Expression of the immune checkpoint B7-H3 in tumor and its soluble form in serum of patients with bone neoplasms

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Abstract

B7-H3, also called CD276, is a type I transmembrane glycoprotein that is encoded on human chromosome 15. It was discovered back in 2001. The original study described it as a positive co-stimulant, as it can stimulate T-cell response and IFN-y production. However, recent researches have shown that B7-H3 is involved in T-cell inhibition. A B7-H3 receptor has not been yet identified, and this may explain the complex immunomodulatory activity of B7-H3, as it can have more than one binding partner with different functions. Expression of the B7-H3 protein has been found on activated immune cells such as T-cells, NK cells and antigen presenting cells. Interestingly, it is overexpressed in a wide range of tumor cells and is associated with disease progression and outcome. The soluble form of this protein is also of particular interest. Increased sB7-H3 levels in the plasma of bone tumor patients might be their important diagnostic criterion.

About the authors

N. E. Kushlinskii

N.N. Blokhin National Medical Research Center of Oncology

Author for correspondence.
Email: biochimia@yandex.ru
ORCID iD: 0000-0002-3898-4127

Nikolay E. Kushlinskii - MD, PhD, Professor, Member of Russian Academy of Sciences, Head of Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Tel.: +7 (499) 324 11 59.

Russian Federation

O. V. Kovaleva

N.N. Blokhin National Medical Research Center of Oncology

Email: fake@neicon.ru
ORCID iD: 0000-0001-6132-9924

Olga V. Kovaleva - PhD (in Biol.), Senior Research Fellow, Laboratory of Regulation of Cellular and Viral Oncogenes, Research Institute of Carcinogenesis.

24 Kashirskoe shosse, Moscow, 115478.

Russian Federation

A. A. Alferov

N.N. Blokhin National Medical Research Center of Oncology

Email: fake@neicon.ru
ORCID iD: 0000-0003-3585-5693

Aleksandr A. Alferov - Clinical Pathologist, Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Russian Federation

Yu. B. Kuzmin

N.N. Blokhin National Medical Research Center of Oncology

Email: fake@neicon.ru
ORCID iD: 0000-0001-9684-2509

Yurii B. Kuzmin - Research Laboratory Assistant, Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Russian Federation

E. A. Sushentsov

N.N. Blokhin National Medical Research Center of Oncology

Email: fake@neicon.ru
ORCID iD: 0000-0003-3672-1742

Evgeny A. Sushentsov - MD, PhD, Head of Department of Surgical Treatment Methods No. 14 (Oncoorthopedics).

24 Kashirskoe shosse, Moscow, 115478.

Russian Federation

I. S. Stilidi

N.N. Blokhin National Medical Research Center of Oncology

Email: fake@neicon.ru
ORCID iD: 0000-0002-0493-1166

Ivan S. Stilidi - MD, PhD, Professor, Member of the Russian Academy of Sciences, Director.

24 Kashirskoe shosse, Moscow, 115478.

Russian Federation

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