The relationship of sleep mechanisms and epileptogenesis

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Close links between epilepsy and sleep is doubtless; however, the available literature does not allow for its unequivocal interpretation from the common pathophysiological mechanisms' perspective. GABAergic neuronal deficiency is believed to be the neurochemical background of the intimate mechanisms of sleep and epileptogenesis. Sleep impacts the epileptiform activity, with an increase in epileptiform discharge during NREM and a decrease during REM phases. Sleep deprivation may complicate the course of epilepsy, while epileptic attacks may change the sleep structure and quality. Anti-epileptic agents exert diverse effects on the sleep architectonics; they can induce sedation or increase alertness. Our potential to correct the results of the pathological interplay between sleep mechanisms and epilepsy are rather limited and are frequently overestimated by clinicians. Investigation of the interrelationship between epileptic seizures and sleep and the use of polysomnography can substantially add to the diagnosis of the epileptic syndrome and define the subsequent outcomes.

About the authors

A. B. Kozhokaru

State Research Center – Burnasyan Federal Medical Biophysical Center;
Central State Medical Academy of the Presidential Administration of the Russian Federation

Author for correspondence.

Anzhela B. Kozhokaru – MD, PhD, Chief of the Laboratory of Clinical Neurophysiology; Associate Professor, Chair of Neurology.

46 Zhivopisnaya ul., Moscow, 123182;
19/1A Marshala Timoshenko ul., Moscow, 121359
23 Marshala Novikova ul., Moscow, 123098
Tel.: +7 (916) 245 56 41 

Russian Federation

P. N. Vlasov

A.I. Yevdokimov Moscow State University of Medicine and Dentistry (MSUMD)


Pavel N. Vlasov – MD, PhD, Professor, Neurology Department.

20/1 Delegatskaya ul., Moscow, 127473

Russian Federation

A. S. Orlova

I.M. Sechenov First Moscow State Medical University


Aleksandra S. Orlova – MD, PhD, Associate Professor, Department of Human Pathology, Institute of Clinical Medicine.

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation


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