The Russian consensus on diagnosis and treatment of coeliac disease in children and adults

Abstract

Accepted at 42nd Scientific Session of the Central Research Institute of Gastroenterology, Moscow, March 2-3, 2016.

The consensus has been developed by the leading experts in gastroenterology and pediatrics of Russia. It is based on the guidelines "Gluten enteropathy an interdisciplinary disease" (2006) and "Diagnosis and treatment of coeliac disease in children" (2010), the guidelines of the Society of Pediatric Gastroenterologists of Russia "Diagnosis and treatment of coeliac disease in children" (2010), the Federal clinical guidelines on medical care for children with coeliac disease developed by the Union of Russian Pediatricians (2015), Diagnostic criteria of coeliac disease by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (revised ESPGHAN criteria, 1990), American College of Gastroenterology Clinical Guideline: "Diagnosis and management of celiac disease" (2013), "Diagnosis and Management of Adult Coeliac Disease: Guidelines from the British Society of Gastroenterology" (2014), and approved by the 42nd Scientific session of the Central Research Institute of Gastroenterology (CRIG) "The principles of evidence-based medicine into clinical practice" (Moscow, March 2-3, 2016). The consensus is published in its short version: the document sections on diagnosis and treatment of adult coeliac disease are presented.

References

  1. Lanzini A, Villanacci V, Apillan N, Lanzarotto F, Pirali F, Amato M, Indelicato A, Scarcella C, Donato F. Epidemiological, clinical and histo-pathologic characteristics of celiac disease: results of a case-finding population-based program in an Italian community. Scand J Gastroenterol. 2005;40(8):950-7. doi: 10.1080/00365520510023107.
  2. Catassi C, Kryszak D, Louis-Jacques O, Duerk-sen DR, Hill I, Crowe SE, Brown AR, Procacci-ni NJ, Wonderly BA, Hartley P, Moreci J, Bennett N, Horvath K, Burk M, Fasano A. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102(7):1454-60. doi: 10.1111/j.1572-0241.2007.01173.x.
  3. Abu-Zekry M, Kryszak D, Diab M, Catassi C, Fa-sano A. Prevalence of CD in Egyptian children disputes the east-west agriculture-dependent spread of the disease. J Pediatr Gastroenter-ol Nutr. 2008;47:136-40. doi: 10.1097/MPG.0b013e31815ce5d1.
  4. Парфенов АИ. Целиакия. Эволюция представлений о распространенности, клинических проявлениях и значимости этиотроп-ной терапии. М.: Анахарсис; 2007. 376 с.
  5. Стройкова МВ. Скрининг населения центрального региона России на антитела класса IgA к тканевой трансглутаминазе и применение данного метода обследования для диагностики целиакии у детей: Автореф. дисс. ... Кандидат медицинских наук. М.; 2007.
  6. Кондратьева ЕИ, Щербаков ПЛ, Бельмер СВ, Янкина ГН. О регистре больных целиакией. Сибирский вестник гепатологии и гастроэнтерологии. 2007;(20):67-8.
  7. Jabri B, Sollid LM. Mechanisms of disease: im-munopathogenesis of celiac disease. Nat Clin Pract Gastroenterol Hepatol. 2006;3(9):516-25. doi: 10.1038/ncpgasthep0582.
  8. Owens SR, Greenson JK. The pathology of malabsorption: current concepts. Histopathol- ogy. 2007;50(1):64-82. doi: 10.1111/j.1365-2559.2006.02547.x.
  9. Kaukinen K, Partanen J, Maki M, Collin P. HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol. 2002;97(3):695-9. doi: 10.1111/j.1572-0241.2002.05471.x.
  10. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008;103(1):190-5. doi: 10.1111/j.1572-0241.2007.01471.x.
  11. Rostom A, Dube C, Cranney A, Saloojee N, Sy R, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, MacNeil J, Mack D, Patel D, Moher D. The diagnostic accuracy of serolog-ic tests for celiac disease: a systematic review. Gastroenterology. 2005;128(4 Suppl 1):S38-46.
  12. Rashtak S, Ettore MW, Homburger HA, Murray JA. Combination testing for antibodies in the diagnosis of coeliac disease: comparison of multiplex immunoassay and ELISA methods. Aliment Pharmacol Ther. 2008;28(6):805-13.
  13. Kurppa K, Collin P, Viljamaa M, Haimila K, Saav-alainen P, Partanen J, Laurila K, Huhtala H, Paasikivi K, Maki M, Kaukinen K. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology. 2009;136(3):816-23. doi: 10.1053/j.gas-tro.2008.11.040.
  14. Захарова ИН, Боровик ТЭ, Рославцева ЕА, Андрюхина ЕН, Дмитриева ЮА, Дзебисо-ва ФС. Целиакия у детей: решенные и нерешенные вопросы этиопатогенеза. Вопросы современной педиатрии. 2011;10(4):30-5.
  15. Парфенов АИ, Крумс ЛМ, Сабельникова ЕА. Классификация целиакии. Медицинская кафедра. 2005;(4):65-70.
  16. Парфенов АИ. Энтерология: руководство для врачей. 2-е изд. М.: МИА; 2009. 880 с.
  17. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasa-no A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62(1):43-52. doi: 10.1136/gutjnl-2011-301346.
  18. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenter-ology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108(5):656-76. doi: 10.1038/ajg.2013.79.
  19. Захарова ИН, Боровик ТЭ, Рославцева ЕА, Андрюхина ЕН, Дмитриева ЮА. Клинические варианты целиакии в практике педиатра. Вопросы диагностики в педиатрии. 2011;3(6):52-8.
  20. Проект рабочего протокола диагностики и лечения целиакии у детей. Вопросы детской диетологии. 2004;2(1):92-9.
  21. Ревнова МО. Целиакия у детей новый взгляд на старую проблему. Русский медицинский журнал. 2008;16(18):1209-12.
  22. Копишинская СВ, Светозарский СН, Гу-стов АВ. Глютеновая атаксия: патогенез, клиника, диагностика и лечение. Неврологический вестник. Журнал имени В.М. Бехтерева. 2015;67(1):39-45.
  23. Парфенов АИ. Неврологические и психические нарушения у больных глютенчувстви-тельной целиакией. Гастроэнтерология. Приложение к журналу Consilium Medicum. 2009;(1):46-50.
  24. Cross AH, Golumbek PT. Neurologic manifestations of celiac disease: Proven, or just a gut feeling? Neurology. 2003;60(10):1566-8.
  25. Hadjivassiliou M, Grunewald RA, Da-vies-Jones GA. Gluten sensitivity as a neurological illness. J Neurol Neurosurg Psychiatry. 2002;72(5):560-3. doi: 10.1136jnnp.72.5.560.
  26. Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q. 2012;83(1):91-102. doi: 10.1007/s11126-011-9186-y.
  27. Pengiran Tengah DS, Wills AJ, Holmes GK. Neurological complications of coeliac disease. Postgrad Med J. 2002;78(921):393-8.
  28. Nikpour S. Neurological manifestations, diagnosis, and treatment of celiac disease: A comprehensive review. Iran J Neurol. 2012;11(2):59-64.
  29. Bushara KO. Neurologic presentation of celiac disease. Gastroenterology. 2005;128(4 Suppl 1): S92-7. doi: 10.1053/j.gastro.2005.02.018.
  30. Freeman HJ. Neurological disorders in adult celiac disease. Can J Gastroenterol. 2008;22(11):909-11.
  31. Сабельникова ЕА, Парфенов АИ, Крумс ЛМ, Гудкова РБ. Целиакия как причина железо-дефицитной анемии. Терапевтический архив. 2006;78(2):45-8.
  32. Сабельникова ЕА, Полева НИ, Гудкова РБ. Железодефицитная анемия типичный симптом целиакии. В: Тезисы VI съезда научного общества гастроэнтерологов России. М.: Анахарсис; 2006. с. 170.
  33. Филатов ЛБ, Берман ВБ. Железодефицитная анемия как следствие нарушения всасывания при целиакии. Клиническая онкогема-тология. Фундаментальные исследования и клиническая практика. 2010;3(3):284-8.
  34. Mody RJ, Brown PI, Wechsler DS. Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease. J Pediatr Hematol Oncol. 2003;25(2):169-72.
  35. Javid G, Lone SN, Shoukat A, Khan BA, Yat-too GN, Shah A, Sodi JS, Khan MA, Zarger SA. Prevalence of celiac disease in adult patients with iron-deficiency anemia of obscure origin in Kashmir (India). Indian J Gastroenterol. 2015;34(4):314-9. doi: 10.1007/s12664-015-0586-z.
  36. Halfdanarson TR, Litzow MR, Murray JA. He-matologic manifestations of celiac disease. Blood. 2007;109(2):412-21. doi: 10.1182/blood-2006-07-031104.
  37. Mant MJ, Bain VG, Maguire CG, Murland K, Yacyshyn BR. Prevalence of occult gastrointestinal bleeding in celiac disease. Clin Gastroenterol hepatol. 2006;4(4):451-4. doi: 10.1016/j.cgh.2005.12.010.
  38. Hue S, Mention JJ, Monteiro RC, Zhang S, Cellier C, Schmitz J, Verkarre V, Fodil N, Bah-ram S, Cerf-Bensussan N, Caillat-Zucman S. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004;21(3):367-77. doi: 10.1016/j.immu-ni.2004.06.018
  39. Сабельникова ЕА, Парфенов АИ, Царегород-цева ТМ, Ткачев ВД, Топорков АС, Чикуно-ва БЗ, Шепеева СД. Изменения печени при глютеновой энтеропатии. Терапевтический архив. 2003;75(2):31-4.
  40. Sainsbury A, Sanders DS, Ford AC. Meta-anal-ysis: Coeliac disease and hypertransaminasae-mia. Aliment Pharmacol Ther. 2012;34(1):33-40. doi: 10.1111/j.1365-2036.2011.04685.x.
  41. Korpimaki S, Kaukinen K, Collin P, Haapa-la AM, Holm P, Laurila K, Kurppa K, Saav-alainen P, Haimila K, Partanen J, Maki M, Lahdeaho ML. Gluten-sensitive hypertrans-aminasemia in celiac disease: an infrequent and often subclinical finding. Am J Gastroenterol. 2011;106(9):1689-96. doi: 10.1038/ ajg.2011.134.
  42. Duggan JM, Duggan AE. Systematic review: the liver in coeliac disease. Aliment Pharmacol Ther. 2005;21(5):515-8. doi: 10.1111/j.1365-2036.2005.02361.x.
  43. Emami MH, Hashemi M, Kouhestani S, Taheri H, Karimi S. Should we look for celiac disease among all patients with liver function test abnormalities? Int J Prev Med. 2012;3(3):167-72.
  44. Kaukinen K, Halme L, Collin P, Farkkila M, Maki M, Vehmanen P, Partanen J, Hockerst-edt K. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122(4):881-8.
  45. Rubio-Tapia A, Abdulkarim AS, Wiesner RH, Moore SB, Krause PK, Murray JA. Celiac disease autoantibodies in severe autoimmune liver disease and the effect of liver transplantation. Liver Int. 2008;28(4):467-76. doi: 10.1111/j.1478-3231.2008.01681.x.
  46. Di Simone N, Silano M, Castellani R, Di Nic-uolo F, D'Alessio MC, Franceschi F, Tritarel-li A, Leone AM, Tersigni C, Gasbarrini G, Sil-veri NG, Caruso A, Gasbarrini A. Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro. Am J Gastroenterol. 2010;105(10):2254-61. doi: 10.1038/ajg.2010.233.
  47. Hadziselimovic F, Geneto R, Buser M. Celi-ac disease, pregnancy, small for gestational age: role of extravillous trophoblast. Fetal Pediatr Pathol. 2007;26(3):125-34. doi: 10.1080/15513810701563637.
  48. Bona G, Martinello D, Oderda G. Mechanisms of abnormal puberty in celiac disease. Horm Res. 2002;57 Suppl 2:63-5. doi: 58103.
  49. Rostami K, Steegers EA, Wong WY, Braat DD, Steegers-Theunissen RP. Coeliac disease and reproductive disorders: a neglected association. Eur J Obstet Gynecol Reprod Biol. 2001;96(2):146-9.
  50. Быкова СВ, Сабельникова ЕА, Парфенов АИ, Гудкова РБ, Крумс ЛМ, Чикунова БЗ. Репродуктивные расстройства у женщин с це-лиакией. Влияние этиотропной терапии. Экспериментальная клиническая гастроэнтерология. 2011;(3):12-8.
  51. Быкова СВ, Парфенов АИ, Тетруашвили НК, Сабельникова ЕА, Гудкова РБ, Крумс ЛМ, Воробьева НН, Репина ЕА, Витязева ИН, Петухова ГС. Распространенность глютен-чувствительной целиакии у женщин с нарушением репродуктивной функции. Терапевтический архив. 2012;83(2):31-5.
  52. Tursi A, Giorgetti G, Brandimarte G, Elisei W. Effect of gluten-free diet on pregnancy outcome in celiac disease patients with recurrent miscarriages. Dig Dis Sci. 2008;53(11):2925-8. doi: 10.1007/s10620-008-0242-x.
  53. Gillett PM, Gillett HR, Israel DM, Metzger DL, Stewart L, Chanoine JP, Freeman HJ. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysi-um and tissue transglutaminase. Can J Gastroenterol. 2001;15(5):297-301.
  54. Holmes GK. Screening for coeliac disease in type 1 diabetes. Arch Dis Child. 2002;87(6): 495-8.
  55. Mollazadegan K, Kugelberg M, Montgomery SM, Sanders DS, Ludvigsson J, Ludvigs-son JF. A population-based study of the risk of diabetic retinopathy in patients with type 1 diabetes and celiac disease. Diabetes Care. 2013;36(2):316-21. doi: 10.2337/dc12-0766.
  56. Leeds JS, Hopper AD, Hadjivassiliou M, Tes-faye S, Sanders DS. High prevalence of micro-vascular complications in adults with type 1 diabetes and newly diagnosed celiac disease. Diabetes Care. 2011;34(10):2158-63. doi: 10.2337/dc11-0149.
  57. Cohn A, Sofia AM, Kupfer SS. Type 1 diabetes and celiac disease: clinical overlap and new insights into disease pathogenesis. Current diabetes reports. 2014;14(8):517. doi: 10.1007/ s11892-014-0517-x.
  58. Elfstrom P, Sundstrom J, Ludvigsson JF. Systematic review with meta-analysis: associations between coeliac disease and type 1 diabetes. Aliment Pharmacol Ther. 2014;40(10):1123-32. doi: 10.1111/apt.12973.
  59. Kuitinen P, Maenpua J, Krohn K, Viskorpi JK. Gastrointestinal findings in autoimmune thy-roiditis and non-goitrous juvenile hypothy-roidism in children. Scand J Gastroenterol. 1971;6(4):336-41.
  60. Barker JM, Liu E. Celiac disease: pathophys-iology, clinical manifestations, and associated autoimmune conditions. Adv Pediatr. 2008;55:349-65.
  61. Larizza D, Calcaterra V, De Giacomo C, De Silvestri A, Asti M, Badulli C, Autelli M, Coslovich E, Martinetti M. Celiac disease in children with autoimmune thyroid disease. J Pediatr. 2001;139(5):738-40. doi: 10.1067/mpd.2001.118189.
  62. Ching CL, Jones MK, Kingham JG. Celiac disease and autoimmune thyroid disease. Clin Med Res. 2007;5(3):184-92. doi: 10.3121/ cmr.2007.738.
  63. Sari S, Yesilkaya E, Egritas O, Bideci A, Dalgic B. Prevalence of celiac disease in Turkish children with autoimmune thyroiditis. Dig Dis Sci. 2009;54(4):830-2. doi: 10.1007/s10620-008-0437-1.
  64. Парфенов АИ. Болезни кожи и целиакия. Дерматология. Приложение к журналу Con-silium Medicum. 2009;(1):51-6.
  65. Rose C, Armbruster FP, Ruppert J, Igl BW, Zillik-ens D, Shimanovich I. Autoantibodies against epidermal transglutaminase are sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet. J Amer Acadev Dermatol. 2009;61(1):39-43. doi: 10.1016/j.jaad.2008.
  66. Stamnaes J, Dorum S, Fleckenstein B, Aeschli-mann D, Sollid LM. Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia. Amino Acids. 2010;39(5):1183-91. doi: 10.1007/s00726-010-0554-y.
  67. Rubio-Tapia A, Van Dyke CT, Lahr BD, Zins-meister AR, El-Youssef M, Moore SB, Bowman M, Burgart LJ, Melton LJ 3rd, Murray JA. Predictors of family risk for celiac disease: a population-based study. Clin Gastroenterol Hepatol. 2008;6(9):983-7. doi: 10.1016/j.cgh.2008.04.008.
  68. Fasano A, Berti I, Gerarduzzi T, Not T, Collet-ti RB, Drago S, Elitsur Y, Green PH, Guanda-lini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163(3):286-92.
  69. Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Am J Gastroenterol. 2003;98(2):377-81. doi: 10.1111/j.1572-0241.2003.07238.x.
  70. Murray JA. Celiac disease in patients with an affected member, type 1 diabetes, iron-deficiency, or osteoporosis? Gastroenterology. 2005;128(4 Suppl 1):S52-6.
  71. Kinos S, Kurppa K, Ukkola A, Collin P, Lah-deaho ML, Huhtala H, Kekkonen L, Maki M, Kauk-inen K. Burden of illness in screen-detected children with celiac disease and their families. J Pediatr Gastroenterol Nutr. 2012;55(4):412-6. doi: 10.1097/MPG.0b013e31825f18ff.
  72. Van der Windt DA, Jellema P, Mulder CJ, Kneepkens CM, van der Horst HE. Diagnostic testing forceliac disease among patients with abdominal symptoms: a systematic review. JAMA. 2010;303(17):1738-46. doi: 10.1001/jama.2010.549.
  73. McNeish AS, Harms HK, Rey J, Shmerling DH, Visakorpi JK, Walker-Smith JA. The diagnosis of coeliac disease. A commentary on the current practices of members of the European Society for Paediatric Gastroenterology and Nutrition(ESPGAN). Arch Dis Child. 1979;54(10):783-6.
  74. Molberg O, McAdam SN, Korner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Noren O, Roepstorff P, Lundin KE, Sjostrom H, Sollid LM. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med. 1998;4(6):713-7.
  75. Villalta D, Tonutti E, Prause C, Koletzko S, Uh-lig HH, Vermeersch P, Bossuyt X, Stern M, Laass MW, Ellis JH, Ciclitira PJ, Richter T, Daehn-rich C, Schlumberger W, Mothes T. IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency. Clin Chem. 2010;56(3):464-8. doi: 10.1373/clinchem.2009.128132.
  76. Li M, Yu L, Tiberti C, Bonamico M, Taki I, Miao D, Murray JA, Rewers MJ, Hoffenberg EJ, Agardh D, Mueller P, Stern M, Bonifacio E, Liu E. A report on the International Transglutami-nase Autoantibody Workshop for Celiac Disease. Am J Gastroenterol. 2009;104(1):154-63. doi: 10.1038/ajg.2008.8.
  77. Sollid LM, Lie BA. Celiac disease genetics: current concepts and practical applications. Clin Gastroenterol Hepatol. 2005;3(9):843-51.
  78. Van de Wal Y, Kooy YM, van Veelen PA, Pena SA, Mearin LM, Molberg O, Lundin KE, Sollid LM, Mutis T, Benckhuijsen WE, Drijfhout JW, Kon-ing F. Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. Proc Natl Acad Sci U S A. 1998;95(17):10050-4.
  79. Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglu-taminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther. 2010;31(1):73-81. doi: 10.1111/j.1365-2036.2009.04110.x.
  80. Husby S, Koletzko S, Korponay-Szabo IR, Mear-in ML, Phillips A, Shamir R, Troncone R, Gier-siepen K, Branski D, Catassi C, Lelgeman M, Maki M, Ribes-Koninckx C, Ventura A, Zim-mer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterolo-gy Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenter-ology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54(1):136-60. doi: 10.1097/MPG.0b013e31821a23d0.
  81. Vokhmyanina NV. Algoritm laboratornogo monitoringa bol'nykh tseliakiey: Avtoref. diss. ... kand. med. nauk [Algorithm for laboratory monitoring of coeliac disease patients. Thesis for Doctoral Degree in Medicine]. Saint Petersburg; 2002 (in Russian).
  82. AGA Institute. AGA Institute medical position statement on the diagnosis and management of celiac disease. Gastroenterology. 2006;131(6):1977-80. doi: 10.1053/j. gastro.2006.10.003.
  83. Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciac-ci C, Ciclitira PJ, Green PH, Hadjivassiliou M, Holdoway A, van Heel DA, Kaukinen K, Lef-fler DA, Leonard JN, Lundin KE, McGough N, Davidson M, Murray JA, Swift GL, Walker MM, Zingone F, Sanders DS, et al. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014;63(8):1210-28. doi: 10.1136/gutjnl-2013-306578.
  84. Dahlbom I, Olsson M, Forooz NK, Sjoholm AG, Truedsson L, Hansson T. Immunoglobulin G (IgG) anti-tissue transglutaminase antibodies used as markers for IgA-deficient celiac disease patients. Clin Diagn Lab Immunol. 2005;12(2):254-8. doi: 10.1128/CDLI.12.2.254-258.2005.
  85. Collin P, Kaukinen K, Vogelsang H, Korponay-Szabo I, Sommer R, Schreier E, Volta U, Granito A, Veronesi L, Mascart F, Ocmant A, Ivarsson A, Lagerqvist C, Burgin-Wolff A, Hadziselimovic F, Furlano RI, Sidler MA, Mulder CJ, Goerres MS, Mearin ML, Ninaber MK, Gudmand-H0yer E, Fabiani E, Catassi C, Tidlund H, Alainentalo L, Maki M. Antiendomysial and antihuman re-combinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study. Eur J Gastroenterol Hepatol. 2005;17(1):85-91.
  86. Giorgio F, Principi M, Losurdo G, Piscitelli D, Iannone A, Barone M, Amoruso A, Ierar-di E, Di Leo A. Seronegative Celiac Disease and Immunoglobulin Deficiency: Where to Look in the Submerged Iceberg? Nutrients. 2015;7(9):7486-504. doi: 10.3390/nu7095350. Available from: http://www.researchgate.net/ publication/281813695.
  87. Jabri B, Sollid LM. Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol. 2009;9(12):858-70. doi: 10.1038/nri2670.
  88. Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009;373 (9673):1480-93. doi: 10.1016/S0140-6736(09)60254-3.
  89. Marsh MN. Mucosal pathology in gluten sensitivity. In: Michael N Marsh, editor. Coeliac Disease. Oxford: Blackwell Scientific Publications; 1992. p. 136-91.
  90. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for patholo-gists. Eur J Gastroenterol Hepatol. 1999;11(10): 1185-94.
  91. Akram S, Murray JA, Pardi DS, Alexander GL, Schaffner JA, Russo PA, Abraham SC. Adult autoimmune enteropathy: Mayo Clinic Rochester experience. Clin Gastroenterol Hepatol. 2007;5(11):1282-90. doi: 10.1016/j.cgh.2007.05.013.
  92. Jarvinen TT, Collin P, Rasmussen M, Kyronpa-lo S, Maki M, Partanen J, Reunala T, Kaukin-en K. Villous tip intraepithelial lymphocytes as markers of early-stage coeliac disease. Scand J Gastroenterol. 2004;39(5):428-33.
  93. Bai J, Zeballos E, Fried M, Corazza GR, Schup-pan D, Farthing MJG, Catassi C, Greco L, Cohen H, Krabshuis J.H. WGO Practice Guideline Celiac Disease. Available from: http:// www.worldgastroenterology.org/UserFiles/ file/guidelines/celiac-disease-english-2005. pdf.
  94. Margaritte-Jeannin P, Babron MC, Bourgey M, Louka AS, Clot F, Percopo S, Coto I, Hu-got JP, Ascher H, Sollid LM, Greco L, Cler-get-Darpoux F. HLA-DQ relative risks for coe-liac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease. Tissue Antigens. 2004;63(6):562-7. doi: 10.1111/j.0001-2815.2004.00237.x.
  95. Spurkland A, Sollid LM, Polanco I, Vartdal F, Thorsby E. HLA-DR and -DQ genotypes of ce-liac disease patients serologically typed to be non-DR3 or non-DR5/7. Hum Immunol. 1992;35(3):188-92.
  96. Leffler DA, Dennis M, Hyett B, Kelly E, Schup-pan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol. 2007;5(4):445-50. doi: 10.1016/j.cgh.2006.12.006.
  97. Abdulkarim AS, Burgart LJ, See J, Murray JA. Etiology of nonresponsive celiac disease: results of a systematic approach. Am J Gastroenterol. 2002;97(8):2016-21. doi: 10.1111/j.1572-0241.2002.05917.x.
  98. Van Gils T, Nijeboer P, van Wanrooij RL, Bou-ma G, Mulder CJ. Mechanisms and management of refractory coeliac disease. Nat Rev Gastroenterol Hepatol. 2015;12(10):572-9. doi: 10.1038/nrgastro.2015.155.
  99. O'Mahony S, Howdle PD, Losowsky MS. Review article: management of patients with nonre-sponsive coeliac disease. Aliment Pharmacol Ther. 1996;10(5):671-80.
  100. Fine KD, Meyer RL, Lee EL. The prevalence and causes of chronic diarrhea in patients with ce-liac sprue treated with a gluten-free diet. Gas-troenterology. 1997;112(6):1830-8.
  101. Daum S, Cellier C, Mulder CJ. Refractory coeliac disease. Best Pract Res Clin Gastroenterol. 2005;19(3):413-24. doi: 10.1016/j.bpg.2005.02.001.
  102. Daum S, Ipczynski R, Schumann M, Wahn-schaffe U, Zeitz M, Ullrich R. High rates of complications and substantial mortality in both types of refractory sprue. Eur J Gastroenterol Hepatol. 2009;21(1):66-70. doi: 10.1097/MEG. 0b013e328307c20c.
  103. Al-Toma A, Verbeek WH, Mulder CJ. The management of complicated celiac disease. Dig Dis. 2007;25(3):230-6. doi: 10.1159/000103891.
  104. Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ. Survival in refractory coeliac disease and enterop-athy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut. 2007;56(10):1373-8. doi: 10.1136/gut.2006.114512.
  105. Malamut G, Afchain P, Verkarre V, Lecom-te T, Amiot A, Damotte D, Bouhnik Y, Co-lombel JF, Delchier JC, Allez M, Cosnes J, Lavergne-Slove A, Meresse B, Trinquart L, Mac-intyre E, Radford-Weiss I, Hermine O, Brousse N, Cerf-Bensussan N, Cellier C. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology. 2009;136(1):81-90. doi: 10.1053/j.gastro.2008.09.069.
  106. Rubio-Tapia A, Kelly DG, Lahr BD, Dogan A, Wu TT, Murray JA. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology. 2009;136(1):99-107. doi: 10.1053/j.gastro.2008.10.013.
  107. Culliford A, Daly J, Diamond B, Rubin M, Green PH. The value of wireless capsule endos-copy in patients with complicated celiac disease. Gastrointest Endosc. 2005;62(1):55-61.
  108. Daum S, Wahnschaffe U, Glasenapp R, Borchert M, Ullrich R, Zeitz M, Faiss S. Capsule endoscopy in refractory celiac disease. Endoscopy. 2007;39(5):455-8. doi: 10.1055/s-2007-966239.
  109. Hadithi M, Al-Toma A, Oudejans J, van Bode-graven AA, Mulder CJ, Jacobs M. The value of double-balloon enteroscopy in patients with refractory celiac disease. Am J Gastroenterol. 2007;102(5):987-96. doi: 10.1111/j.1572-0241.2007.01122.x.
  110. Brar P, Lee S, Lewis S, Egbuna I, Bhagat G, Green PH. Budesonide in the treatment of refractory celiac disease. Am J Gastroenterol. 2007;102(10):2265-9. doi: 10.1111/j.1572-0241.2007.01380.x.
  111. Mallant M, Hadithi M, Al-Toma AB, Kater M, Jacobs M, Manoliu R, Mulder C, van Waesber-ghe JH. Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. World J Gastroenterol. 2007;13(11):1696-700.
  112. Hadithi M, Mallant M, Oudejans J, van Waes-berghe JH, Mulder CJ, Comans EF. 18F-FDG PET versus CT for the detection of enteropathy-as-sociated T-cell lymphoma in refractory celiac disease. J Nucl Med. 2006;47(10):1622-7.
  113. Cellier C, Delabesse E, Helmer C, Patey N, Matuchansky C, Jabri B, Macintyre E, Cerf-Ben-sussan N, Brousse N. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet. 2000;356(9225):203-8.
  114. Cellier C, Patey N, Mauvieux L, Jabri B, De-labesse E, Cervoni JP, Burtin ML, Guy-Grand D, Bouhnik Y, Modigliani R, Barbier JP, Mac-intyre E, Brousse N, Cerf-Bensussan N. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology. 1998;114(3):471-81.
  115. Daum S, Weiss D, Hummel M, Ullrich R, Heise W, Stein H, Riecken EO, Foss HD; Intestinal Lymphoma Study Group. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lym-phoma, coeliac disease, and refractory sprue. Gut. 2001;49(6):804-12.
  116. Maurino E, Niveloni S, Chernavsky AC, Sugai E, Vazquez H, Pedreira S, Periolo N, Mazure R, Smecuol E, Moreno ML, Litwin N, Nachman F, Kogan Z, Bai JC. Clinical characteristics and long-term outcome of patients with refractory sprue diagnosed at a single institution. Acta Gastroenterol Latinoam. 2006;36(1):10-22.
  117. See J, Murray JA. Gluten-free diet: the medical and nutrition management of celiac disease. Nutr Clin Pract. 2006;21(1):1-15.
  118. Goerres MS, Meijer JW, Wahab PJ, Ker-ckhaert JA, Groenen PJ, Van Krieken JH, Mulder CJ. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment Pharmacol Ther. 2003;18(5):487-94.
  119. Daum S, Ipczynski R, Heine B, Schulzke JD, Zeitz M, Ullrich R. Therapy with budesonide in patients with refractory sprue. Digestion. 2006;73(1):60-8. doi: 10.1159/000092639.
  120. Wahab PJ, Crusius JB, Meijer JW, Uil JJ, Mulder CJ. Cyclosporin in the treatment of adults with refractory coeliac disease-an open pilot study. Aliment Pharmacol Ther. 2000;14(6):767-74.
  121. Gillett HR, Arnott ID, McIntyre M, Campbell S, Dahele A, Priest M, Jackson R, Ghosh S. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology. 2002;122(3):800-5.
  122. Vivas S, Ruiz de Morales JM, Ramos F, Su-arez-Vilela D. Alemtuzumab for refractory celiac disease in a patient at risk for enterop-athy-associated T-cell lymphoma. N Engl J Med. 2006;354(23):2514-5. doi: 10.1056/NE-JMc053129.
  123. Verbeek WH, Mulder CJ, Zweegman S. Alemtu-zumab for refractory celiac disease. N Engl J Med. 2006;355(13):1396-7. doi: 10.1056/NE-JMc061784.
  124. Al-Toma A, Goerres MS, Meijer JW, von Blomberg BM, Wahab PJ, Kerckhaert JA, Mulder CJ. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin Gas-troenterol Hepatol. 2006;4(11):1322-7. doi: 10.1016/j.cgh.2006.07.007.
  125. Al-Toma A, Visser OJ, van Roessel HM, von Blomberg BM, Verbeek WH, Scholten PE, Ossenkoppele GJ, Huijgens PC, Mulder CJ. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells. Blood. 2007;109(5):2243-9. doi: 10.1182/blood-2006-08-042820.
  126. Cellier C, Cerf-Bensussan N. Treatment of clonal refractory celiac disease or cryptic intraepithelial lymphoma: A long road from bench to bedside. Clin Gastroenterol Hepatol. 2006;4(11):1320-1. doi: 10.1016/j cgh.2006.09.011.
  127. Федеральные клинические рекомендации по оказанию медицинской помощи детям с целиакией. М.; 2015. Доступно на: http://www.pediatr-russia.ru/sites/default/files/file/ kr_celik.pdf.
  128. Национальная программа оптимизации вскармливания детей первого года жизни в Российской Федерации. М.; 2011. с. 46-7.
  129. Рославцева ЕА. Дифференцирование диететики при синдроме мальабсорбции у детей раннего возраста: Автореф. дисс. ... Кандидат медицинских наук. М.; 1992.
  130. Крумс ЛМ, Сабельникова ЕА. Хронические болезни тонкой кишки (клиника, диагностика, лечение). М.; 2014. 95 c.
  131. Lebwohl B, Granath F, Ekbom A, Smedby KE, Murray JA, Neugut AI, Green PH, Ludvigs-son JF. Mucosal healing and risk for lymph-oproliferative malignancy in celiac disease: a population-based cohort study. Ann Intern Med. 2013;159(3):169-75. doi: 10.7326/00034819-159-3-201308060-00006.
  132. Bardella MT, Molteni N, Prampolini L, Giun-ta AM, Baldassarri AR, Morganti D, Bianchi PA. Need for follow up in coeliac disease. Arch Dis Child. 1994;70(3):211-3.
  133. Hutchinson JM, West NP, Robins GG, Howd-le PD. Long-term histological follow-up of people with coeliac disease in a UK teaching hospital. QJM. 2010;103(7):511-7. doi: 10.1093/qjmed/hcq076.
  134. Lanzini A, Lanzarotto F, Villanacci V, Mora A, Bertolazzi S, Turini D, Carella G, Malagoli A, Ferrante G, Cesana BM, Ricci C. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment Pharmacol Ther. 2009;29(12):1299-308. doi: 10.1111/j.1365-2036.2009.03992.x.
  135. Парфенов АИ. Глютенчувствительная цели-акия от диагноза к лечению. Русский медицинский журнал. 2007;15(6):458-64.
  136. Wahab PJ, Meijer JW, Mulder CJ. Histologic follow-up of people with celiac disease on a glutenfree diet: slow and incomplete recovery. Am J Clin Pathol. 2002;118(3):459-63. doi: 10.1309/EVXT-851X-WHLC-RLX9.
  137. Rubio-Tapia A, Rahim MW, See JA, Lahr BD, Wu TT, Murray JA. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am J Gastroenterol. 2010;105(6):1412-20. doi: 10.1038/ajg.2010.10.
  138. Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serolog-ical and symptomatic responses to gluten challenge in adults with coeliac disease. Gut. 2013;62(7):996-1004. doi: 10.1136/gut-jnl-2012-302196.
  139. Kaukinen K, Peraaho M, Lindfors K, Partanen J, Woolley N, Pikkarainen P, Karvonen AL, Laas-anen T, Sievanen H, Maki M, Collin P. Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease. Aliment Pharmacol Ther. 2007;25(10):1237-45. doi: 10.1111/j.1365-2036.2007.03311.x.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2016 article E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies