НОВООБРАЗОВАНИЯ ПРИ АКРОМЕГАЛИИ

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Аннотация

Акромегалия – редкое заболевание, характеризующееся повышенной секрецией соматотропного гормона, что наиболее часто обусловлено наличием аденомы гипофиза. Отсутствие своевременного лечения акромегалии ведет к  преждевременной смерти больных, связанной с  повышением частоты развития острых сердечно-сосудистых осложнений, апноэ сна, метаболических нарушений и злокачественных новообразований. Частота злокачественных новообразований при акромегалии составляет от  4,5 до  25% (при этом механизмы их развития имеют ряд отличительных особенностей),  в  9–50%  случаев они становятся причиной гибели пациентов. При акромегалии общая смертность и смертность от онкологических заболеваний коррелирует с активностью заболевания. Установлена прямая зависимость между высоким уровнем инсулиноподобного ростового фактора 1 крови и риском развития злокачественных опухолей. У больных акромегалией наиболее часто встречаются злокачественные новообразования толстого кишечника (1–20%) и  щитовидной железы (7,8–11%). В  обзоре литературы отражены результаты эпидемиологических исследований злокачественных новообразований, а также некоторые аспекты их патогенеза у больных акромегалией.

Об авторах

И. Д. Чих

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация

Email: trigolosova_ira@mail.ru
заведующая отделением терапевтической эндокринологии Россия

И. В. Триголосова

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация

Автор, ответственный за переписку.
Email: trigolosova_ira@mail.ru
канд. мед. наук, ст. науч. сотр. отделения терапевтической эндокринологии Россия

А. В. Древаль

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»; 129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация

Email: trigolosova_ira@mail.ru
д-р мед. наук, профессор, руководитель отделения терапевтической эндокринологии, заведующий кафедрой эндокринологии факультета усовершенствования врачей Россия

А. В. Триголосов

ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России; 115478, г. Москва, Каширское шоссе, 24, Российская Федерация

Email: trigolosova_ira@mail.ru
канд. мед. наук, ст. науч. сотр. отделения радиохирургии Россия

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