A RARE LUNG MALIGNANCY IN A 3-YEAR-OLD CHILD

Cover Page


Cite item

Full Text

Abstract

Pleuropulmonary blastoma is a rare primary malignant tumor originating from lungs and/or pleura. It is more frequent in young children and differs from other lung neoplasms by a number of histopathological particulars. We present a clinical case of such tumor in a 3-year-old child. Initially, the disease was diagnosed as pleuropneumonia, however, computed tomography revealed a tumor originating from mediastinum. Current data indicates that diagnostics of pleuropulmonary blastoms is difficult even with the use of a full range of radiation assessment methods and participation of qualified specialists.

About the authors

G. A. Stashuk

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: stashukmoniki@mail.ru

Stashuk Galina A. – MD, PhD, Professor, Chief Research Fellow, Department of Roentgenology; Chair of Radiology, Postgraduate Training Faculty

* 61/2–1 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (495) 681 66 42. E-mail: stashukmoniki@mail.ru

Россия

D. A. Pykhteev

Moscow Regional Research and Clinical Institute (MONIKI)

Email: stashukmoniki@mail.ru
Pykhteev Dmitriy A. – PhD, Chief of Department of Pediatric Surgery Россия

I. A. Kazantseva

Moscow Regional Research and Clinical Institute (MONIKI)

Email: stashukmoniki@mail.ru
Kazantseva Irina A. – MD, PhD, Head of Department of Pathological Anatomy Россия

A. S. Khromova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: stashukmoniki@mail.ru
Khromova Asya S. – Resident, Chair of Radiology, Postgraduate Training Faculty Россия

O. S. Shpak

Moscow Regional Research and Clinical Institute (MONIKI)

Email: stashukmoniki@mail.ru
Shpak Ol'ga S. – Resident, Chair of Radiology, Postgraduate Training Faculty Россия

References

  1. Dehner LP, Watterson J, Priest JR. Pleuropulmonary blastoma. A unique intrathoracic-pulmonary neoplasm of childhood. Perspectives in Pediatric Pathology. 1995;18:214–26.
  2. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, third edition. Cancer. 2005;103(7):1457–67.
  3. Чернеховская НЕ, Федченко ГГ, Андреев ВГ, Поваляев АВ. Рентгено-эндоскопическая диагностика заболеваний органов дыхания. М.: МЕДпресс-информ; 2007. 241 c.
  4. Савва НН, Зборовская АА, Алейникова ОВ. Злокачественные новообразования у детей Республики Беларусь: заболеваемость, выживаемость, смертность и паллиативная помощь. Минск: ГУ РНМБ; 2008. 71 с.
  5. Priest JR, McDermott MB, Bhatia S, Watterson J, Manivel JC, Dehner LP. Pleuropulmonary blastoma: a clinicopathologic study of 50 cases. Cancer. 1997;80(1):147–61.
  6. Stocker JT, Hussain AN, Dehner LP. Pediatric tumors. In: Tomashefski JF, Cagle PT, Farver СF, Fraire AE, editors. Dail and Hammar's Pulmonary Pathology. 3rd edition. Vol. II. New York: Springer; 2008. p. 542–57.
  7. The International Pleuropulmonary Blastoma Registry; 1988–2014. http://www.ppbregistry.org
  8. Петрикова НИ, Ефременков АМ, Игнатьев ЕМ, Сниткин НА. Плевропульмональная бластома: собственное клиническое наблюдение. Онкопедиатрия. 2014;1(4): 52–5.
  9. Ивановская ТЕ, Гусман БС. Патологическая анатомия болезней плода и ребенка. Т. 1. М.: Медицина; 1981. 376 с.
  10. Давыдов МИ, Аксель ЕМ, ред. Статистика злокачественных образований в России и странах СНГ в 2012 г. М.: Издательская группа РОНЦ; 2014. 226 с.
  11. Barnard WG. Embryoma of lungs. Thorax. 1952;7(4):299–301.
  12. Cutler CS, Michel RP, Yassa M, Langleben A. Pulmonary blastoma: case report of a patient with a 7-year remission and review of chemotherapy experience in the world literature. Cancer. 1998;82(3):462–7.
  13. Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press; 2005. 430 p.
  14. Priest JR, Watterson J, Strong L, Huff V, Woods WG, Byrd RL, Friend SH, Newsham I, Amylon MD, Pappo A, Mahoney DH, Langston C, Heyn R, Kohut G, Freyer DR, Bostrom B, Richardson MS, Barredo J, Dehner LP. Pleuropulmonary blastoma: a marker for familial disease. J Pediatr. 1996;128(2):220–4.
  15. Vargas SO, Nose V, Fletcher JA, Perez-Atayde AR. Gains of chromosome 8 are confined to mesenchymal components in pleuropulmonary blastoma. Pediatr Dev Pathol. 2001;4(5): 434–45.
  16. Hashemi A, Souzani A, Souzani A, Keshavarzi S. Pleuropulmonary blastoma in children: a case report. Iran J Cancer Prev. 2012;5(2):105–7.
  17. Miniati DN, Chintagumpala M, Langston C, Dishop MK, Olutoye OO, Nuchtern JG, Cass DL. Prenatal presentation and outcome of children with pleuropulmonary blastoma. J Pediatr Surg. 2006;41(1):66–71.
  18. Fung CH, Lo JW, Yonan TN, Milloy FJ, Hakami MM, Changus GW. Pulmonary blastoma: an ultrastructural study with a brief review of literature and a discussion of pathogenesis. Cancer. 1977;39(1):153–63.
  19. Romeo C, Impellizzeri P, Grosso M, Vitarelli E, Gentile C. Pleuropulmonary blastoma: longterm survival and literature review. Med Pediatr Oncol. 1999;33(4):372–6.
  20. Yeh YA, Edelman MC. Lung: Pleuropulmonary blastoma. In: Atlas of Genetics and Cytogenetics in Oncology and Hematology. http:// atlasgeneticsoncology.org//Tumors/PleuropulmblastomID6040. html
  21. Corapcioğlu F, Liman T, Aksu G, Inan N, Deveci M, Gurbuz Y, Topcu S. A case report with type II pleuropulmonary blastoma: successful treatment with surgery and chemotherapy. Turk J Pediatr. 2009;51(1):78–81.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Stashuk G.A., Pykhteev D.A., Kazantseva I.A., Khromova A.S., Shpak O.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies