Email this article EXTRA-CORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF LYMPHOMATOID PAPULOSIS AND FOLLICULOTROPIC MYCOSIS FUNGOIDES: CASE REPORTS
- Authors: Kil’dyushevskiy A.V.1,2, Karzanov O.V.1,2, Aleksandrovа N.M.1,2
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
- Issue: No 34 (2014)
- Pages: 81-84
- Section: DERMATO-ONCOLOGY
- URL: https://almclinmed.ru/jour/article/view/194
- DOI: https://doi.org/10.18786/2072-0505-2014-34-81-84
- ID: 194
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Abstract
Aim: To assess clinical efficacy of extra-corporeal photochemotherapy (EPCT) in the treatment of rare lymphomas – lymphomatoid papulosis and folliculotropic mycosis fungoides. Materials and methods: This is a presentation of two cases of lymphomatoid papulosis and folliculotropic mycosis fungoides treated with EPCT with duration of follow-up 9 and 12 years. Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UVA-radiation (λ=320–400 nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: Both patients demonstrated positive effect involving regression of the rashes after 3 EPCT cycles. Subsequently, the patients received maintenance EPCT 2–3 times a year. Conclusion: High clinical efficacy of EPCT was demonstrated in 2 patients with lymphomatoid papulosis and folliculotropic mycosis fungoides after 9 and 12 years of follow-up.
About the authors
A. V. Kil’dyushevskiy
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: fake@neicon.ru
MD, PhD, Professor, Leading Research Associate, Surgical Hemocorrection and Detoxication Department Россия
O. V. Karzanov
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Author for correspondence.
Email: dr_karzanov@mail.ru
PhD, Senior Research Associate, Dermatovenereology and Dermato-Oncology Department Россия
N. M. Aleksandrovа
Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation
Email: fake@neicon.ru
MD, PhD, Associate Professor, Dermatovenereology and Dermato-Oncology Department Россия
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