Email this article POLYMORPHISM OF CLINICAL MANIFESTATIONS OF CRYOGLOBULINEMIA-RELATED VASCULITIS ASSOCIATED WITH CHRONIC HEPATITIS С VIRUS INFECTION
- Authors: Milovanova S.Y.1, Kozlovskaya L.V.1, Gordovskaya N.B.1
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University
- Issue: No 30 (2014)
- Pages: 46-51
- Section: ACTUAL PROBLEMS OF NEPHROLOGY
- URL: https://almclinmed.ru/jour/article/view/288
- DOI: https://doi.org/10.18786/2072-0505-2014-30-46-51
- ID: 288
Cite item
Full Text
Abstract
The authors investigated the clinical picture characteristics and prognostic value of HCV-associated cryoglobulinemic vasculitis variations. More rapid fibrosis formation was shown in chronic hepatitis С patients with CG as compared with those without CG which allows considering CG the marker of the chronic hepatitis C. It was found that the frequency and severity of some extrahepatic lesions and immunological changes in patients with CG were expressed more greatly than those in patients without CG, and these data were statistically significant. The results obtained confirm the role of cryoglobulinemic vasculitis as an important mechanism for development of systemic lesions in hepatitis-C. The importance of CG as a predictor of the malignant В-cell lymphoproliferation in patients with chronic hepatitis С was proved.
About the authors
S. Yu. Milovanova
I.M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: fake@neicon.ru
Россия
L. V. Kozlovskaya
I.M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Россия
N. B. Gordovskaya
I.M. Sechenov First Moscow State Medical University
Email: fake@neicon.ru
Россия
References
- Милованова C.Ю., Козловская Л.В. Криоглобулинемия, ассоциированная с инфекцией, обусловленной гепатитом С. Возможности и ограничения противовирусной терапии//Качество жизни. Болезни почек. 2006. N94. С.25-30.
- Милованова С.Ю., Козловская Л.В. Современные возможности лечения HCV-ассоциированного криоглобулинемического васкулита//Гепатол. форум. 2011. N93. С.11-13.
- Милованова С.Ю., Козловская Л.В., Гордовская Н.Б. HCV-ассоциированный криоглобулинемический васкулит с тяжелым поражением почек и развитием В-клеточной лимфомы. Современные возможности изменения прогноза с помощью моноклональных антител к CD 20 и противовирусной терапии//Клин. нефрол. 2011. N92. С.61-69.
- Agnello V. Hepatitis С virus infection and II type cryoglobulinemia; an immunological perspective//Hepatolo-gy. 1997. V.26. P.1375-1379.
- Cacoub P., Renou C., Rosenthal E. et al. Extrahepatic manifestations associated with hepatitis С virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d'Etude et de Recherché en Medicine Interne et Maldies Infectieuses sur le Virus de l'Hepatite С//Medicine. 2000. V.79. P.47-56.
- Dammacco F. HCV infection and cryoglobulinemia. London -Milan: Springer, 2012. 360 p.
- Ferri C. Mixed cryoglobulins (review)//Orphanet J. Rare Dis. 2008. V.3. P.25.
- Ferri C., La Civita L., Longombardo G. et al. Hepatitis С virus and mixed cryoglobulinemia (review)//Eur. J. Clin. Invest. 1993. V.23. P.399-405.
- Kayali Z., Buckwold V.E., Zimmerman B. Hepatitis С, cryoglobulinemia and cirrhosis: a meta analysis//Hepa-tology. 2002. V.36. P.978-985.
- Lunel F., Musset L., Cacoub P. et al. Cryoglobulinemia in chronic liver disease: role of hepatitis С virus damage//Gastroenterology. 1994. V.106. P.1291-1300.
- Pellicano R., Leone N., Maiocco I.A., Modena V. et al. Chronic HCV hepatopathy and cryoglobulinemia. The as-sociated clinical spectrum 11 Minerva Med. 1999. V.90. P. 1-5.
- Siagris D., Christofidou M., Lekkou A. et al. Cryoglobulinemia and progression of fibrosis in chronic HCV infec-tion cause or effect?//J. Infect. 2004. V.49. P.236-241.
Supplementary files
