Early administration of genetically engineered biological agents for immune-mediated inflammatory diseases: opportunities and prospects. An experts’ opinion

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Abstract

Psoriasis (Ps), psoriatic arthritis (PsA), and inflammatory bowel diseases (IBDs) are characterized by a  progressive course and commonly result in disability. Therefore, their early diagnosis with the assessment of a  clinical phenotype and unfavorable prognostic factors and the timely initiation of therapy are important. The paper provides the expert consensus on the definition of the early stage of Ps, PsA, and IBDs, their treatment goals and main unfavorable prognostic factors. It also gives the rationale for the early use of biological agents in patients with immune-mediated inflammatory diseases.

About the authors

D. I. Abdulganieva

Kazan Medical University

Author for correspondence.
Email: diana_s@mail.ru
ORCID iD: 0000-0001-7069-2725

Diana I. Abdulganieva – MD, PhD, Professor, Head of Chair of Hospital Therapy 

49 Butlerova ul., Kazan, Republic of Tatarstan, 420012

Russian Federation

A. L. Bakulev

V.I. Razumovsky Saratov State Medical University

Email: fake@neicon.ru
ORCID iD: 0000-0002-1450-4942

Andrey L. Bakulev – MD, PhD, Professor, Chair of Dermatovenereology and Cosmetology 

112 Bol'shaya Kazach'ya ul., Saratov, Saratovskaya oblast', Privolzhskiy federal'nyy okrug, 410012

Russian Federation

E. A. Belousova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: eabelous@yandex.ru
ORCID iD: 0000-0003-4523-3337

Elena A. Belousova – MD, PhD, Professor, Head of Department of Gastroenterology; Head of Chair of Gastroenterology, Postgraduate Training Faculty 

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

A. V. Veselov

National Medical Research Centre for Coloproctology named after A.N. Ryzhikh

Email: fake@neicon.ru
ORCID iD: 0000-0003-3115-1787

Alexey V. Veselov – Head of Department of Organization, Education and Development of Coloproctological Service 

2 Salyama Adilya ul., Moscow, 123423

Russian Federation

T. V. Korotaeva

Research Institute of Rheumatology named after V.A. Nasonova

Email: tatianakorotaeva@gmail.com
ORCID iD: 0000-0003-0579-1131

Tatiana V. Korotaeva – MD, PhD, Leading Research Fellow, Laboratory of Innovative Methods for Diagnosis and Treatment of Psoriatic Arthritis 

34A Kashirskoe shosse, Moscow, 115522

Russian Federation

A. M. Lila

Research Institute of Rheumatology named after V.A. Nasonova;
Russian Medical Academy of Continuous Professional Education

Email: fake@neicon.ru
ORCID iD: 0000-0002-6068-3080

Aleksander M. Lila – MD, PhD, Professor, Director Research Institute of Rheumatology named after V.A. Nasonova; Head of Chair of Rheumatology Russian Medical Academy of Continuous Professional Education

34A Kashirskoe shosse, Moscow, 115522; 
2/1–1 Barrikadnaya ul., Moscow, 125993

Russian Federation

E. Yu. Loginova

Research Institute of Rheumatology named after V.A. Nasonova

Email: fake@neicon.ru
ORCID iD: 0000-0001-6875-4552

Elena Yu. Loginova – MD, PhD, Senior Research Fellow, Laboratory of Spondylarthritis and Psoriatic Arthritis 

34A Kashirskoe shosse, Moscow, 115522

Russian Federation

E. V. Sokolovskiy

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: fake@neicon.ru
ORCID iD: 0000-0001-7610-6061

Evgeny V. Sokolovskiy – MD, PhD, Professor, Head of Chair and Clinic of Dermatovenereology 

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Russian Federation

M. M. Khobeysh

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: mkhobeysh@yandex.ru
ORCID iD: 0000-0001-8670-7223

Marianna M. Khobeysh – MD, PhD, Associate Professor, Chair and Clinic of Dermatovenereology 

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Russian Federation

M. V. Shapina

National Medical Research Centre for Coloproctology named after A.N. Ryzhikh

Email: fake@neicon.ru
ORCID iD: 0000-0003-1172-6221

Marina V. Shapina – MD, PhD, Head of Department of Research in Inflammatory and Functional Bowel Disorders 

2 Salyama Adilya ul., Moscow, 123423

Russian Federation

O. B. Shchukina

City Clinical Hospital No. 31 (Saint Petersburg)

Email: fake@neicon.ru

Oksana B. Shchukina – MD, PhD, Head of Center of Inflammatory Bowel Disease 

3 Dinamo prospekt, Saint Petersburg, 197110

Russian Federation

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