Liver transplantation in the Novosibirsk Region: evolution of the program and its outcomes

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Abstract

Objective: To assess early and late outcomes of the orthotopic liver transplantation (LTx) program in the Novosibirsk Region from August 2010 to June 2018.

Materials and methods: This retrospective study included 176 patients aged 41.5 ± 16.69 years (from 5 months to 69 years; median 44 years), who underwent 185 LTx procedures including nine retransplantations.

Results: Some particulars of vascular and biliary reconstruction in various LTx types are discussed. The incidence of vascular and biliary complications was 1.6% and 10.3%, respectively. The duration of stay in the intensive care unit was 7 ± 7.1 days (from 0 to 69 days, median 5) and mean total duration of hospital stay was 33 ± 18.1 days (from 1 to 136 days, median 30). Early graft dysfunction was observed in 28 (15.9%) of the recipients. Perioperative (up to 90 days) mortality was 4.5% (8 recipients, including one intra-operative death). There was zero mortality in the liver fragment recipients. The overall 5-year patient and graft survival rates were 71% and 65%, respectively.

Conclusion: The Novosibirsk Region has a well-established LTx program, with its outcomes being comparable to those of the leading Russian centers and large worldwide registries. In 2017, LTx prevalence was 12.9 per million of the population. Thus, the region has become one of the most provided with this type of medical care in the Russian Federation.

About the authors

I. A. Porshennikov

State Novosibirsk Regional Clinical Hospital; Novosibirsk State Medical University

Author for correspondence.
Email: porshennikov@oblmed.nsk.ru

Ivan A. Porshennikov – MD, PhD, Deputy Chief for Surgery SNRCH; Associate Professor, Chair of Hospital and Pediatric Surgery NSMU.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087, tel.: +7 (383) 315 96 76

Russian Federation

V. N. Pavlik

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Vladimir N. Pavlik – MD, Surgeon, Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

E. E. Shchekina

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Elena E. Shchekina – MD, Surgeon, Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

A. S. Kartashov

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Aleksey S. Kartashov – MD, Surgeon, Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

M. A. Korobeinikova

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Mariya A. Korobeinikova – MD, Surgeon, Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

E. G. Yushina

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Ekaterina G. Yushina – MD, Surgeon, Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

A. Yu. Bykov

State Novosibirsk Regional Clinical Hospital

Email: fake@neicon.ru

Aleksandr Yu. Bykov – MD, Head of Organ Transplantation Department.

130 Nemirovicha-Danchenko ul., Novosibirsk, 630087

Russian Federation

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Copyright (c) 2018 Porshennikov I.A., Pavlik V.N., Shchekina E.E., Kartashov A.S., Korobeinikova M.A., Yushina E.G., Bykov A.Y.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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