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The new immunotherapeutic method is presented in the review - an extracorporeal photochemotherapy. The questions concerning its application in the T-cellular lymphoma of skin and transplantation of solid bodies are discussed. The special attention is paid to the mechanism of its therapeutic action.

About the authors

A. V. Kildyushevsky

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Author for correspondence.
Russian Federation

V. A. Fedulkina

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Russian Federation

O. A. Fomina

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Russian Federation

A. M. Fomin

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Russian Federation


  1. Кильдюшевский A.B., Молочков В.А., Карзанов О.В. Динамика клеточного иммунитета в процессе экстракорпоральной фотохимиотерапии у больных истинной пузырчаткой//Рос. журн. кожн. венерич. бол. 2008. N94. С.71-76.
  2. Молочков В.А., Кильдюшевский A.B., Молочков A.B. и др. Клинико-иммунологические аспекты экстракорпоральной фотохимиотерапии при псориазе и псориартрическом артрите//Тер. арх. 2012. N910. С.69-74.
  3. Федулнина В.А., Ватазин A.B., Кильдюшевсний A.B. и др. Трансляционная клеточная иммунотерапия при аллотрансплантации трупной почки у урологических больных//Альм. клин. мед. 2013. №28. С.25-31.
  4. Andreu G., Leon A., Heshmati F. et al. Extracorporeal photochemotherapy (ECP): evaluation of two techniques and use in connective tissues disorders//Transfus. Sei. 1994. V.15. P.443-454.
  5. Azuma H., Chandraker A., Nadeau K. et al. Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection//Proc. Nat. Acad. Sei. USA. 1996. V.93. P.12439-12444.
  6. Baron E.D., Heeger P.S., Hreecik D.E. et al. Immunomodulatory effect of extracorporeal photopheresis after successful treatment of resistant Renal allograft rejection//Photodermatol. Photoimmunol. Photomed. 2001. V.17. P.79-82.
  7. Barr M.L. et al. Photopheresis for the prevention of rejection in cardiac transplantation//N. Engl. J. Med. 1998. V.339. P.1744-1751.
  8. Berger C., Hoffmann K., Vasquez J.G. et al. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy//Blood. 2010. V.116. P.4838-4847.
  9. Berger C.L., Hanlon D., Kanada D. et al. Transimmunization, a novel approach for tumor immunotherapy//Transfus. Apher. Sei. 2002. V.26, No.3. P.205-216.
  10. Berthoux F.C., Jones E.H., Mehls О., Valderrabano F. Transplantation Report. 1: renal transplantation in recipients aged 60 years or older at time of grafting. The EDTAERA Registry. European Dialysis and Transplant Association-European Renal Association//Nephrol. Dial. Transplant. 1996. V.ll, Suppl. P.37.
  11. Brzezinska A., Magalska A., Szybinska A., Sikora E. Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging//Exp. Gerontol. 2004. P.539.
  12. Chandraker A., Russell M.E., Glysing-Jensen T. et al. T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: Effects of cyclosporine and donor antigen//Transplantation. 1997. V.63. P. 1053-1058.
  13. Chang-Qing X., Campbell K.A., Clare-Salzlera M.J. Extracorporeal photopheresis-induced immune tolerance: a focus on modulation of antigen-presenting cells and induction of regulatory T cells by apoptotic cells//Cur. Opin. Organ Transplant. 2009. V.14, No.4. P.338-343.
  14. Christie J.D., Edwards L.B., Kucheryavaya A.Y. et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report-2010//J. Heart Lung Transplant. 2010. V.29, No.10. P.1104-1118.
  15. Colombatti A., Doliana R., Schiappacassi M. et al. Age-related persistent clonal expansions of CD28(-) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences//Clin. Immunol. Immunopathol. 1998. V.89. P.61-68.
  16. Crovetti G., Carabelli A., Berti E. et al. Photopheresis in cutaneous T-cell lymphoma: a five-year experience//Int. J. Artif. Organs. 2000. V.23. P.55-62.
  17. Dall'Amico R., Murer L. Extracorporeal photochemotherapy: a new therapeutic approach for allograft rejection//Transfus. Apher. Sei. 2002. V.26. P.197-204.
  18. Di Renzo M., Rubegni P., De Aloe G. et al. Extracorporeal photochemotherapy restores Thl/Th2 imbalance in patients with early stage cutaneous T-cell lymphoma//Immunology. 1997. V.92, No.l. P.99-103.
  19. Durrbach A. Advances in immunosuppression for renal transplantation//Nat. Rev. Nephrol, 2010. V.6. P.160-167.
  20. Edelson R.L., Berger C.L., Gasparro F.P. et al. Treatment of leukemic cutaneous T-cell lymphoma with extracorporeally photoactivated 8-methoxypsoralen//N. Engl. J. Med. 1987. V.316. P.297-303.
  21. Estenne M., Maurer J.R., Boehler A. et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria//J. Heart Lung Transplant. 2002. V.21, No.3. P.297-310.
  22. Evans A.V., Wood B.P., Scarisbrick J.J. et al. Extracorporeal photopheresis in Sezary syndrome: hematologic parameters as predictor of response//Blood. 2001. V.98. P.1298-1301.
  23. Fenton S., Desmeules M., Copleston P. et al. Renal replacement therapy in Canada: a report from the Canadian Organ Replacement Register//Am. G. Kidney Dis. 1995. V.25. P.134.
  24. Ferguson R., Grinyó J., Vincenti F. et al, Immunosuppression with Belatacept-Based, Corticosteroid-Avoiding Regimens in De Novo Kidney Transplant Recipients//Am. J. Transplant. 2011. V.ll, No.l. P.66-76.
  25. Fimiani М., Rubegrii Р., Pimpinelli N. et al. Extracorporeal photochemotherapy induces a significant increase in CD36+ circulating monocytes in patients with mycosis fungoides//Dermatology. 1997, V.194, No.2. P.107-110.
  26. Francine M. New insights into the mechanism of action of extracorporeal phototherapy//Transfusion. 2006. V.46. P.6-8.
  27. Genberg H., Kumlien G., Shanwell A., Tyden G. Refractory acute renal allograft rejection successfully treated with photopheresis//Transplant. Proc. 2005. V.37. P.3288-3289.
  28. Gerber A., Bohne M., Rasch J. et al. Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis//Dermatology. 2000. V.201, No.2. P.lll-117.
  29. Girardi M., Berger C.L., Wilson L.D. et al. Transimmunization for cutaneous T cell lymphoma: a Phase I study//Leuk. Lymphoma. 2006. V.47, No.8. P.1495-1503.
  30. Heshmati F. Mechanisms of action of extracorporeal photochemotherapy//Transfus. Apher. Sei. 2003. V.29. P.61-70.
  31. Hsu H.C., Scott D.K., Zhang P. et al. CD8 T-cell immune phenotype of successful aging//Mech. Ageing Dev. 2006. P.127-231.
  32. Jagasia M.H., Savani B.N., Stricklin G. et al. Classic and overlap chronic graft-versus-host disease (cGVHD) is associated with superior outcome after extracorporeal photopheresis (ECP)//Biol. Blood Marrow Transplant. 2009. V.15, No.10. P.1288-1295.
  33. Kim K.S., Denton M.D., Chandraker A. et al. CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: Differential role of B7-1 in initiation versus progression of graft arteriosclerosis//Am. J. Pathol. 2001. V.158. P.977-986.
  34. Kirk A.D., Harlan D.M., Armstrong N.N. et al. CTLA4-lg and anti-CD40 ligand prevent renal allograft rejection in primates//Proc. Nat. Acad. Sei. USA. 1997. V.94. P.8789-8794.
  35. Knobler R., Barr M.L., Couriel D.R. et al. Extracorporeal photopheresis: past, present, and future//J. Am. Acad. Dermatol. 2009. V.61, No.4. P.652-665.
  36. Knobler R., Jantschitsch C. Extracorporeal photo-chemoimmunotherapy in cutaneous T-cell lymphoma//Transfus. Apher. Sei. 2003. V. 28. P.81-89.
  37. Treatment of systemic lupus erythematous, a pilot study//Arthrit. Rheum. 1992. V.35. P.319-323.
  38. Kumlien G., Genberg H., Shanwell A., Tydén G. Photopheresis for the treatment of refractory renal graft rejection//Transplantation. 2005. V.79, No.l. P.123-125.
  39. Kusztal M., Kosmaczewska A., Magott-Procelewska M. et al. CD28 down regulation on CD4+ T cells is associated with age of kidney transplant recipient//Transplantation. 2008. V.21, No.7. P.661-668.
  40. Lim H.W., Edelson R.L. Photopheresis for the treatment of cutaneous T-cell Lymphoma//Hematol. Oncol. Clin. North Am. 1995. V.9. P.1117-1124.
  41. Maeda A., Beissert S., Schwarz T., Schwarz A. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells//J. Immunol. 2008. V.180, No.5. P.3065-3071.
  42. Miller J.D., Kirkland E.B., Domingo D.S. et al. Review of extracorporeal photopheresis in early-stage (IA, IB, and IIA) cutaneous T-cell lymphoma//Photodermatol. Photoimmunol. Photomed. 2007. V.23, No.5. P.163-171.
  43. Pearson T., Alexander D., Hendrix R. et al. CTLA4-lg plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism//Transplantation. 1995. V.61. P.997-1004.
  44. Pearson T.C., Alexander D.Z., Winn K.J. et al. Transplantation tolerance induced by CTLA4-lg//Transplantation. 1994. V.57. P.1701-1706.
  45. Peritt D. Potential mechanisms of photopheresis in hematopoietic stem cell transplantation//Biol. Blood Marrow Trans-plant. 2006. V.12. P.7-12.
  46. Perseghin P., Dassi M., Balduzzi A. et al. Mononuclear cell collection in patients undergoing extracorporeal photochemotherapy for acute and chronic graft-vs-host disease (GvHD): comparison between СОВЕ Spectra version 4.7 and 6.0 (Auto PBSC)//J. Clin. Apher. 2002. V.17. P.65-71.
  47. Perseghin P., Galimberti S., Balduzzi A. et al. Extracorporeal photochemotherapy for the treatment of chronic graft-versus-host disease: trend for a possible cell dose-related effect?//Ther. Apher. Dial. 2007. V.U. P.85-93.
  48. Rook A.H., Freundlich В., Jegasothy B.V. et al. Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial//Arch. Dermatol. 1992. V.128, No.3. P.337-346.
  49. Russell M.E., Hancock W.W., Akalin E. et al. Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD 28:B7 costimulation by CTLA4lg modulates T cell and macrophage activation and attenuates arteriosclerosis//J. Clin. Invest. 1996. V.97. P.833-838.
  50. Salskov-Iversen M., Berger C.L., Edelson R.L. Rapid construction of a dendritic cell vaccine through physical perturbation and apoptotic malignant T cell loading//J. Im. Bas. Ther. Vac. 2005. V.10. P.1186-1476.
  51. Solvaneschi L., Perotti C., Zecca M. et al. Extracorporeal photochemotherapy for the treatment of acute and chronic GVHD in childhood//Transfusion. 2001.V.41. P.1299-1305.
  52. Sander-Plassman G., Druml W., Steininger R. et al. Renal allograft rejection controlled by photopheresis//Lancet. 1995. P.346-506.
  53. Sayegh M.H., Akalin £, Hancock W.W. et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Thl cytokines but spares Th2//J. Exp. Med. 1995. V.181. P.1869-1874.
  54. Scarisbrick J.J., Taylor P., Holtick U. et al. U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease//Br. J. Dermatol. 2008. V.158, No.4. P.659-678.
  55. Schooneman F. Extracorporeal photopheresis technical aspects//Transfus. Apher. Sei. 2003. V.28. P.51-61.
  56. Slovis B.S., Loyd I.Е., King L.E. Photopheresis for chronic rejection of lung allografts//N. Engl. J. Med. 1995. V.332, No.14. P.962-968.
  57. Stadler R., Assaf C., Klemke C. et al. S2k Kurzleitlinie Kutane Lymphome. AWMF, 2012.
  58. Talpur R., Demierre M.F., Geskin L. et al. Multicenter photopheresis intervention trial in early-stage mycosis fungoides//Clin. Lymph. Myel. Leuk. 2011. V.ll, No.2. P.219-227.
  59. Trautinger F., Knobler R., WilIemze R. et al. EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome//Eur. J. Cancer. 2006. V.42, No.8. P.1014-1030.
  60. US National Institutes of Health NCI. Mycosis fungoides and the Sezary syndrome treatment (PDQ). Available at: pages.
  61. Warrington K.J., Vallejo A.N., Weyand C.M., Goronzy J.L. CD28 loss in senescent CD4+ T cells: reversal by inter-leukin-12 stimulation//Blood. 2003. V.101. P.3543.

Copyright (c) 2014 Kildyushevsky A.V., Fedulkina V.A., Fomina O.A., Fomin A.M.

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