Email this article THE CAUSES AND THE COURSE OF CHRONIC KIDNEY DISEASE IN CHILDREN OF PRESCHOOL AGE
- Authors: Abaseeva T.Y.1, Pankratenko T.E.1, Burov A.A.1, Emirova K.M.2, Muzurov A.L.3
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Affiliations:
- Moscow Regional Research and Clinical Institute
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- Russian Medical Academy of Postgraduate Education, Moscow
- Issue: No 42 (2015)
- Pages: 58-65
- Section: ARTICLES
- URL: https://almclinmed.ru/jour/article/view/21
- DOI: https://doi.org/10.18786/2072-0505-2015-42-58-65
- ID: 21
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Abstract
Background: Data on etiology and clinical course of CKD stage 3 to 5 in children of preschool age could help obstetricians, pediatricians, and nephrologists with proper diagnostics and management of this condition and prediction of outcomes. Aim: To study causes and clinical features of CKD stage 3 to 5 in preschool children. Materials and methods: The causes and clinical features of CKD stage 3 to 5 were investigated in 55 preschool children aged from 7 months to 8 years. Twenty four had CKD stage 3 to 4 and 31 children with endstage CKD were on peritoneal dialysis. Results:96% of CKD stage 3 to 5 in preschool children were due to congenital/genetic kidney abnormalities. Predictors of renal replacement therapy beginning in the first 5 years of life were as follows: antenatal detection of congenital abnormalities of the kidney and urinary tract, oligohydroamnion, high neonatal BUN levels. Anemia, hyperparathyroidism, arterial hypertension were more prevalent in children on the dialysis stage of CKD, and myocardial hypertrophy and/or of the left ventricle dilatation were found in 26% of them. Forty two percent of children had growth retardation, and 40% had delayed speech development. Conclusion: The course CKD in preschool children is characterized by a combination of typical metabolic disorders with the growth retardation (often dramatic) and delayed mental development that significantly limits the possibilities of the social adaptation of these children and social activities of their parents. Participation of neuropsychiatrists, clinical psychologists, and teachers, rather than pediatricians and nephrologists only, is desirable in management of preschool children with CKD stage 3 to 5.
About the authors
T. Yu. Abaseeva
Moscow Regional Research and Clinical Institute
Author for correspondence.
Email: tatiana2103@inbox.ru
Abaseeva Tat'yana Yu. – PhD, Senior Research Fellow, Department of Pediatric Dialysis and Hemocorrection Россия
T. E. Pankratenko
Moscow Regional Research and Clinical Institute
Email: tatiana2103@inbox.ru
Pankratenko Tat'yana E. – PhD, Head of Department of Pediatric Dialysis and Hemocorrection Россия
A. A. Burov
Moscow Regional Research and Clinical Institute
Email: tatiana2103@inbox.ru
Burov Aleksandr A. – Research Fellow, Department of Pediatric Dialysis and Hemocorrection Россия
Kh. M. Emirova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: tatiana2103@inbox.ru
Emirova Khadizha M. – PhD, Associate Professor, Chair of Pediatrics Россия
A. L. Muzurov
Russian Medical Academy of Postgraduate Education, Moscow
Email: tatiana2103@inbox.ru
Muzurov Aleksandr L. – PhD, Assistant Professor, Chair of Pediatric Anesthesiology, Resuscitation and Toxicology Россия
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