Вocavirus infection in children with acute gastroenteritis

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Abstract

The review presents the data on the most important causative factors of acute gastroenteritis in children and on relatively new pathogens, such as bocavirus (HBoV), considering modern potential for verification of viral disorders. Human HBoV, belonging to Parvoviridae family, has been isolated from nasopharyngeal discharge in children with acute respiratory viral infection in 2005. Later on it was registered as a respiratory pathogen. Despite symptoms of an acute respiratory disease, HBoVinfected patients frequently present with acute gastroenteritis. In various regions of the world, fecal HBoV DNA has been found in children with acute intestinal infection by means of the polymerase chain reaction and subsequent sequencing. Molecular genetic studies showed the presence of 4 genetically different viral types. HBoV genotype 1 is more frequently found in nasopharyngeal smears from children with acute respiratory viral infection, whereas HBoV genotypes 2, 3, and 4 are isolated from feces in those with acute gastroenteritis. If HBoV is an intestinal pathogen, remain an unresolved issue. There is a  high rate of HBoV co-infection (up to 60% and more) with other intestinal viruses in children with acute gastroenteritis. High fecal DNA titers found in the studies in children with acute gastroenteritis have shown that HBoV is not only present in the bowel, but also is replicating there. The importance of studies on characteristics of molecular evolution of bocavirus is undoubted, while there are gaps in knowledge on its life cycle, mechanisms of genome replication; there is neither cultivation technique for this virus, nor animal models for disorders it may cause. The assay for anti-HBoV detection in human serum has been studied only in acute respiratory disease; high rates of HBoV seropositive patients and high antibody titers have been found in children correlating with a high viral load. It could be relevant to study prevalence and genetic variance of HВoV associated with acute gastroenteritis in various territories of the Russian Federation, because the international database GenBank does not have any genomic sequences of bocavirus isolated found in Russia. Investigation of molecular epidemiological and clinical characteristics of bocaviral infection in children with acute intestinal infection seems promising.

About the authors

E. I. Krasnova

Novosibirsk State Medical University

Author for correspondence.
Email: krasnova-inf@rambler.ru

MD, PhD, Professor, Head of the Chair of Infectious Diseases, Faculty of Pediatrics,

52 Krasnyy prospekt, Novosibirsk, Novosibirskaya oblast', 630091

Россия

A. I. Tyumentsev

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Junior Research Fellow, Laboratory of Molecular Microbiology,

8 Akademika Lavrent'eva prospekt, Novosibirsk, Novosibirskaya oblast', 630090

Россия

N. V. Tikunova

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

PhD, Doctor of Biol. Sci., Head of Laboratory of Molecular Microbiology,

8 Akademika Lavrent'eva prospekt, Novosibirsk, Novosibirskaya oblast', 630090

Россия

N. I. Khokhlova

Novosibirsk State Medical University

Email: fake@neicon.ru

MD, PhD, Associate Professor, Chair of Infectious Diseases, Faculty of Pediatrics,

52 Krasnyy prospekt, Novosibirsk, Novosibirskaya oblast', 630091

Россия

V. V. Provorova

Novosibirsk State Medical University

Email: fake@neicon.ru

MD, PhD, Associate Professor, Chair of Infectious Diseases, Faculty of Pediatrics,

52 Krasnyy prospekt, Novosibirsk, Novosibirskaya oblast', 630091

Россия

References

  1. Trinh C, Prabhakar K. Diarrheal diseases in the elderly. Clin Geriatr Med. 2007;23(4):833–56, vii. doi: 10.1016/j.cger.2007.06.005.
  2. Горелов АВ, Усенко ДВ. Ротавирусная инфекция у детей. Вопросы современной педиатрии. 2008;7(6):78–84.
  3. Arthur JL, Higgins GD, Davidson GP, Givney RC, Ratcliff RM. A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog. 2009;5(4):e1000391. doi: 10.1371/journal.ppat.1000391.
  4. Iritani N, Seto Y, Kubo H, Murakami T, Haruki K, Ayata M, Ogura H. Prevalence of Norwalk-like virus infections in cases of viral gastroenteritis among children in Osaka City, Japan. J Clin Microbiol. 2003;41(4):1756–9. doi: 10.1128/JCM.41.4.1756-1759.2003.
  5. Oh DY, Gaedicke G, Schreier E. Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol. 2003;71(1):82–93. doi: 10.1002/jmv.10449.
  6. Zhirakovskaia EV, Tikunov AY, Bodnev SA, Klemesheva VV, Netesov SV, Tikunova NV. Molecular epidemiology of noroviruses associated with sporadic gastroenteritis in children in Novosibirsk, Russia, 2003-2012. J Med Virol. 2015;87(5): 740–53. doi: 10.1002/jmv.24068.
  7. Guix S, Caballero S, Villena C, Bartolomé R, Latorre C, Rabella N, Simó M, Bosch A, Pintó RM. Molecular epidemiology of astrovirus infection in Barcelona, Spain. J Clin Microbiol. 2002;40(1): 133–9. doi: 10.1128/JCM.40.1.133-139.2002.
  8. Ratcliff RM, Doherty JC, Higgins GD. Sensitive detection of RNA viruses associated with gastroenteritis by a hanging-drop single-tube nested reverse transcription-PCR method. J Clin Microbiol. 2002;40(11):4091–9. doi: 10.1128/JCM.40.11.4091-4099.2002.
  9. Тикунов АЮ, Жираковская ЕВ, Юн ТЭ, Боднев СВ, Нетесов СВ, Тикунова НВ. Молекулярно-генетическая характеристика астровирусов, циркулирующих в Новосибирске. Вопросы вирусологии. 2010;55(6):19–23.
  10. Maldonado Y, Cantwell M, Old M, Hill D, Sanchez ML, Logan L, Millan-Velasco F, Valdespino JL, Sepulveda J, Matsui S. Population-based prevalence of symptomatic and asymptomatic astrovirus infection in rural Mayan infants. J Infect Dis. 1998;178(2):334–9.
  11. Jamieson FB, Wang EE, Bain C, Good J, Duckmanton L, Petric M. Human torovirus: a new nosocomial gastrointestinal pathogen. J Infect Dis. 1998;178(5):1263–9.
  12. Rosen BI, Fang ZY, Glass RI, Monroe SS. Cloning of human picobirnavirus genomic segments and development of an RT-PCR detection assay. Virology. 2000;277(2):316–29. doi: 10.1006/viro.2000.0594.
  13. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005;102(36):12891–6. doi: 10.1073/pnas.0504666102.
  14. Gurda BL, Parent KN, Bladek H, Sinkovits RS, DiMattia MA, Rence C, Castro A, McKenna R, Olson N, Brown K, Baker TS, Agbandje-McKenna M. Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae. J Virol. 2010;84(12):5880–9. doi: 10.1128/JVI.02719-09.
  15. Qu XW, Duan ZJ, Qi ZY, Xie ZP, Gao HC, Liu WP, Huang CP, Peng FW, Zheng LS, Hou YD. Human bocavirus infection, People's Republic of China. Emerg Infect Dis. 2007;13(1):165–8. doi: 10.3201/eid1301.060842.
  16. Ma X, Endo R, Ishiguro N, Ebihara T, Ishiko H, Ariga T, Kikuta H. Detection of human bocavirus in Japanese children with lower respiratory tract infections. J Clin Microbiol. 2006;44(3):1132–4. doi: 10.1128/JCM.44.3.1132-1134.2006.
  17. Lee JI, Chung JY, Han TH, Song MO, Hwang ES. Detection of human bocavirus in children hospitalized because of acute gastroenteritis. J Infect Dis. 2007;196(7):994–7. doi: 10.1086/521366.
  18. Vicente D, Cilla G, Montes M, Pérez-Yarza EG, Pérez-Trallero E. Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis. 2007;13(4): 636–7. doi: 10.3201/eid1304.061501.
  19. Albuquerque MC, Rocha LN, Benati FJ, Soares CC, Maranhão AG, Ramírez ML, Erdman D, Santos N. Human bocavirus infection in children with gastroenteritis, Brazil. Emerg Infect Dis. 2007;13(11):1756–8. doi: 10.3201/eid1311.070671.
  20. Lau SK, Yip CC, Que TL, Lee RA, Au-Yeung RK, Zhou B, So LY, Lau YL, Chan KH, Woo PC, Yuen KY. Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J Infect Dis. 2007;196(7): 986–93. doi: 10.1086/521310.
  21. Chieochansin T, Thongmee C, Vimolket L, Theamboonlers A, Poovorawan Y. Human bocavirus infection in children with acute gastroenteritis and healthy controls. Jpn J Infect Dis. 2008;61(6):479–81.
  22. Yu JM, Li DD, Xu ZQ, Cheng WX, Zhang Q, Li HY, Cui SX, Miao-Jin, Yang SH, Fang ZY, Duan ZJ. Human bocavirus infection in children hospitalized with acute gastroenteritis in China. J Clin Virol. 2008;42(3):280–5. doi: 10.1016/j.jcv.2008.03.032.
  23. Cheng WX, Jin Y, Duan ZJ, Xu ZQ, Qi HM, Zhang Q, Yu JM, Zhu L, Jin M, Liu N, Cui SX, Li HY, Fang ZY. Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study. Clin Infect Dis. 2008;47(2):161–7. doi: 10.1086/589244.
  24. Campe H, Hartberger C, Sing A. Role of Human Bocavirus infections in outbreaks of gastroenteritis. J Clin Virol. 2008;43(3):340–2. doi: 10.1016/j.jcv.2008.07.014.
  25. Karalar L, Lindner J, Schimanski S, Kertai M, Segerer H, Modrow S. Prevalence and clinical aspects of human bocavirus infection in children. Clin Microbiol Infect. 2010;16(6):633–9. doi: 10.1111/j.1469-0691.2009.02889.x.
  26. Kantola K, Sadeghi M, Antikainen J, Kirveskari J, Delwart E, Hedman K, Söderlund-Venermo M. Real-time quantitative PCR detection of four human bocaviruses. J Clin Microbiol. 2010;48(11): 4044–50. doi: 10.1128/JCM.00686-10.
  27. Nadji SA, Poos-Ashkan L, Khalilzadeh S, Baghaie N, Shiraghaei MJ, Hassanzad M, Bolursaz MR. Phylogenetic analysis of human bocavirus isolated from children with acute respiratory illnesses and gastroenteritis in Iran. Scand J Infect Dis. 2010;42(8):598–603. doi: 10.3109/00365540903582442.
  28. Khamrin P, Malasao R, Chaimongkol N, Ukarapol N, Kongsricharoern T, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Circulating of human bocavirus 1, 2, 3, and 4 in pediatric patients with acute gastroenteritis in Thailand. Infect Genet Evol. 2012;12(3):565– 9. doi: 10.1016/j.meegid.2012.01.025. doi: 10.1016/j.meegid.2012.01.025.
  29. Tymentsev A, Tikunov A, Zhirakovskaia E, Kurilschikov A, Babkin I, Klemesheva V, Netesov S, Tikunova N. Human bocavirus in hospitalized children with acute gastroenteritis in Russia from 2010 to 2012. Infect Genet Evol. 2016;37:143–9. doi: 10.1016/j.meegid.2015.11.015.
  30. Jartti T, Söderlund-Venermo M, Allander T, Vuorinen T, Hedman K, Ruuskanen O. No efficacy of prednisolone in acute wheezing associated with human bocavirus infection. Pediatr Infect Dis J. 2011;30(6):521–3. doi: 10.1097/INF.0b013e318216dd81.
  31. Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, Alam MM, Sharif S, Angez M, Zaidi S, Delwart E. A newly identified bocavirus species in human stool. J Infect Dis. 2009;199(2):196–200. doi: 10.1086/595831.
  32. Kapoor A, Simmonds P, Slikas E, Li L, Bodhidatta L, Sethabutr O, Triki H, Bahri O, Oderinde BS, Baba MM, Bukbuk DN, Besser J, Bartkus J, Delwart E. Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections. J Infect Dis. 2010;201(11): 1633–43. doi: 10.1086/652416.
  33. Cotmore SF, Agbandje-McKenna M, Chiorini JA, Mukha DV, Pintel DJ, Qiu J, Soderlund-Venermo M, Tattersall P, Tijssen P, Gatherer D, Davison AJ. The family Parvoviridae. Arch. Virol. 2014;159(5):1239–47.
  34. Völz S, Schildgen O, Klinkenberg D, Ditt V, Müller A, Tillmann RL, Kupfer B, Bode U, Lentze MJ, Simon A. Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006. J Clin Virol. 2007;40(3):229–35. doi: 10.1016/j.jcv.2007.07.017.
  35. Böhmer A, Schildgen V, Lüsebrink J, Ziegler S, Tillmann RL, Kleines M, Schildgen O. Novel application for isothermal nucleic acid sequence-based amplification (NASBA). J Virol Methods. 2009;158(1–2):199–201. doi: 10.1016/j.jviromet.2009.02.010.
  36. Sun B, Cai Y, Li Y, Li J, Liu K, Li Y, Yang Y. The nonstructural protein NP1 of human bocavirus 1 induces cell cycle arrest and apoptosis in Hela cells. Virology. 2013;440(1):75–83. doi: 10.1016/j.virol.2013.02.013.
  37. Li L, Cotmore SF, Tattersall P. Parvoviral left-end hairpin ears are essential during infection for establishing a functional intranuclear transcription template and for efficient progeny genome encapsidation. J Virol. 2013;87(19):10501–14. doi: 10.1128/JVI.01393-13.
  38. Zhang Z, Zheng Z, Luo H, Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H. Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter. J Immunol. 2012;189(3): 1144–53. doi: 10.4049/jimmunol.1200096.
  39. Abdel-Latif L, Murray BK, Renberg RL, O'Neill KL, Porter H, Jensen JB, Johnson FB. Cell death in bovine parvovirus-infected embryonic bovine tracheal cells is mediated by necrosis rather than apoptosis. J Gen Virol. 2006;87(Pt 9):2539–48. doi: 10.1099/vir.0.81915-0.
  40. Babady NE, Mead P, Stiles J, Brennan C, Li H, Shuptar S, Stratton CW, Tang YW, Kamboj M. Comparison of the Luminex xTAG RVP Fast assay and the Idaho Technology FilmArray RP assay for detection of respiratory viruses in pediatric patients at a cancer hospital. J Clin Microbiol. 2012;50(7):2282–8. doi: 10.1128/JCM.06186-11.
  41. Lassaunière R, Kresfelder T, Venter M. A novel multiplex real-time RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses. J Virol Methods. 2010;165(2):254–60. doi: 10.1016/j.jviromet.2010.02.005.
  42. Hall GA. Comparative pathology of infection by novel diarrhoea viruses. Ciba Found Symp. 1987;128:192–217.
  43. Murphy FA, Gibbs EP, Horzinek MC, Studdert MJ. Veterinary virology. 3rd edition. San Diego: Academic Press; 1999. 629 р.
  44. Endo R, Ishiguro N, Kikuta H, Teramoto S, Shirkoohi R, Ma X, Ebihara T, Ishiko H, Ariga T. Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan. J Clin Microbiol. 2007;45(10): 3218–23. doi: 10.1128/JCM.02140-06.
  45. Kantola K, Hedman L, Allander T, Jartti T, Lehtinen P, Ruuskanen O, Hedman K, Söderlund-Venermo M. Serodiagnosis of human bocavirus infection. Clin Infect Dis. 2008;46(4):540–6. doi: 10.1086/526532.
  46. Schildgen O. Human bocavirus: lessons learned to date. Pathogens. 2013;2(1):1–12. doi: 10.3390/pathogens2010001.
  47. Hustedt JW, Christie C, Hustedt MM, Esposito D, Vazquez M. Seroepidemiology of human bocavirus infection in Jamaica. PLoS One. 2012;7(5):e38206. doi: 10.1371/journal.pone.0038206.
  48. Guo L, Wang Y, Zhou H, Wu C, Song J, Li J, Paranhos-Baccalà G, Vernet G, Wang J, Hung T. Differential seroprevalence of human bocavirus species 1–4 in Beijing, China. PLoS One. 2012;7(6):e39644. doi: 10.1371/journal.pone.0039644.
  49. Kantola K, Hedman L, Arthur J, Alibeto A, Delwart E, Jartti T, Ruuskanen O, Hedman K, Söderlund-Venermo M. Seroepidemiology of human bocaviruses 1–4. J Infect Dis. 2011;204(9):1403–12. doi: 10.1093/infdis/jir525.

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Copyright (c) 2017 Krasnova E.I., Tyumentsev A.I., Tikunova N.V., Khokhlova N.I., Provorova V.V.

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