Non-invasive assessment of skin microcirculation in patients with COVID-19: three clinical cases

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Abstract

Currently, there is enough data to suggest a significant role of microcirculation abnormalities in the pathophysiology of COVID-19. However, no clinical studies on noninvasive assessment of blood microcirculation in patients with the new coronavirus infection have been performed. We measured skin microcirculation by laser Doppler flowmetry in the thermal and inspiratory gasp tests in 3 patients with various courses of COVID-19. A decrease in the skin microcirculation reactivity was found in a patient with a more severe course of coronavirus infection. We believe that assessment of skin microcirculation could become a promising tool for the development of new diagnostic approaches and in future of new treatments for patients with coronavirus infection, as well as for identification of patient categories with a high risk of its severe course. Further studies are required to evaluate the clinical applicability of laser Doppler flowmetry for assessment of skin microcirculation in patients with COVID-19.

About the authors

P. A. Glazkova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: polinikul@mail.ru
ORCID iD: 0000-0002-8830-7503

Polina A. Glazkova - Research Fellow, Laboratory of Medical and Physical Research.

61/2-8 Shchepkina ul., Moscow, 129110, Tel.: +7 (495) 681 89 84

Russian Federation

D. A. Kulikov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0002-4273-8295

Dmitry A. Kulikov - MD, PhD, Academic Secretary, Associate Professor, Chair of Endocrinology, Postgraduate Training Faculty.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

D. A. Rogatkin

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0002-7755-308X

Dmitry A. Rogatkin -PhD (in Engineering), Head of Laboratory of Medical and Physical Research.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

O. R. Zhuravlev

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0002-8457-2537

Oleg R. Zhuravlev - Junior Research Fellow, Department of Hematology and Immunotherapy.

61/2 Shchepkina ul., Moscow, 129110 Russian Federation

G. G. Shekhyan

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0003-0442-644X

Grant G. Shekhyan - MD, PhD, Leading Research Fellow, Department of Cardiology; Professor, Chair of Internal Diseases, Postgraduate Training Faculty.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

А. A. Glazkov

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0001-6122-0638

Alexey A. Glazkov - Research Fellow, Laboratory of Medical and Physical Research.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

K. A. Kozlova

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0003-4146-930X

Ksenia A. Kozlova - Laboratory Technician, Department of Experimental and Clinical Research.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

S. A. Terpigorev

Moscow Regional Research and Clinical Institute (MONIKI)

Email: fake@neicon.ru
ORCID iD: 0000-0001-5444-5943

Stanislav A. Terpigorev - MD, PhD, Head of Department of Occupational Pathology and Medical Examination; Professor, Chair of Internal Diseases, Postgraduate Training Faculty.

61/2 Shchepkina ul., Moscow, 129110

Russian Federation

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Copyright (c) 2020 Glazkova P.A., Kulikov D.A., Rogatkin D.A., Zhuravlev O.R., Shekhyan G.G., Glazkov А.A., Kozlova K.A., Terpigorev S.A.

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