Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

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Abstract

Aims: 1) To evaluate an association between the fat fraction (FF) and bone mineral density (BMD) measured by localized proton magnetic resonance spectroscopy (1H-MRS) and quantitative computed tomography (QCT) densitometry, respectively, in healthy vertebrae of children after a compression fracture; 2) To compare the FF and BMD values with the severity of the compression vertebrae fractures.

Materials and methods: Twenty (20) patients (aged 11.1±2.1 years) with a trauma-induced compression vertebral fractures participated in the study. The BMD of L3, L4 vertebrae (mg/cm3) was measured in by QCT (Philips Brilliance 16). FF in the same area was measured from 1H-MR-spectra (STEAM, echo time (TE)=12.8 ms, repetition time (TR)=3000 ms, voxel size=20×15×10 mm) using Philips Achieva TX 3.0T MRI scanner.

Results: Correlation analysis revealed a  significant inverse linear correlation (r=-0.55, p=0.0004) between FF and BMD of L3 и L4 vertebrae. In addition, in the patients with severe compression vertebral fracture (more than 2 fractured vertebrae) there was a  significant increase in FF values and a  BMD decrease, compared to the values in the patients with mild fractures (1–2 fractured vertebrae).

Conclusion: The correlation suggests that the increase of FF in the bone marrow and the decrease of BMD in children go in parallel. Therefore, 1H-MRS could be an alternative to QCT and dual-energy X-ray absorptiometry. The absence of radiation load allows for recommendation to use 1Н-MRS for screening and follow-up, as well as for the control of BMD.

About the authors

A. S. Ivantsova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Anna S. Ivantsova – Junior Research Fellow, Postgraduate Student 

22 Bol'shaya Polyanka ul., Moscow, 119180

Россия

P. E. Menshchikov

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences;
Philips Healthcare LLC

Author for correspondence.
Email: petr.menshchikov@philips.com

Petr E. Menshchikov – PhD (in Phys. and Math.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Junior Research Fellow N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences; Scientific Projects Support Specialist Philips Healthcare LLC

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991;
13 Sergeya Makeeva ul., Moscow, 123022

Россия

U. A. Polyakova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Ul'yana A. Polyakova – Radiologist, Department of Radiological Methods 

22 Bol'shaya Polyanka ul., Moscow, 119180

Россия

A. V. Manzhurtsev

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru

Andrey V. Manzhurtsev – PhD (in Phys. and Math.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Junior Research Fellow, Laboratory of Kinetics and Mechanisms of Enzymatic and Catalytic Reactions Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991

Россия

M. V. Ublinskiy

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru
ORCID iD: 0000-0002-4627-9874

Maxim V. Ublinskiy – PhD (in Biol.), Research Fellow, Department of Radiological Methods Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Research Fellow Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991

Россия

T. A. Akhadov

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma

Email: fake@neicon.ru

Tolibdzhon A. Akhadov – MD, PhD, Professor, Head of Department of Radiological Methods 

22 Bol'shaya Polyanka ul., Moscow, 119180

Россия

D. A. Kupriyanov

Philips Healthcare LLC

Email: fake@neicon.ru

Dmitriy A. Kupriyanov – PhD (in Phys. and Math.), Scientific Projects Support Senior Specialist

13 Sergeya Makeeva ul., Moscow, 123022

Россия

N. A. Semenova

Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences;
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

Email: fake@neicon.ru

Nataliya A. Semenova – Doctor of Biol. Sci., Chief Research Fellow Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; Research Fellow N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences; Chief Research Fellow Emanuel Institute of Biochemical Physics of Russian Academy of Sciences

22 Bol'shaya Polyanka ul., Moscow, 119180;
4 Kosygina ul., Moscow, 119991;
4 Kosygina ul., Moscow, 119334

Россия

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Copyright (c) 2021 Ivantsova A.S., Menshchikov P.E., Polyakova U.A., Manzhurtsev A.V., Ublinskiy M.V., Akhadov T.A., Kupriyanov D.A., Semenova N.A.

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