Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

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Abstract

Aims: 1) To evaluate an association between the fat fraction (FF) and bone mineral density (BMD) measured by localized proton magnetic resonance spectroscopy (1H-MRS) and quantitative computed tomography (QCT) densitometry, respectively, in healthy vertebrae of children after a compression fracture; 2) To compare the FF and BMD values with the severity of the compression vertebrae fractures.

Materials and methods: Twenty (20) patients (aged 11.1±2.1 years) with a trauma-induced compression vertebral fractures participated in the study. The BMD of L3, L4 vertebrae (mg/cm3) was measured in by QCT (Philips Brilliance 16). FF in the same area was measured from 1H-MR-spectra (STEAM, echo time (TE)=12.8 ms, repetition time (TR)=3000 ms, voxel size=20×15×10 mm) using Philips Achieva TX 3.0T MRI scanner.

Results: Correlation analysis revealed a  significant inverse linear correlation (r=-0.55, p=0.0004) between FF and BMD of L3 и L4 vertebrae. In addition, in the patients with severe compression vertebral fracture (more than 2 fractured vertebrae) there was a  significant increase in FF values and a  BMD decrease, compared to the values in the patients with mild fractures (1–2 fractured vertebrae).

Conclusion: The correlation suggests that the increase of FF in the bone marrow and the decrease of BMD in children go in parallel. Therefore, 1H-MRS could be an alternative to QCT and dual-energy X-ray absorptiometry. The absence of radiation load allows for recommendation to use 1Н-MRS for screening and follow-up, as well as for the control of BMD.

About the authors

A. S. Ivantsova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Anna S. Ivantsova – Junior Research Fellow, Postgraduate Student 

22 Bol'shaya Polyanka ul., Moscow, 119180

Russian Federation

P. E. Menshchikov

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences;
Philips Healthcare LLC

Author for correspondence.
Email: petr.menshchikov@philips.com

Petr E. Menshchikov – PhD (in Phys. and Math.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Junior Research Fellow N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences; Scientific Projects Support Specialist Philips Healthcare LLC

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991;
13 Sergeya Makeeva ul., Moscow, 123022

Russian Federation

U. A. Polyakova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Ul'yana A. Polyakova – Radiologist, Department of Radiological Methods 

22 Bol'shaya Polyanka ul., Moscow, 119180

Russian Federation

A. V. Manzhurtsev

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru

Andrey V. Manzhurtsev – PhD (in Phys. and Math.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Junior Research Fellow, Laboratory of Kinetics and Mechanisms of Enzymatic and Catalytic Reactions Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991

Russian Federation

M. V. Ublinskiy

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru
ORCID iD: 0000-0002-4627-9874

Maxim V. Ublinskiy – PhD (in Biol.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Research Fellow Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991

Russian Federation

T. A. Akhadov

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Tolibdzhon A. Akhadov – MD, PhD, Professor, Head of Department of Radiological Methods 

22 Bol'shaya Polyanka ul., Moscow, 119180

Russian Federation

D. A. Kupriyanov

Philips Healthcare LLC

Email: fake@neicon.ru

Dmitriy A. Kupriyanov – PhD (in Phys. and Math.), Scientific Projects Support Senior Specialist

13 Sergeya Makeeva ul., Moscow, 123022

Russian Federation

N. A. Semenova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru

Nataliya A. Semenova – Doctor of Biol. Sci., Chief Research Fellow Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Research Fellow N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences; Chief Research Fellow Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991;
4 Kosygina ul., Moscow, 119334

Russian Federation

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Copyright (c) 2021 Ivantsova A.S., Menshchikov P.E., Polyakova U.A., Manzhurtsev A.V., Ublinskiy M.V., Akhadov T.A., Kupriyanov D.A., Semenova N.A.

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