Email this article The eye status in patients after new coronavirus infection
- Authors: Ryabtseva A.A.1, Grishina E.E.1, Andryukhina O.M.1, Kovrizhkina A.A.1, Andryukhina A.S.1
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Affiliations:
- Moscow Regional Research and Clinical Institute (MONIKI)
- Issue: Vol 48 (2020): Supplement 1
- Pages: 20-26
- Section: Journal Articles
- URL: https://almclinmed.ru/jour/article/view/1331
- DOI: https://doi.org/10.18786/2072-0505-2020-48-032
- ID: 1331
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Abstract
Rationale: The emerging new coronavirus infection caused by SARS-CoV-2 has resulted in a pandemic. Its clinical manifestations are highly variable and the death rate is high due to rapid progression to acute respiratory distress syndrome. Identified abnormalities of the eye are mainly related to conjunctival injury during manifestation of the disease.
Aim: To study the eye abnormalities in patients who have undergone COVID-19.
Materials and methods: Ophthalmological examination was performed in 23 patients (6 [26%] men and 17 [74%] women, median age 42.39 years) at days 44 to 85 after manifestation of COVID-19 infection in the Department of Ophthalmology, MONIKI. In addition to the standard ophthalmological examination, all patients were evaluated with optical coherence tomography (OCT), auto fluorescence, contrast and color sensitivity test with different light sources, and tear production assessment.
Results: In the late convalescence period there were complaints of dry eyes and abnormal color perception, with visual acuity being unchanged. The OCT assessment the peripapillary retina identified small hyper-reflective foci in the inner layers.
Conclusion: Eye disease in patients after COVID-19 is mainly related to the condition of the eye surface, abnormal color perception and abnormal architectonics of the inner retinal layers, which can persist for a long time during convalescence.
About the authors
A. A. Ryabtseva
Moscow Regional Research and Clinical Institute (MONIKI)
Author for correspondence.
Email: ryabtseva1953@mail.ru
ORCID iD: 0000-0002-1104-4047
Alla A. Ryabtseva - MD, PhD, Professor, Head of Department of Ophthalmology.
61/2-9 Shchepkina ul., Moscow, 129110, Tel.: +7 (925) 508 74 96
РоссияE. E. Grishina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
ORCID iD: 0000-0003-2668-9136
Elena E. Grishina - MD, PhD, Professor, Chief Research Fellow, Department of Oncology.
61/2 Shchepkina ul., Moscow, 129110
РоссияO. M. Andryukhina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Olga M. Andryukhina - Senior Research Fellow, Department of Ophthalmology.
61/2 Shchepkina ul., Moscow, 129110
РоссияA. A. Kovrizhkina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
ORCID iD: 0000-0002-5952-2183
Alina A. Kovrizhkina - Research Fellow, Department of Ophthalmology.
61/2 Shchepkina ul., Moscow, 129110
РоссияA. S. Andryukhina
Moscow Regional Research and Clinical Institute (MONIKI)
Email: fake@neicon.ru
Anna S. Andryukhina - Junior Research Fellow, Department of Ophthalmology.
61/2 Shchepkina ul., Moscow, 129110
РоссияReferences
- Seah I, Agrawal R. Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocul Immunol Inflamm. 2020;28(3):391-5. doi: 10.1080/09273948.2020.1738501.
- World Health Organization. Coronavirus disease (COVID-19) situation report 155 [Internet]. 2020 Jun 23. Available from: https://www.who.int/docs/default-source/coronaviruse/sit-uation-reports/20200623-covid-19-sitrep-155.pdf?sfvrsn=ca01ebe_2.
- Никифоров ВВ, Суранова ТГ, Чернобров-кина ТЯ, Янковская ЯД, Бурова СВ. Новая коронавирусная инфекция (COVID-19): клинико-эпидемиологические аспекты. Архивъ внутренней медицины. 2020;10(2): 87-93. doi: 10.20514/2226-6704-2020-10-2-87-93.
- Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. О подтвержденных случаях новой коронавирусной инфекции COVID-19 в России [Интернет]. 24.06.2020. Доступно на: https://www.rospotrebnadzor.ru/about/info/news/news_details.php?ELEMENT_ID=14761.
- Брико НИ, Каграманян ИН, Никифоров ВВ, Суранова ТГ, Чернявская ОП, Полежаева НА. Пандемия COVID-19. Меры борьбы с ее распространением в Российской Федерации. Эпидемиология и вакцинопрофилактика. 2020;19(2):4-12. doi: 10.31631/2073-3046-2020-20-2-4-12.
- Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585.
- Divani AA, Andalib S, Di Napoli M, Lattan-zi S, Hussain MS, Biller J, McCullough LD, Azarpazhooh MR, Seletska A, Mayer SA, Tor-bey M. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights. J Stroke Cerebrovasc Dis. 2020;29(8): 104941. doi: 10.1016/j.jstrokecerebrovas-dis.2020.104941.
- Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, Qin Y, Xiao K, Zhang H, Sun X. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol. 2020:10.1111/aos.14472. Epub ahead of print. doi: 10.1111/aos.14472.
- Daruich A, Martin D, Bremond-Gignac D. Ocular manifestation as first sign of Coronavirus Disease 2019 (COVID-19): Interest of telemedicine during the pandemic context. J Fr Ophtalmol. 2020;43(5):389-91. doi: 10.1016/j.jfo.2020.04.002.
- Lu CW, Liu XF, Jia ZF. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020;395(10224):e39. doi: 10.1016/S0140-6736(20)30313-5.
- Marinho PM, Marcos AAA, Romano AC, Nasci-mento H, Belfort R Jr. Retinal findings in patients with COVID-19. Lancet. 2020;395(10237): 1610. doi: 10.1016/S0140-6736(20)31014-X.
- Cleary T. COVID19 and retinal OCT case study V11 [Internet]. ResearchGate. 2020 Jun. doi: 10.13140/RG.2.2.33538.09924.
- Ruamviboonsuk P, Lai TYY, Chang A, Lai CC, Mieler WF, Lam DSC; for Asia-Pacific Vitreo-Ret-ina Society. Chloroquine and Hydroxychloroquine Retinal Toxicity Consideration in the Treatment of COVID-19. Asia Pac J Ophthalmol (Phila). 2020;9(2):85–7. doi: 10.1097/APO.0000000000000289.
- Marmor MF. COVID-19 and Chloroquine/Hy-droxychloroquine: Is There Ophthalmolog-ical Concern? [Internet]. Am J Ophthalmol. 2020 May 8. doi: 10.1016/j.ajo.2020.03.029.
- Казарян АА, Пономарева ЕН. Случай глазных проявлений токсического воздействия гидроксихлорохина. Клиническая практика. 2011 ;(2):12—21.
- Министерство здравоохранения Российской Федерации. Временные методические рекомендации: профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19) [Интернет]. Версия 6 (28.04.2020). Доступно на: https://static-1.rosminzdrav.ru/system/attachments/attach-es/000/050/122/original/28042020_MR_COVID-19_v6.pdf.
- Freni F, Meduri A, Gazia F, Nicastro V, Gallet-ti C, Aragona P, Galletti C, Galletti B, Galletti F. Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585.
- Kanberg N, Ashton NJ, Andersson LM, Yilmaz A, Lindh M, Nilsson S, Price RW, Blennow K, Zetter-berg H, Gisslen M. Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19. Neurology. 2020:10.1212/ WNL.0000000000010111. Epub ahead of print. doi: 10.1212/WNL.0000000000010111.
- Armstrong RA. Oculo-Visual Dysfunction in Parkinson's Disease. J Parkinsons Dis. 2015;5(4): 715-26. doi: 10.3233/JPD-150686.
- Zachi EC, Costa TL, Barboni MTS, Costa MF, Bonci DMO, Ventura DF. Color Vision Losses in Autism Spectrum Disorders. Front Psychol. 2017;8:1127. doi: 10.3389/fpsyg.2017.01127.
- Кучина НВ, Якушина ТИ, Котов СВ, Лапитан ДГ, Андрюхина ОМ, Рябцева АА. Исследование цветового зрения для диагностики и динамического наблюдения при рассеянном склерозе. Альманах клинической медицины. 2015;(36):47-52. doi: 10.18786/2072-0505-2015-36-47-52.
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