institute of Theoretical and Experimental Biophysics of RAS
- Institute of Theoretical and Experimental Biophysics of RAS
- Issue: No 31 (2014)
- Pages: 21-24
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/53
- DOI: https://doi.org/10.18786/2072-0505-2014-31-21-24
- ID: 53
Cite item
Full Text
Abstract
Background: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conducted on the male Wistar rats, hypogonadism was modeled by temporary ligation of the distal part of the spermatic cord. Results: It was shown that three-day ligation of the spermatic cord led to persistent disturbance of the testosterone-producing and reproductive functions. These manifestations were reversible at shorter duration of the exposure. Conclusion: The created model of primary male hypogonadism is characterized by the persistent testosterone-producing and reproductive functions disturbance, technical availability, non-toxicity to the other organs and systems. Availability of the model provides new opportunities for the development of approaches to treating diseases of the reproductive organs in men.
Keywords
About the authors
P. A. Kulikova
Lomonosov Moscow State UniversityMoscow Regional Research and Clinical Institute (MONIKI)
Author for correspondence.
Email: polinikul@mail.ru
laboratory worker of the Laboratory of Medical and Physics Research, MONIKI; student of the Faculty of Fundamental Medicine, MSU Россия
Yu. N. Filyushkin
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
scientific worker, researcher of the Pediatric Surgery Department, MONIKI Россия
D. A. Kulikov
Moscow Regional Research and Clinical Institute (MONIKI)Institute of Theoretical and Experimental Biophysics of RAS
Email: fake@neicon.ru
PhD, senior researcher of the Laboratory of Medical and Physics Research, MONIKI; researcher of the laboratory of Isotopic Investigations, ITEB of RAS Россия
A. V. Fedulov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Resident Medical Practitioner of the Pediatric Surgery Department, MONIKI Россия
A. E. Mashkov
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
MD, PhD, Professor, Head of the Pediatric Surgery Department, MONIKI Россия
A. V. Kulikov
Institute of Theoretical and Experimental Biophysics of RAS
Email: fake@neicon.ru
MD, PhD, Head of the Experimental Transplantology Department, Scientific secretary, ITEB of RAS Россия
References
- Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: ГЭОТАР-Медиа; 2007. [Dedov I.I., Mel’nichenko G.A., Fadeev V.V. Endocrinology. Moscow: GEOTAR-Media; 2007 (in Russian)].
- Dohle G.R., Arver S., Bettocchi C., Kliesch S., Punab M., de Ronde W. Guidelines on male hypogonadism. Arnhem (The Netherlands): European Association of Urology; 2012.
- Huhtaniemi I. Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment. Asian J Androl 2014;16(2):192-202.
- Corona G., Rastrelli G., Monami M., Guay A., Buvat J., Sforza A., Forti G., Mannucci E., Maggi M. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. Eur J Endocrinol 2011;165(5):687-701.
- Kliesch S. Testosterone and infertility. Urologe A 2010; 49(1):32-6.
- Jungwirth A., Diemer T., Dohle G.R., Giwercman A., Kopa Z., Tournaye H., Krausz C. Guidelines on male infertility. Arnhem (The Netherlands): European Association of Urology; 2013.
- Sukhikh G.T., Kamalov A.A., Poltavtseva R.A., Zaraiskii E.I., Plotnikov E.Y., Kirpatovskii V.I., Efremov E.A., Orlova E.V., Pavlova G.V., Okhobotov D.A. Effect of xenotransplantation of cell cultures enriched with stem and progenitor cells on hormonal profile of rats with abdominal cryptorchism. Bull Exp Biol Med 2008;146(4):517-21.
- Zhang Z., Shao S., Meistrich M.L. Irradiated mouse testes efficiently support spermatogenesis derived from donor germ cells of mice and rats. J Androl 2006;27(3):365-75.
- Meistrich M.L. Male gonadal toxicity. Pediatr Blood Cancer 2009;53(2):261-6.
- Swerdloff R.S., Lue Y., Liu P.Y., Erkkilä K., Wang C. Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder. Acta Paediatr 2011;100(6):892-9.
- Yuluğ E., Türedi S., Karagüzel E., Kutlu O., Menteşe A., Alver A. The short term effects of resveratrol on ischemia-reperfusion injury in rat testis. J Pediatr Surg 2014;49(3):484-9.
- Западнюк И.П., Западнюк В.И., Захария Е.А. Лабораторные животные. Киев: Выща школа, 1974. [Zapadnyuk I.P., Zapadnyuk V.I., Zakhariya E.A. Laboratory animals. Kiev: Vyshcha shkola; 1974 (in Russian)].
Supplementary files
