Wollfian tumor: a case report and a literature review

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Abstract

Wolffian tumor is a rare neoplasm arising from mesonephric duct remnants. Not more than 100 cases of the disease have been described. The authors present their own clinical observation of the Wolffian tumor in a 43-year old female patient. Radiological examinations resulted in the suspicion of a subserous leiomyoma of the uterus; however, the surgery showed a mass arising from the fallopian tube wall. Histologically, there was a growing tumor within the fallopian tube wall with no mucosal lesions. The tumor consisted of myxomatous stroma with cribriform, solid and reticular areas composed of relatively monomorphic, mildly eosinophilic cells with monotonous nuclei and single mitoses. On immunohistochemistry, the tumor cells expressed vimentin, pan-cytokeratin, cytokeratin 7 and calretinin. This case illustrates that final verification and differential diagnosis of the tumor with other fallopian tube neoplasms, including malignancies, is only possible with an immunohistochemical study.

About the authors

E. A. Dubova

Russian State Research Center – Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency

Author for correspondence.
Email: dubovaea@gmail.com

Elena A. Dubova – MD, PhD, Pathologist, Department of Pathology 

46 Zhivopisnaya ul., Moscow, 123182

Russian Federation

К. A. Pavlov

Russian State Research Center – Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency

Email: fake@neicon.ru

Konstantin A. Pavlov – MD, PhD, Pathologist, Department of Pathology 

46 Zhivopisnaya ul., Moscow, 123182

Russian Federation

S. V. Lishchuk

Russian State Research Center – Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency

Email: fake@neicon.ru

Sergey V. Lishchuk – MD, Head of Department of Pathology 

46 Zhivopisnaya ul., Moscow, 123182

Russian Federation

A. S. Tertychnyi

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

Alexander S. Tertychnyi – MD, PhD, Professor, A.I. Strukov Department of Pathology

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation

A. A. Bakhvalova

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

Alla A. Bakhvalova – MD, PhD, Gynecologist, Department of Obstetrics and Gynecology, V.F. Snegirev Clinic of Obstetrics and Gynecology 

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation

D. V. Bryunin

I.M. Sechenov First Moscow State Medical University

Email: fake@neicon.ru

Dmitriy V. Bryunin – MD, PhD, Professor, Head of Department of Obstetrics and Gynecology, V.F. Snegirev Clinic of Obstetrics and Gynecology

8/2 Trubetskaya ul., Moscow, 119991

Russian Federation

References

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  2. Heatley MK. Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature. Pathology. 2009;41(7): 645–8. doi: 10.3109/00313020903273084.
  3. Turkcapar AF, Seckin B, Gungor T, Sirvan L, Mollamahmutoğlu L. Diagnosis and management of female adnexal tumor of probable Wolffian origin (FATWO) arising from ovary: a case report. J Turk Ger Gynecol Assoc. 2013;14(1): 56–9. doi: 10.5152/jtgga.2013.14.
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  7. Tipps AM, Plaxe SC, Weidner N. Endometrioid carcinoma with a low-grade spindle cell component: a tumor resembling an adnexal tumor of probable Wolffian origin. Ann Diagn Pathol. 2011;15(5): 376–81. doi: 10.1016/j.anndiagpath.2010.06.004.
  8. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29(2): 143–56. doi: 10.1097/01. pas.0000149692.21205.9c.
  9. Czernobilsky B, Lifschitz-Mercer B, Trejo L, Atlas I. Granulosa cell tumor of the broad ligament: report of a case with emphasis on the differential diagnosis with female adnexal tumor of probable Wolffian origin. Int J Surg Pathol. 2011;19(6): 783–6. doi: 10.1177/1066896909356104.
  10. Lesin J, Forko-Ilić J, Plavec A, Planinić P. Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet. 2009;280(5): 855–7. doi: 10.1007/s00404-0091024-1.

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Copyright (c) 2018 Dubova E.A., Pavlov К.A., Lishchuk S.V., Tertychnyi A.S., Bakhvalova A.A., Bryunin D.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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