Предотвращение эпилептогенеза как будущая стратегия терапии эпилепсии

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Эпилепсией страдают более 70 млн человек во всем мире. От 30 до 40% больных резистентны к  существующим лекарственным средствам. В статье описано современное состояние терапии эпилепсии и  предложен возможный подход к превентивной терапии на ранних стадиях эпилептогенеза. Для прогнозирования развития эпилепсии на ее ранних стадиях нужны биомаркеры. Единственным приемлемым биомаркером эпилептогенеза следует признать патологические высокочастотные осцилляции. Однако главное ограничение метода – необходимость имплантации электродов для их регистрации. Одной из актуальнейших тем научных исследований эпилепсии представляется поиск неинвазивных биомаркеров эпилептогенеза. В свою очередь, в этой области существуют два потенциально интересных направления: поиск воспалительных биомаркеров в  периферической крови и  анализ различных параметров, которые дают визуализирующие методы. В этой публикации мы освещаем подходы к  определению потенциальных биомаркеров эпилептогенеза с  помощью магнитно-резонансной томографии. Некоторые из параметров магнитно-резонансной томографии коррелируют с  наличием патологических высокочастотных осцилляций, могут косвенно отражать текущий воспалительный процесс в головном мозге и  стать возможными биомаркерами эпилептогенеза.

Об авторах

А. Г. Брагин

Калифорнийский университет (Лос-Анджелес)

Автор, ответственный за переписку.
Email: abragin@mednet.ucla.edu
ORCID iD: 0000-0003-1207-8481

Брагин Анатолий Григорьевич - доктор биологических наук, научный сотрудник отделения неврологии Центра по эпилепсии.

90095, Калифорния, Лос-Анджелес, Вествуд Плаза, 710

США

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