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The article presents most recent data on antibiotic-associated intestinal disorders. The author reviews epidemiology and causative microorganisms in antibiotic-induced diarrhea and pseudomembranous colitis as well as clinical variants of antibiotic-associated disorders. Diagnosis methods are decribed at length with special attention to most sensitive and informative tests. Treatment of different clinical variants of antibiotic-induced disorders is discussed in detail.

About the authors

E. A. Belousova

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., Moscow, 129110, Russian Federation

Author for correspondence.

MD, PhD, Professor, Head of the Department of Gastroenterology and Hepatology, Head of the Chair of Gastroenterology, the Faculty of Postgraduate Medical Education, MONIKI; Principal Gastroenterologist of the Moscow Region

Russian Federation


  1. Шевяков МА. Антибиотикассоциированная диарея и кандидоз кишечника: возможности лечения и профилактики. Антибиотики и химиотерапия. 2004;49(10):26-9. (Shevyakov MA. [Antibiotic-associated diarrhea and intestinal candidiasis: treatment and prevention]. Antibiotiki i khimioterapiya. 2004;49(10):26-9. Russian).
  2. Циммерман ЯС. Дисбиоз («дисбактериоз») кишечника и его клинические манифестные формы: антибиотикассоциированная диарея и псевдомембранозный колит. Пермь; 2005. (Tsimmerman YaS. Intestinal disbiosis and forms of its clinical manifestation: antibiotic-associated diarrhea and pseudomembranous colitis. Perm’; 2005. Russian).
  3. Rambaud JC, ButsJP, Corthier G, Flourie B, editors. Gut microflora. Digestive physiology and pathology. Paris: John Libbey Eurotext; 2006.
  4. Муконин АА, Гайдуль КВ. Антибиотикассоциированная диарея и псевдомембранозный колит как осложнения антибактериальной терапии. М.; 2004. Available from: http://www. (Mukonin AA, Gaydul’ KV. Antibiotic-associated diarrhea and pseudomembranous colitis: complications of antibiotic therapy. Moscow; 2004. Available from: http://www.abolmed. ru. Russian).
  5. Парфенов АИ. Энтерология. М.: Триада-X; 2002. (Parfenov AI. Enterology. Moscow: Triada-X; 2002. Russian).
  6. Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 1997;92(5):739-50.
  7. Kelly CP, Pothoulakis C, LaMont JT. Clostridium difficile colitis. N Engl J Med. 1994;330(4):257-62.
  8. Benoit R, Dorval D, Loulergue J, Bacq Y, Oliver JM, Audurier A, Metman EH. Post-antibiotic diarrheas: role of Klebsiella oxytoca. Gastroenterol Clin Biol. 1992;16(11):860-4.
  9. Белоусова ЕА. Дисбактериоз кишечника. B: Рапопорт СИ, Комаров ФИ, ред. Руководство по гастроэнтерологии. М.: ГЭОТАР-Медиа; 2010. (Belousova EA. Intestinal disbiosis. In: Rapoport SI, Komarov FI, editors. Manual of Gastroenterology. Moscow: GEOTAR-Media; 2010. Russian).
  10. Voth DE, Ballard JD. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev. 2005;18(2):247-63.
  11. Осипенко МФ, Бикбулатова ЕА. Антибиотикассоциированная диарея, подходы к диагностике и лечению. Фарматека. 2007;(13):89-93. (Osipenko MF, Bikbulatova EA. [Antibioticassociated diarrhea, approaches to diagnosis and treatment]. Farmateka. 2007;(13):89-93. Russian).
  12. Ananthakrishnan AN. Detecting and treating Clostridium difficile infections in patients with inflammatory bowel disease. Gastroenterol Clin North Am. 2012;41(2):339-53.
  13. Vanpoucke H, De Baere T, Claeys G, Vaneechoutte M, Verschraegen G. Evaluation of six commercial assays for the rapid detection of Clostridium difficile toxin and/or antigen in stool specimens. Clin Microbiol Infect. 2001;7(2):55-64.
  14. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5):431-55.
  15. Scarpignato C, editor. Rifaximin: a poorly absorbed antibiotic. Pharmacology and clinical use. Basel: Karger; 2005.
  16. Белоусова ЕА. Sассharomyces boulardii (Энтерол) в гастроэнтерологической практике: обзор литературы. Фарматека. 2006;(12):41-5. (Belousova EA. [Sассharomyces boulardii (Enterol) in the practice of gastroenterologist: a review]. Farmateka. 2006;(12):41-5. Russian).
  17. Surawicz CM, McFarland LV, Greenberg RN, Rubin M, Fekety R, Mulligan ME, Garcia RJ, Brandmarker S, Bowen K, Borjal D, Elmer GW. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis. 2000;31(4):1012-7.
  18. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA. 1994;271(24):1913-8.
  19. Alander M, Satokari R, Korpela R, Saxelin M, Vilpponen-Salmela T, Mattila-Sandholm T, von Wright A. Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol. 1999;65(1):351-4.
  20. Johansson ML, Molin G, Jeppsson B, Nobaek S, Ahrné S, Bengmark S. Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora. Appl Environ Microbiol. 1993;59(1):15-20.

Copyright (c) 2014 Belousova E.A.

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