THE SIGNIFICANCE OF BREASTFEEDING FOR THE INFANT GROWTH AND DEVELOPMENT: A REVIEW

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Abstract

Based on the literature, the review shows the real value of breast milk as the most optimal type of postnatal feeding of infants. We describe biological mechanisms that are supposed to mediate  the influence of breastfeeding on maturation of  immune response, regulation of intestinal functions, trophic effect on small and large intestinal  mucosa, its microflora and somatic growth of an  infant. In infancy, the protective properties of  breast milk against intestinal infections are largely related to its prebiotic effect. According to the  results of the studies on the structure of the milk  fat mycella envelope, their protein not only participate in bacterial adhesion, but also exert substantial anti-microbial activity due to presence of  antimicrobial components. We discuss the role  of protective nutrients, such as zinc, iron, iodine,  selenium and vitamin A and review the results of studies performed in various countries and aimed at evaluation of an association between the type of feeding of an infant in the 1  year of life and the risk of development of somatic abnormalities. A strong influence of micronutrient deficiencies in the pregnant and breastfeeding woman on delay of in utero development has been shown, as well as its contribution to formation of congenital ab- st normalities of any organ or system, connective  tissue dysplasia, initiation and development of alimentary-related conditions in infants.

About the authors

N. I. Ursova

Moscow Regional Research and Clinical Institute

Author for correspondence.
Email: ursovan@mail.ru
Ursova Nataliya I. – MD, PhD, Professor, Head of Department of Pediatrics; Head of Chair of Pediatrics,  Postgraduate Training Faculty; Chief Pediatrician of the Ministry of Health of the Moscow Region Россия

References

  1. Walker A. Breast milk as the gold standard for protective nutrients. J Pediatr. 2010;156(2 Suppl):S3–7. doi: 10.1016/j.jpeds.2009.11.021.
  2. Belfort MB, Rifas-Shiman SL, Kleinman KP, Guthrie LB, Bellinger DC, Taveras EM, Gillman MW, Oken E. Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity. JAMA Pediatr. 2013;167(9):836–44.
  3. Hanson LA, Korotkova M, Lundin S, Håversen L, Silfverdal SA, Mattsby-Baltzer I, Strandvik B, Telemo E. The transfer of immunity from mother to child. Ann N Y Acad Sci. 2003;987:199–206.
  4. Hanson LA. Immunobiology of human milk: how breastfeeding protects babies. Amarillo, TX: Pharmasoft Publishing; 2004. 246 p.
  5. Lönnerdal B. Novel insights into human lactation as a driver of infant formuladevelopment. Nestle Nutr Workshop Ser Pediatr Program. 2010;66:19–29. doi: 10.1159/000318945.
  6. Liao Y, Alvarado R, Phinney B, Lönnerdal B. Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period. J Proteome Res. 2011;10(8):3530–41. doi: 10.1021/pr200149t.
  7. Martín R, Jiménez E, Heilig H, Fernández L, Marín ML, Zoetendal EG, Rodríguez JM. Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR. Appl Environ Microbiol. 2009;75(4):965–9. doi: 10.1128/AEM.02063-08.
  8. Chouraqui JP, Grathwohl D, Labaune JM, Hascoet JM, de Montgolfier I, Leclaire M, Giarre M, Steenhout P. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am J Clin Nutr. 2008;87(5):1365–73.
  9. Sienkiewicz G, Ljunggren L. Occurrence of Lactobacillus reuteri in human breast microbial ecology. Health and disease. 2008;20:122–6.
  10. Bourlioux P, Koletzko B, Guarner F, Braesco V. The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium “The Intelligent Intestine”, held in Paris, June 14, 2002. Am J Clin Nutr. 2003;78(4):675–83.
  11. Matsumoto M, Tani H, Ono H, Ohishi H, Benno Y. Adhesive property of Bifidobacterium lactis LKM512 and predominant bacteria of intestinal microflora to human intestinal mucin. Curr Microbiol. 2002;44(3):212–5.
  12. Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr. 1999;69(5): 1035S–1045S.
  13. Wold AE, Adlerberth I. Breast feeding and the intestinal microflora of the infant – implications for protection against infectious diseases. Adv Exp Med Biol. 2000;478:77–93.
  14. Mack DR, Ahrne S, Hyde L, Wei S, Hollingsworth MA. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut. 2003;52(6):827–33.
  15. Duffy LC. Interactions mediating bacterial translocation in the immature intestine. J Nutr. 2000;130(2S Suppl):432S–436S.
  16. Patton S. MUC1 and MUC-X, epithelial mucins of breast and milk. Adv Exp Med Biol. 2001;501:35–45.
  17. Quigley MA, Kelly YJ, Sacker A. Breastfeeding and hospitalization for diarrheal and respiratory infection in the United Kingdom Millennium Cohort Study. Pediatrics. 2007;119(4):e837–42.
  18. Liu YJ, Kadowaki N, Rissoan MC, Soumelis V. T cell activation and polarization by DC1 and DC2. Curr Top Microbiol Immunol. 2000;251:149–59.
  19. Отт ВД, Марушко ТЛ. Иммунобиологическая роль женского молозива и молока. Педиатрия. 1985;(10):72–5.
  20. Холодова ИН, Ильенко ЛИ, Демин ВФ, Сул- танова ОД. Перспективы в диагностике и лечении дисбиотических нарушений кишечника у детей. Поликлиника. 2003;(1): 16–7.
  21. Bergmann RL, Diepgen TL, Kuss O, Bergmann KE, Kujat J, Dudenhausen JW, Wahn U; MAS-study group. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy. 2002;32(2):205–9.
  22. Bernt KM, Walker WA. Human milk as a carrier of biochemical messages. Acta Paediatr Suppl. 999;88(430):27–41.
  23. Hanson LA, Korotkova M. The role of breastfeeding in prevention of neonatal infection. Semin Neonatol. 2002;7(4):275–81.
  24. Field CJ. The immunological components of human milk and their effect on immune development in infants. J Nutr. 2005;135(1): 1–4.
  25. Железная ЛА. Структура и функция гликопротеинов слизи (муцинов). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 1998;8(1):30–7.
  26. Espinoza J, Clark SB, Hritz A, Rosensweig NS. Regulation of rat proximal intestinal glycolytic enzyme activity by ileal perfusion with glucose. Gastroenterology. 1976;71(2):295–8.
  27. Baker HM, Anderson BF, Kidd RD, Shewry SC, Baker EN. Lactoferrin three-dimensional structure: a framework for interpreting function. In: Shimazaki K, editor. Lactoferrin: structure, function and application. Amsterdam: Elsevier Science; 2000. p. 3–15.
  28. Lönnerdal B. Bioactive proteins in human milk: mechanisms of action. J Pediatr. 2010;156(2 Suppl):S26–30. doi: 10.1016/j. jpeds.2009.11.017.
  29. Hernell O. Human milk vs. cow's milk and the evolition of infant formulas. In: Clemens RA, Hernell O, Mickaelsen KF, editors. Milk and milk products in human nutrition. Nestle Nutr Ints Workshop ser Pediatr Program Vevey, Nestle. Karger-Bazel. 2011;67:17–25.
  30. Карпунина ТИ, Горовиц ЭС, Чиненкова АН, Перевалов АЯ. Повышение эффективности терапевтического действия пробиотиков. Журнал микробиологии, эпидемиологии и иммунологии. 1998;(2):104–7.
  31. Goldman AS. Modulation of the gastrointestinal tract of infants by human milk. Interfaces and interactions. An evolutionary perspective. J Nutr. 2000;130(2S Suppl): 426S–431S.
  32. Мейл Д, Бростофф Дж, Рот ДБ, Ройтт А. Иммунология. М.: Логосфера; 2007. 568 с.
  33. Martín R, Langa S, Reviriego C, Jiménez E, Marín ML, Olivares M, Boza J, Jiménez J, Fernández L, Xaus J, Rodríguez JM. The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics. Trends Food Sci Technol. 2004;15:121–7.
  34. Garside P, Mowat AM. Oral tolerance. Semin Immunol. 2001;13(3):177–85.
  35. Kursar M, Bonhagen K, Fensterle J, Köhler A, Hurwitz R, Kamradt T, Kaufmann SH, Mittrücker HW. Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J Exp Med. 2002;196(12):1585–92.
  36. Elson CO, Cong Y, Iqbal N, Weaver CT. Immunobacterial homeostasis in the gut: new insights into an old enigma. Semin Immunol. 2001;13(3):187–94.
  37. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest. 2003;111(7):1065–72.
  38. Nagata S, McKenzie C, Pender SL, BajajElliott M, Fairclough PD, Walker-Smith JA, Monteleone G, MacDonald TT. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J Immunol. 2000;165(9):5315–21.
  39. Dai D, Walker WA. Protective nutrients and bacterial colonization in the immature human gut. Adv Pediatr. 1999;46:353–82.
  40. Schlimme E, Martin D, Meisel H. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Br J Nutr. 2000;84 Suppl 1:S59–68.
  41. Brunser O, Espinoza J, Araya M, Cruchet S, Gil A. Effect of dietary nucleotide supplementation on diarrhoeal disease in infants. Acta Paediatr. 1994;83(2):188–91.
  42. Kalliomäki M, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol. 2003;3(1):15–20.
  43. Шаафсма А. Нуклеотиды в питании детей грудного возраста. Педиатрия. 2006;(4): 56–61.
  44. Rotimi VO, Duerden BI. The development of the bacterial flora in normal neonates. J Med Microbiol. 1981;14(1):51–62.
  45. Gnoth MJ, Kunz C, Kinne-Saffran E, Rudloff S. Human milk oligosaccharides are minimally digested in vitro. J Nutr. 2000;130(12):3014–20.
  46. Böttcher MF, Jenmalm MC, Garofalo RP, Björkstén B. Cytokines in breast milk from allergic and nonallergic mothers. Pediatr Res. 2000;47(1):157–62.
  47. Langhendries JP, Detry J, Van Hees J, Lamboray JM, Darimont J, Mozin MJ, Secretin MC, Senterre J. Effect of a fermented infant formula containing viable bifidobacteria on the fecal flora composition and pH of healthy full-term infants. J Pediatr Gastroenterol Nutr. 1995;21(2):177–81.
  48. Bode L. Recent advances on structure, metabolism, and function of human milk oligosaccharides. J Nutr. 2006;136(8):2127–30.
  49. Boehm G, Stahl B. Oligosaccharides. In: Mattila- Sandholm T, editor. Functional dairy products. Cambridge: Woodhead; 2003. p. 203–43.
  50. Morrow AL, Ruiz-Palacios GM, Jiang X, Newburg DS. Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea. J Nutr. 2005;135(5):1304–7.
  51. Ruiz-Palacios GM, Cervantes LE, Ramos P, Chavez-Munguia B, Newburg DS. Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J Biol Chem. 2003;278(16):14112–20.
  52. Carlson SE, Colombo J, Gajewski BJ, Gustafson KM, Mundy D, Yeast J, Georgieff MK, Markley LA, Kerling EH, Shaddy DJ. DHA supplementation and pregnancy outcomes. Am J Clin Nutr. 2013;97(4):808–15. doi: 10.3945/ajcn.112.050021.
  53. Field CJ, Van Aerde JE, Robinson LE, Clandinin MT. Feeding a formula supplemented with long chain polyunsaturated fatty acids modifies the "ex vivo" cytokine responses to food proteins in infants at low risk for allergy. Pediatr Res. 2008;64(4):411–7. doi: 10.1203/ PDR.0b013e318181b391.
  54. Dewey KG. Nutrition, growth, and complementary feeding of the breastfed infant. Pediatr Clin North Am. 2001;48(1):87–104.
  55. Udipi SA, Ghugre P, Antony U. Nutrition in pregnancy and lactation. J Indian Med Assoc. 2000;98(9):548–57.
  56. Frederickson CJ, Suh SW, Silva D, Frederickson CJ, Thompson RB. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr. 2000;130(5S Suppl):1471S–83S.
  57. Colvin RA, Davis N, Nipper RW, Carter PA. Zinc transport in the brain: routes of zinc influx and efflux in neurons. J Nutr. 2000;130(5S Suppl):1484S–7S.
  58. Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, Vaughan JP. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ. 2002;325(7372):1059.
  59. Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, Sommerfelt H. Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. J Pediatr. 2002;141(5):677–82.
  60. Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, Fuchs G, Mahalanabis D. Single dose vitamin A treatment in acute shigellosis in Bangladesh children: randomised double blind controlled trial. BMJ. 1998;316(7129):422–6.
  61. Fawzi WW, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. J Pediatr. 2000;137(5):660–7.
  62. Warden RA, Strazzari MJ, Dunkley PR, O'Loughlin EV. Vitamin A-deficient rats have only mild changes in jejunal structure and function. J Nutr. 1996;126(7):1817–26.
  63. Geissmann F, Revy P, Brousse N, Lepelletier Y, Folli C, Durandy A, Chambon P, Dy M. Retinoids regulate survival and antigen presentation by immature dendritic cells. J Exp Med. 2003;198(4):623–34.
  64. Hoag KA, Nashold FE, Goverman J, Hayes CE. Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigenpresenting cells. J Nutr. 2002;132(12):3736–9.
  65. Georgieff MK, Wewerka SW, Nelson CA, Deregnier RA. Iron status at 9 months of infants with low iron stores at birth. J Pediatr. 2002;141(3):405–9.
  66. Krebs NF. Dietary zinc and iron sources, physical growth and cognitive development of breastfed infants. J Nutr. 2000;130(2S Suppl):358S–360S.
  67. Hay G, Sandstad B, Whitelaw A, BorchIohnsen B. Iron status in a group of Norwegian children aged 6–24 months. Acta Paediatr. 2004;93(5):592–8.
  68. Andrews NC. Mammalian iron homeostasis. In: Iron metabolism and related disorders. Chavannes-de-Bogis, Geneva; 2002. p. 7–15.
  69. WHO, UNICEF, UNU. Iron deficiency anaemia. Assessment, prevention, and control: a guide for programme managers. Geneva: WHO; 2001.
  70. Серов ВН, Орджоникидзе НВ. Анемия – акушерские и перинатальные аспекты. Русский медицинский журнал. 2004;(1):12–5.
  71. Воробьев ПА, ред. Анемический синдром в клинической практике. М.: Ньюсдиамед; 2001. 168 с.
  72. DeMaeyer EM, Dallman P, Gurney JM, Hallberg L, Sood SK, Srikantia SG. Preventing and controlling iron deficiency anemia through primary health care. A guide for Health administrators and program managers. Geneva: World Health Organization; 1989. 87 p.
  73. Breymann C. Iron deficiency and anaemia in pregnancy: modern aspects of diagnosis and therapy. Blood Cells Mol Dis. 2002;29(3):506–16.
  74. Амонов ИИ. Клиническая оценка микроэлементного статуса крови при железодефицитной анемии у беременных. Вопросы гинекологии, акушерства и перинатологии. 2004;3(1):69–73.
  75. Сокур ТН, Бурлев ВА, Коноводова ЕН, Федорова ЮВ. Железодефицитная анемия и беременность. Роль меди и марганца в метаболизме железа. Поликлиника. 2013;(1):57–60.
  76. Мальцев СВ, Шакирова ЭМ, Халитова ДИ, Сафина ЛЗ. Безопасный способ профилактики дефицита железа у матерей и их новорожденных. Практическая медицина. 2012;(7):109–13.
  77. Ponka P. Iron metabolism: physiology and pathophysiology. J Trace Elem Exp Med. 2006;13(1):73–83.
  78. Andelman MB, Sered BR. Utilization of dietary iron by term infants. A study of 1,048 infants from a low socioeconomic population. Am J Dis Child. 1966;111(1):45–55.
  79. Roncagliolo M, Garrido M, Walter T, Peirano P, Lozoff B. Evidence of altered central nervoussystem development in infants with iron deficiency anemia at 6 months: delayed maturation of auditory brainstem responses. Am J Clin Nutr. 1998;68(3):683–90.
  80. Walter T. Impact of iron deficiency on cognition in infancy and childhood. Eur J Clin Nutr. 1993;47(5):307–16.
  81. Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006;160(11):1108–13.
  82. Касаткина ЭП, Самсонова ЛН. Эффективность йодной профилактики России: пути оптимизации. Проблемы эндокринологии. 2009;55(1):8–10.
  83. Arthur JR, McKenzie RC, Beckett GJ. Selenium in the immune system. J Nutr. 2003;133(5 Suppl 1):1457S–9S.
  84. Козлова СН, Босых ОВ. Актуальные проблемы разработки стратегии в области перинатальной нутрициологии. В: Материалы Уральской научно-практической конференции «Региональная политика в области здорового питания и применения микронутриентов в формировании здоровья населения». Екатеринбург; 2003. с. 98–109.
  85. Тимофеева НМ. Дефицит белка в периоды пренатального или раннего постнатального развития определяет здоровье потомства во взрослой жизни. Вопросы детской диетологии. 2004;2(1):79.
  86. Loy SL, Marhazlina M, Azwany YN, Hamid Jan JM. Higher intake of fruits and vegetables in pregnancy is associated with birth size. Southeast Asian J Trop Med Public Health. 2011;42(5):1214–23.
  87. Георгиева ОГ, Гмошинская МВ. Проблемы оптимизации питания беременных и кормящих женщин и роль специализированных продуктов отечественного производства. Вопросы детской диетологии. 2007;5(4):15–20.
  88. Салимова ИВ, Конь ИЯ, Гмошинская МВ, Демкина ЕЮ. Клинико-физиологическая оценка применения специализированного продукта питания для беременных женщин. Вопросы современной педиатрии. 2012;11(1):103–6.
  89. Myhre R, Brantsæter AL, Myking S, Gjessing HK, Sengpiel V, Meltzer HM, Haugen M, Jacobsson B. Intake of probiotic food and risk of spontaneous preterm delivery. Am J Clin Nutr. 2011;93(1):151–7. doi: 10.3945/ ajcn.110.004085.
  90. Luoto R, Laitinen K, Nermes M, Isolauri E. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr. 2010;103(12):1792–9. doi: 10.1017/ S0007114509993898.
  91. Champ M, Hoebler C. Functional food for pregnant, lactating women and in perinatal nutrition: a role for dietary fibres? Curr Opin Clin Nutr Metab Care. 2009;12(6):565–74. doi: 10.1097/MCO.0b013e328331b4aa.

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