EFFECT OF OOCYTES QUALITY AND OVARIAN RESERVE ON THE THERAPEUTIC POTENTIAL OF IN VITRO FERTILIZATION IN PATIENTS OF LATE REPRODUCTIVE AGE

Cover Page


Cite item

Full Text

Abstract

The paper discusses the interference of the quality of oocytes and ovarian reserve status in the therapeutic potential of in vitro fertilization in women of late reproductive age. It was substantiated that the age factor decreased both female fertility and possibility of the successful fertilization.

About the authors

E. V. Krstic

LLC Clinic of Health, group of companies “Mother and Child”

Email: fake@neicon.ru

MD, PhD, physician obstetrician-gynecologist, reproductor of the “Clinic of Health”, Ltd., Group of companies “Mother and a Child”

Russian Federation

M. Krstic

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., 129110 Moscow, Russian Federation
Family Clinic, Ltd., the Net of Family Centers; 5/2 s.1 Sergiya Radonezhskogo ul., 105120 Moscow, Russian Federation

Author for correspondence.
Email: dolce-vita07@mail.ru

MD, PhD, physician-urologist, Surgical Department of Organ Donorship, MONIKI; physician-urologist of the “Family clinic”, Ltd., “The Net of the Family Medical Centers”

Russian Federation

V. N. Yudaev

Moscow Regional Research and Clinical Institute (MONIKI); 61/2 Shchepkina ul., 129110 Moscow, Russian Federation

Email: fake@neicon.ru

MD, PhD, Professor, the Chair of Obstetrics and Gynecology, the Faculty of Postgraduate Medical Training, MONIKI

Russian Federation

References

  1. Кустаров В.Н., Боярский К.Ю. Влияние возраста на частоту наступления беременности в программе ЭКО. Проблемы репродукции 1999;(1):46-9. [Kustarov V.N., Boyarskiy K.Yu. Age effect on fertilization rate using IVF program. Problemy reproduktsii 1999;(1):46-9 (in Russian)].
  2. Назаренко Т.А., Мишиева Н.Г., Фанченко Н.Д., Соловьева Н.Г., Муллабаева С.М., Белоусова Н.Ю. Значение оценки овариального резерва в лечении бесплодия у женщин старшего репродуктивного возраста. Проблемы репродукции 2005;(2):56-9. [Nazarenko T.A., Mishieva N.G., Fanchenko N.D., Solov’eva N.G., Mullabaeva S.M., Belousova N.Yu. Significance of ovarian reserve assessment in treatment of infertility in women of the late reproductive age. Problemy reproduktsii 2005;(2):56-9 (in Russian)].
  3. Тишкевич О.Л., Жабинская А.Б., Малышева Е.В. Клинико-эмбриологическая оценка результатов экстракорпорального оплодотворения в зависимости от возраста пациенток. Проблемы репродукции 2004;(2):33-7. [Tishkevich O.L., Zhabinskaya A.B., Malysheva E.V. Clinical-and-embriologic assessment of in vitro fertilization outcome depending on patients’ age. Problemy reproduktsii 2004;(2):33-7 (in Russian)].
  4. Battaglia D.E., Goodwin P., Klein N.A., Soules M.R. Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod 1996;11(10):2217-22.
  5. Wells D., Delhanty J.D. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol Hum Reprod 2000;6(11):1055-62.
  6. Белоцерковцева Л.Д., Коноваленко Л.В., Корнеева Е.В., Бондарева Е.В., Шишанок О.Ю. Влияние возраста пациенток на частоту биологических потерь в программах ЭКО: опыт работы. Проблемы репродукции 2008;(3):53-6. [Belotserkovtseva L.D., Konovalenko L.V., Korneeva E.V., Bondareva E.V., Shishanok O.Yu. Effect of women’ s age on the frequency of biological losses in implications of IVF program: investigation experience. Problemy reproduktsii 2008;(3):53-6 (in Russian)].
  7. Назаренко Т.А., Финогенова Е.Я., Осина О.А. Донация ооцитов в программе ЭКО и ПЭ. Экстракорпоральное оплодотворение и его новые направления в лечении женского и мужского бесплодия (теоретические и практические подходы). Кулаков В.И., Леонов Б.В., ред. М.: МИА; 2000. [Nazarenko T.A., Finogenova E.Ya., Osina O.A. Oocytes donation using IVF and ЕТ programs. In vitro fertilization and its new directions in treatment of female and male infertility (theoretic and practical approaches). Kulakov V.I., Leonov B.V., editors. Moscow: MIA; 2000 (in Russian)].
  8. Cohen M.A., Lindheim S.R., Sauer M.V. Donor age is paramount to success in oocyte donation. Hum Reprod 1999; 14(11):2755-8.
  9. Назаренко Т.А., Здановский В.М., Дуринян Э.Р., Чечурова Т.Н., Мишиева Н.Г., Смирнова А.А. Синдром поликистозных яичников (современные подходы к диагностике и лечению бесплодия). М.: МЕДпресс-информ; 2005. [Nazarenko T.A., Zdanovskiy V.M., Durinyan E.R., Chechurova T.N., Mishieva N.G., Smirnova A.A. Syndrome of polycystic ovaries (contemporary approaches to infertility diagnosis and treatment). Moscow: MED-press-inform; 2005 (in Russian)].
  10. Назаренко Т.А., Мишиева Н.Г., Абубакиров А.Н., Жорданидзе Д.О. Овариальный резерв в прогнозе лечения бесплодия. Проблемы репродукции (специальный выпуск «Второй международный конгресс по репродуктивной медицине»); 2008. [Nazarenko T.A., Mishieva N.G., Abubakirov A.N., Zhordanidze D.O. Ovarian reserve in prognosis of infertility treatment. Problemy reproduktsii (special issue «Vtoroy mezhdunarodnyy kongress po reproduktivnoy meditsine»); 2008 (in Russian)].
  11. Александрова Н.В., Марченко Л.А. Современные подходы к оценке овариального резерва у женщин с преждевременной недостаточностью яичников (обзор литературы). Проблемы репродукции 2007;(2):22-9. [Aleksandrova N.V., Marchenko L.A. Contemporary approaches to the ovarian reserve assessment in women with premature ovarian insufficiency (review of the literature). Problemy reproduktsii 2007;(2)22-9 (in Russian)].
  12. Боярский К.Ю. Фолликулогенез и современная овариальная стимуляция (обзор литературы). Проблемы репродукции 2002;(3):36-43. [Boyarskiy K.Yu. Follicular genesis and contemporary ovarian stimulation (review of the literature). Problemy reproduktsii 2002;(3):36-43 (in Russian)].
  13. Faddy M.J., Gosden R.G. A mathematical model of follicle dynamics in human ovary. Hum Reprod 1995;10(4):770-5.
  14. Faddy M.J., Gosden R.G., Gougeon A., Richardson S.J., Nelson J.F. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod 1992; 7(10):1342-6.
  15. Richardson S.J., Senikas V., Nelson J.F. Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrin Metab 1987;65:1231-7.
  16. Назаренко Т.А., Краснопольская К.В. «Бедный ответ». Тактика ведения пациенток со сниженной реакцией на стимуляцию гонадотропинами в программах ЭКО. М.: МЕДпресс-информ;
  17. [Nazarenko T.A., Krasnopol'skaya K.V. “Poor response”. Management tactics in female patients with decreased reaction to gonadotrophin stimulation in IVF programs. Moscow: MED-press-inform; 2005 (in Russian)].
  18. Azem F., Yaron Y., Amit A., Yovel I., Barak Y., Peyser M.R., David M.P., Lessing J.B. How many embryos to transfer in patients undergoing IVF? Hum Reprod 1996;11(1):229-30.
  19. Ebrahim A., Rienhardt G., Morris S., Kruger T.F., Lombard C.J., Van der Merwe J.P. Follicle stimulating hormone levels on cycle day 3 predict ovulation stimulation response. J Assist Reprod Genet 1993;10(2):130-6.
  20. Licciardi F., Liu H., Rosenwaks Z. Day 3 estradiol serum concentrations as prognosticators of ovarian stimulation response and pregnancy outcome in patients undergoing in vitro fertilization. Fertil Steril 1995;64(5):991-4.
  21. Cook C.L., Siow Y., Brenner A.G., Fallat M.E. Relationship between serum müllerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women. Fertil Steril 2002;77(1):141-6.
  22. Jacob S., Conroy R., Hurrison R.F. Predictive value of day 3 menstrual cycle FSH in young women (<35 years) undergoing assisted reproduction treatment (ART). Hum Reprod 2000;15:23.
  23. Howles C., McNamee M., Edwards R. Effect of tonic level of LH on outcome of IVF. Lancet 1994;6:521-2.
  24. Hansen L.M., Batzer F.R., Gutmann J.N., Corson S.L., Kelly M.P., Gocial B. Evaluating ovarian reserve: follicle stimulating hormone and oestradiol variability during cycle days 2-5. Hum Reprod 1996;11(3):486-9.
  25. Kahraman S., Vicdan K., Işik A.Z., Ozgün O.D., Alaybeyoğlu L., Polat G., Biberoğlu K. Clomiphene citrate challenge test in the assessment of ovarian reserve before controlled ovarian hyperstimulation for intracytoplasmic sperm injection. Eur J Obstet Gynec Reprod Biol 1997;73(2):177-82.
  26. Ranieri D.M., Quinn F., Makhlouf A., Khadum I., Ghutmi W., McGarrigle H., Davies M., Serhal P. Simultaneous evaluation of basal follicle-stimulating hormone and 17 beta-estradiol response to gonadotropin-releasing hormone analogue stimulation: an improved predictor of ovarian reserve. Fertil Steril 1998;70(2):227-33.
  27. Engmann L., Sladkevicius P., Agraval R., Bekir J., Campbell S., Tan S.L. The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. Ultrasound Obstet Gynecol 1999;13(1):26-33.
  28. Kyei-Mensah A., Zaidi J., Pittrof R., Shaker A., Campbell S., Tan S.L. Transvaginal three-dimensional ultrasound: accuracy of follicular volume measurements. Fertil Steril 1996;65(2):371-6.
  29. Sharara F.I., McClarmock H.D. Baseline ovarian volume predict stimulation response but not pregnancy outcome in IVF. Hum Reprod 2000;15:28.
  30. Chang M.Y., Chiang C.H., Hsieh T.T., Soong Y.K., Hsu K.H. Use of the antral follicle count to predict the outcome of assisted reproductive technologies. Fertil Steril 1998;69(3):505-10.
  31. Child T.J., Guleki B., Tan S.L. Success during in vitro maturation (IVM) of oocyte treatment is dependent on the numbers of oocytes retrieved which are predicted by early follicular phase transvaginal ultrasound measurement of the antral follicle count and peak ovarian stromal blood flow velocity. Hum Reprod 2001;16:41.
  32. Fanchin R., Méndez Lozano D.H., Schonäuer L.M., Cunha-Filho J.S., Frydman R. Hormonal manipulation in the luteal phase to coordinate subsequent antral follicle growth during ovarian stimulation. Reprod Biomed Online 2005;10(6):721-8.
  33. Назаренко Т.А., Смирнова А.А. Индукция моно- и суперовуляции: оценка овариального резерва, ультразвуковой и гормональный мониторинг. Проблемы репродукции 2004;(1):36-42. [Nazarenko T.A., Smirnova A.A. Induction of mono- and superovulation: assessment of ovarian reserve, ultrasound and hormone monitoring. Problemy reproduktsii 2004;(1):36-42 (in Russian)].
  34. Lass A., Skull J., McWeigh E., Margara R., Winston R.M. Measurement of ovarian volume by transvaginal sonography before ovulation induction with human menopausal gonadotrophin for in-vitro fertilization can predict poor response. Hum Reprod 1997;12(12):294-7.
  35. Coulam C.B., Rinchart J.S. Baseline ovarian stromal blood flow predicts pregnancy after in vitro fertilization. Fertil Steril 1998; 70(3 Suppl 1):181.
  36. Engmann L., Sladkevicius P., Agraval R. The value of stromal blood flow velocity measurement after pituitary suppression in the prediction of ovarian responsiveness and outcome of IVF treatment. Fertil Steril 1998;70(3 Suppl 1):S105-6.
  37. Deffieux X., Antoine J.M. Inhibins, activins and anti-Mullerian hormone: structure, signaling pathways, actions and clinical relevance in assisted reproductive therapy. Gynecol Obstet Fertil 2003;31(11):900-11.
  38. de Vet A., Laven J.S., de Jong F.H., Themmen A.P., Fauser B.C. Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril 2002;77(2):357-62.
  39. Teixeira J., Maheswaran S., Donahoe P.K. Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocr Rev 2001;22(5): 657-74.
  40. Casper F.W., Seufert R.J., Schaffrath M., Pollow K. Concentrations of inhibins and activin in women undergoing stimulation with recombinant follicle-stimulating hormone for in vitro fertilization treatment. Fertil Steril 2001;75(1):32-7.
  41. Khalaf Y., Sheward V., Wheeler M. Correlation between serum levels of LH, oestradiol, and inhibin A and inhibin B and outcome of ovarian stimulation for IVF using pure FSH following pituitary down-regulation with mid-luteal GnRH agonist. Hum Reprod 2001;16:150.
  42. Tinkanen H., Bläuer M., Laippala P., Tuohimaa P., Kujansuu E. Correlation between serum inhibin B and other indicators of the ovarian function. Eur J Obstet Gynecol Reprod Biol 2001;94(1): 109-13.
  43. Назаренко Т.А., Мишиева Н.Г., Соловьева Н.Г., Фанченко Н.Д., Муллабаева С.М., Ревишвили Н.А. Ингибин В как маркер овариального резерва у женщин с различными формами бесплодия. Проблемы репродукции 2005;(3):15-9. [Nazarenko T.A., Mishieva N.G., Solov’eva N.G., Fanchenko N.D., Mullabaeva S.M., Revishvili N.A. Inhibin B as a marker of ovarian reserve in women with different forms of infertility. Problemy reproduktsii 2005;(3):15-9 (in Russian)].
  44. Черных В.Б., Курило Л.Ф. Синдром персистенции мюллеровых протоков (обзор литературы). Проблемы репродукции 2001;(4):20-3. [Chernykh V.B., Kurilo L.F. Syndrome of Müllerian ducts persistence (review of the literature). Problemy reproduktsii 2001;(4):20-3 (in Russian)].
  45. La Marca A., Malmusi S., Guillini S., Tamaro L.F., Orvieto R., Levratti Р., Volpe A. Anti-Müllerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation. Hum Reprod 2004;19(12):2738-41.
  46. Fanchin R., Schonäuer L.M., Righini C., Guibourdenche J., Frydman R., Taieb J. Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 2003;18(2):323-7.
  47. Penarrubia J., Fabreques F., Manau D., Creus M., Casals G., Casamitjana R., Carmona F., Vanrell J.A., Balasch J. Basal and stimulation day 5 anti-Mullerian hormone serum concentrations as predictors of ovarian response and pregnancy in assisted reproductive technology cycles stimulated with gonadotropin-releasing hormone agonist-gonadotropin treatment. Hum Reprod 2005;20(4): 915-22.
  48. Назаренко Т.А., Мишиева Н.Г., Фанченко Н.Д. Роль антимюллерова гормона в оценке овариального резерва. Проблемы репродукции 2005;(6):26-30. [Nazarenko T.A., Mishieva N.G., Fanchenko N.D. Role of anti-Müllerian hormone in assessment of ovarian reserve. Problemy reproduktsii 2005;(6):26-30 (in Russian)].

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Krstic E.V., Krstic M., Yudaev V.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies