The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation

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Abstract

The aim of the present review is to find an answer to the clinically important question on the mechanisms regulating the activity of reparative regeneration in hypoxic conditions and potential ways to modify this process. In the recent studies, compensated hypoxia is characterized as a trigger for the regeneration, with the central regulating factor being the member of the cytokine family, hypoxia-inducible factor-1 (HIF-1). Changes in the concentration of this protein modulates cell migration, angiogenesis and epithelialmesenchymal integration; it also stimulates the proliferation of endothelial cells and fibroblasts, playing a  major role in the stimulation of wound healing, especially with compromised microcirculation, for example, diabetes mellitus.

 

About the authors

S. G. Izmaylov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Surgical Diseases Россия

V. V. Beschastnov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Россия

M. G. Ryabkov

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Surgical Diseases Россия

A. E. Leont'ev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Россия

E. E. Lukoyanychev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Associate Professor, Chair of Surgical Diseases Россия

M. V. Bagryantsev

Сity Clinical Hospital No 30 of Moscow District (Nizhniy Novgorod);
Nizhny Novgorod State Medical Academy

Author for correspondence.
Email: maks-bagryancev@mail.ru
PhD Student, Chair of Surgical Diseases Россия

N. Yu. Orlinskaya

Nizhny Novgorod State Medical Academy

Email: fake@neicon.ru
MD, PhD, Professor, Chair of Pathological Anatomy Россия

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Copyright (c) 2017 Izmaylov S.G., Beschastnov V.V., Ryabkov M.G., Leont'ev A.E., Lukoyanychev E.E., Bagryantsev M.V., Orlinskaya N.Y.

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