Guillain-Barré syndrome in a child: a clinical case

Cover Page

Cite item


Guillain-Barré syndrome is an orphan autoimmune disease associated with the involvement of the peripheral nervous system. The clinical course of the syndrome has four main types. We present a clinical case of Guillain-Barré syndrome in a 6-year old child. Against the background of a previous infection, he developed oculomotor dysfunction, peripheral tetraparesis, sensory abnormalities with subsequent severe weakness of the respiratory muscles. The differential diagnosis included inflammatory, infectious and neoplastic spinal cord disorders, spinal cord magnetic resonance imaging, and examination of the cerebrospinal fluid. The patient's electromyographic data confirmed peripheral nerve damage. Based on all of these, the patient was diagnosed with Guillain-Barré syndrome. Specific treatment, including plasmapheresis and intravenous human immunoglobulin G at a dose of 0.4 mg daily for 5 days, and symptomatic treatment resulted in gradual improvement and complete regression of the neurological symptoms completely resolved. Since Guillain-Barré syndrome is a rare disease of the peripheral nervous system, the awareness of the specifics of its clinical course allows for earlier correct diagnosis and effective treatment.

About the authors

A. Yu. Ryabchenko

Orenburg State Medical University

Author for correspondence.
ORCID iD: 0000-0001-8731-2565

Aleksandr Yu. Ryabchenko – MD, PhD, Associate Professor, Chair of Neurology, Medical Genetics

2/11–173 Ural’skaya ul., Orenburg, 460001

Tel.: +7 (912) 849 78 66

Russian Federation

E. V. Grankin

Regional Children's Clinical Hospital


Egor V. Grankin – Head of Department of Neurology

3 Rybakovskaya ul., Orenburg, 460006

Russian Federation


  1. Величко ИА, Барабанова МА. Синдром Гийена – Барре как актуальная проблема неврологии (обзор литературы). Кубанский научный медицинский вестник. 2019;26(2): 150–61. doi: 10.25207/1608-6228-2019-26-2-150-161.
  2. Супонева НА, Шакарян АК, Рахтеенко АВ, Пирадов МА, Митрофанова ИВ, Прыткова МИ, Леонтьева ИЯ, Шахгильдян СВ, Морозова НС. Клинико-лабораторные характеристики, лечение и прогноз синдрома Гийена-Барре у детей. Детские инфекции. 2015;14(3): 17–26. doi: 10.22627/2072-8107-2015-14-3-17-26.
  3. Войтенков ВБ, Климкин АВ, Скрипченко НВ. Дифференциальная диагностика аксональных и демиелинизирующих вариантов синдрома Гийена-Барре у детей. Неврологический журнал. 2017;22(3): 126–30. doi. 10.18821/1560-9545-2017-22-3-126-130.
  4. Ситкали ИВ, Колоколов ОВ. Синдром Гийена-Барре как междисциплинарная проблема. Лечащий врач. 2019;(11): 48–55. doi: 10.26295/OS.2019.59.53.012.
  5. Khiri N, Lazreg M, Bkiyar H, Diyas S, Housni B. [Miller Fischer syndrome: about a paediatric case]. Pan Afr Med J. 2018;30:37. French. doi: 10.11604/pamj.2018.30.37.14136.
  6. Puma A, Benoit J, Sacconi S, Uncini A. Miller Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain-Barré syndrome overlap with persistent non-demyelinating conduction blocks: a case report. BMC Neurol. 2018;18(1): 101. doi: 10.1186/s12883-018-1104-6.
  7. Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC. Diagnosis and management of Guillain-Barré syndrome in ten steps. Nat Rev Neurol. 2019;15(11): 671–683. doi: 10.1038/s41582-019-0250-9.
  8. Korinthenberg R, Trollmann R, Felderhoff-Müser U, Bernert G, Hackenberg A, Hufnagel M, Pohl M, Hahn G, Mentzel HJ, Sommer C, Lambeck J, Mecher F, Hessenauer M, Winterholler C, Kempf U, Jacobs BC, Rostasy K, Müller-Felber W. Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidenceand consensus-based guideline. Eur J Paediatr Neurol. 2020;25:5–16. doi: 10.1016/j.ejpn.2020.01.003.
  9. Verboon C, Doets AY, Galassi G, Davidson A, Waheed W, Péréon Y, Shahrizaila N, Kusunoki S, Lehmann HC, Harbo T, Monges S, Van den Bergh P, Willison HJ, Cornblath DR, Jacobs BC; IGOS Consortium. Current treatment practice of Guillain-Barré syndrome. Neurology. 2019;93(1):e59–76. doi: 10.1212/WNL.0000000000007719.

Copyright (c) 2020 Ryabchenko A.Y., Grankin E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies