Contrast-enhanced magnetic resonance imaging in the diagnosis of Meniere’s disease: vague future or tangible reality?

Cover Page


Cite item

Full Text

Abstract

Meniere's disease is characterized by vertigo, inconsistent hearing loss and progressive deterioration of audiological and vestibular functions. The attacks of Meniere's disease occur without obvious triggers and disrupt social adaptation of patients. Radiation diagnostic methods have not been included into the list of diagnostic criteria by the European Consensus on Diagnosis and Management of Meniere's disease (2018). However, a  number of studies have been published recently that indicate the feasibility of in vivo anatomical identification of endolymphatic hydrops, as the main disease substrate seen using contrast-enhanced magnetic resonance imaging. Due to the progress in radiological visualization of the inner ear, some patterns have been identified and new data obtained for Meniere's disease. The choice of the best route for contrast administration (intratympanic or intravenous) is a matter of active debate. There is no consensus on the criteria for the assessment of hydrops' grade. Future developments of the technique are associated with improvements of diagnostic procedures and protocols, use of new contrast agents and diagnostic algorithms developed with consideration of the otological problem of patients.

About the authors

E. A. Stepanova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: stepanovamoniki@gmail.com
ORCID iD: 0000-0002-9037-0034

Elena A. Stepanova – MD, PhD, Chief Research Fellow, Diagnostic Department 

61/2 Shchepkina ul., Moscow, 129110

Россия

References

  1. Gürkov R, Flatz W, Louza J, Strupp M, Ertl-Wagner B, Krause E. In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Ménière's disease. Otol Neurotol. 2012;33(6):1040–1045. doi: 10.1097/MAO.0b013e31825d9a95.
  2. Wright T. Menière's disease. BMJ Clin Evid. 2015;2015:0505.
  3. Nakashima T, Pyykkö I, Arroll MA, Casselbrant ML, Foster CA, Manzoor NF, Megerian CA, Naganawa S, Young YH. Meniere's disease. Nat Rev Dis Primers. 2016;2:16028. doi: 10.1038/nrdp.2016.28.
  4. Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M. European Position Statement on Diagnosis, and Treatment of Meniere's Disease. J Int Adv Otol. 2018;14(2): 317–321. doi: 10.5152/iao.2018.140818.
  5. Nakashima T, Naganawa S, Sugiura M, Teranishi M, Sone M, Hayashi H, Nakata S, Katayama N, Ishida IM. Visualization of endolymphatic hydrops in patients with Meniere's disease. Laryngoscope. 2007;117(3):415–420. doi: 10.1097/MLG.0b013e31802c300c.
  6. Naganawa S, Yamazaki M, Kawai H, Bokura K, Iida T, Sone M, Nakashima T. MR imaging of Ménière's disease after combined intratympanic and intravenous injection of gadolinium using HYDROPS2. Magn Reson Med Sci. 2014;13(2):133–137. doi: 10.2463/mrms.2013-0061.
  7. Pyykkö I, Zou J, Gürkov R, Naganawa S, Nakashima T. Imaging of Temporal Bone. Adv Otorhinolaryngol. 2019;82:12–31. doi: 10.1159/000490268.
  8. Zou J, Pyykkö I, Bjelke B, Dastidar P, Toppila E. Communication between the perilymphatic scalae and spiral ligament visualized by in vivo MRI. Audiol Neurootol. 2005;10(3):145–152. doi: 10.1159/000084024.
  9. Naganawa S, Kawai H, Ikeda M, Sone M, Nakashima T. Imaging of endolymphatic hydrops in 10 minutes: a new strategy to reduce scan time to one third. Magn Reson Med Sci. 2015;14(1):77–83. doi: 10.2463/mrms.2014-0065.
  10. Naganawa S, Nakashima T. Visualization of endolymphatic hydrops with MR imaging in patients with Ménière's disease and related pathologies: current status of its methods and clinical significance. Jpn J Radiol. 2014;32(4): 191–204. doi: 10.1007/s11604-014-0290-4.
  11. Степанова ЕА, Вишнякова МВ, Крюков АИ, Кунельская НЛ, Свистушкин ВМ, Биданова ДБ, Янюшкина ЕС, Абраменко АС. Опыт применения МРТ в диагностике болезни Меньера. Российский электронный журнал лучевой диагностики. 2019;9(3):18–23. doi: 10.21569/2222-7415-2019-9-3-18-23.
  12. Naganawa S, Yamazaki M, Kawai H, Sone M, Nakashima T. Contrast enhancement of the anterior eye segment and subarachnoid space: detection in the normal state by heavily T2-weighted 3D FLAIR. Magn Reson Med Sci. 2011;10(3):193–199. doi: 10.2463/mrms.10.193.
  13. Zou J, Pyykkö I. Enhanced oval window and blocked round window passages for middle-inner ear transportation of gadolinium in guinea pigs with a perforated round window membrane. Eur Arch Otorhinolaryngol. 2015;272(2):303–309. doi: 10.1007/s00405-013-2856-7.
  14. Louza J, Krause E, Gürkov R. Hearing function after intratympanic application of gadolinium-based contrast agent: A long-term evaluation. Laryngoscope. 2015;125(10):2366–2370. doi: 10.1002/lary.25259.
  15. Wu Q, Dai C, Zhao M, Sha Y. The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope. 2016;126(4):974–979. doi: 10.1002/lary.25576.
  16. Yamazaki M, Naganawa S, Tagaya M, Kawai H, Ikeda M, Sone M, Teranishi M, Suzuki H, Nakashima T. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection. AJNR Am J Neuroradiol. 2012;33(4):773–778. doi: 10.3174/ajnr.A2821.
  17. Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T. Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time. Magn Reson Med Sci. 2012;11(3):213–219. doi: 10.2463/mrms.11.213.
  18. Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T. Imaging of Ménière's disease by subtraction of MR cisternography from positive perilymph image. Magn Reson Med Sci. 2012;11(4):303–309. doi: 10.2463/mrms.11.303.
  19. Sepahdari AR, Ishiyama G, Vorasubin N, Peng KA, Linetsky M, Ishiyama A. Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing. Clin Imaging. 2015;39(1):26–31. doi: 10.1016/j.clinimag.2014.09.014.
  20. Conte G, Lo Russo FM, Calloni SF, Sina C, Barozzi S, Di Berardino F, Scola E, Palumbo G, Zanetti D, Triulzi FM. MR imaging of endolymphatic hydrops in Ménière's disease: not all that glitters is gold. Acta Otorhinolaryngol Ital. 2018;38(4):369–376. doi: 10.14639/0392-100X1986.
  21. Nakashima T, Naganawa S, Pyykko I, Gibson WP, Sone M, Nakata S, Teranishi M. Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol Suppl. 2009;(560):5–8. doi: 10.1080/00016480902729827.
  22. Attyé A, Eliezer M, Boudiaf N, Tropres I, Chechin D, Schmerber S, Dumas G, Krainik A. MRI of endolymphatic hydrops in patients with Meniere's disease: a case-controlled study with a simplified classification based on saccular morphology. Eur Radiol. 2017;27(8): 3138–3146. doi: 10.1007/s00330-016-4701-z.
  23. Pakdaman MN, Ishiyama G, Ishiyama A, Peng KA, Kim HJ, Pope WB, Sepahdari AR. Blood-Labyrinth Barrier Permeability in Menière Disease and Idiopathic Sudden Sensorineural Hearing Loss: Findings on Delayed Postcontrast 3D-FLAIR MRI. AJNR Am J Neuroradiol. 2016;37(10):1903–1908. doi: 10.3174/ajnr.A4822.
  24. Pyykkö I, Nakashima T, Yoshida T, Zou J, Naganawa S. Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops. BMJ Open. 2013;3(2):e001555. doi: 10.1136/bmjopen-2012-001555.
  25. Pyykkö I, Zou J, Poe D, Nakashima T, Naganawa S. Magnetic resonance imaging of the inner ear in Meniere's disease. Otolaryngol Clin North Am. 2010;43(5):1059–1080. doi: 10.1016/j.otc.2010.06.001.
  26. Baráth K, Schuknecht B, Naldi AM, Schrepfer T, Bockisch CJ, Hegemann SC. Detection and grading of endolymphatic hydrops in Menière disease using MR imaging. AJNR Am J Neuroradiol. 2014;35(7):1387–1392. doi: 10.3174/ajnr.A3856.
  27. Gürkov R. Menière and Friends: Imaging and Classification of Hydropic Ear Disease. Otol Neurotol. 2017;38(10):e539–e544. doi: 10.1097/MAO.0000000000001479.
  28. Свистушкин ВМ, Морозова СВ, Варосян ЕГ, Степанова ЕА, Мухамедов ИТ, Биданова ДБ. Диагностическое значение магнитно-резонансной томографии височных костей при болезни Меньера: клинический случай. Consilium Medicum. 2019;21(11):63–66. doi: 10.26442/20751753.2019.11.190642.
  29. Крюков АИ, Кунельская НЛ, Гаров ЕВ, Степанова ЕА, Байбакова ЕВ, Янюшкина ЕС, Абраменко АС; ГБУЗ г. Москвы «Научно-исследовательский клинический институт оториноларингологии им. Л.И. Свержевского» ДЗ г. Москвы, патентообладатель. Способ определения степени эндолимфатического гидропса при болезни Меньера, выбор тактики лечения и оценка ее эффективности. Пат. 2630129 C1 Рос. Федерация. Опубл. 05.09.2017. 5.
  30. Gürkov R, Berman A, Dietrich O, Flatz W, Jerin C, Krause E, Keeser D, Ertl-Wagner B. MR volumetric assessment of endolymphatic hydrops. Eur Radiol. 2015;25(2):585–595. doi: 10.1007/s00330-014-3414-4.
  31. Naganawa S. The Technical and Clinical Features of 3D-FLAIR in Neuroimaging. Magn Reson Med Sci. 2015;14(2):93–106. doi: 10.2463/mrms.2014-0132.
  32. Cho YS, Ahn JM, Choi JE, Park HW, Kim YK, Kim HJ, Chung WH. Usefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Ménière's Disease. Sci Rep. 2018;8(1):17562. doi: 10.1038/s41598-018-35709-5.
  33. Shi S, Guo P, Wang W. Magnetic Resonance Imaging of Ménière's Disease After Intravenous Administration of Gadolinium. Ann Otol Rhinol Laryngol. 2018;127(11):777–782. doi: 10.1177/0003489418794699.
  34. Huang CH, Young YH. Bilateral Meniere's disease assessed by an inner ear test battery. Acta Otolaryngol. 2015;135(3):233–238. doi: 10.3109/00016489.2014.962184.
  35. Suga K, Kato M, Yoshida T, Nishio N, Nakada T, Sugiura S, Otake H, Kato K, Teranishi M, Sone M, Naganawa S, Nakashima T. Changes in endolymphatic hydrops in patients with Ménière's disease treated conservatively for more than 1 year. Acta Otolaryngol. 2015;135(9):866– 870. doi: 10.3109/00016489.2015.1015607.
  36. Maxwell R, Jerin C, Gürkov R. Utilisation of multi-frequency VEMPs improves diagnostic accuracy for Meniere's disease. Eur Arch Otorhinolaryngol. 2017;274(1):85–93. doi: 10.1007/s00405-016-4206-z.
  37. Jerin C, Maxwell R, Gürkov R. High-Frequency Horizontal Semicircular Canal Function in Certain Menière's Disease. Ear Hear. 2019;40(1):128–134. doi: 10.1097/AUD.0000000000000600.
  38. Gürkov R, Pyykö I, Zou J, Kentala E. What is Menière's disease? A contemporary re-evaluation of endolymphatic hydrops. J Neurol. 2016;263 Suppl 1:S71–S81. doi: 10.1007/s00415-015-7930-1.
  39. Zou J, Pyykkö I. Calcium Metabolism Profile in Rat Inner Ear Indicated by MRI After Tympanic Medial Wall Administration of Manganese Chloride. Ann Otol Rhinol Laryngol. 2016;125(1):53–62. doi: 10.1177/0003489415597916.
  40. Zou J, Ostrovsky S, Israel LL, Feng H, Kettunen MI, Lellouche JM, Pyykkö I. Efficient penetration of ceric ammonium nitrate oxidant-stabilized gamma-maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI. J Biomed Mater Res B Appl Biomater. 2017;105(7): 1883–1891. doi: 10.1002/jbm.b.33719.
  41. Pyykkö I, Zou J, Schrott-Fischer A, Glueckert R, Kinnunen P. An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders. Methods Mol Biol. 2016;1427:363–415. doi: 10.1007/978-1-4939-3615-1_21.
  42. Zou J, Peng B, Ostrovsky S, Li B, Li C, Kettunen MI, Lellouche JP, Pyykkö I. Biological effect tetra-branched anti-TNF-peptide and coating ratio-dependent penetration of the peptide-conjugated cerium3/4+ cation-stabilized gamma-maghemite nanoparticles into rat inner ear after transtympanic injection visualized by MRI. J Mater Sci Nanotechnol. 2017;5(2) [Internet]. Available from: http://www.annexpublishers.com/articles/JMSN/5204-Biological-Effect-Tetra-Branched-Anti-TNF-Peptide-and-Coating-Ratio-Dependent-Penetration-of-the-Peptide.pdf.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Stepanova E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies