The pathological anatomy of alcoholic disease

Cover Page

Cite item


The problem of alcohol abuse is high on the agenda for the whole world both medically and socially. However, the fight against this disease is less than effective, mostly due to the fact that its solution has been left to psychiatrists and experts in narcology. They are making attempts to treat alcoholism, a disease which results from long-term, chronic alcohol intoxication and alcohol dependence. What is missed here is a long period of excessive use of hard drinks characterized by alcohol cravings with no alcohol dependence; this period is called “excessive alcohol consumption”. Based on the results of 1113 autopsies of patients aged 18 to 73 years who died at home or in a hospital, the authors propose the concept of the alcohol disease, whose pathogenesis consists of 3 stages: stage 1, episodic alcohol intoxication, stage 2, excessive alcohol drinking, and stage 3, alcoholism and its complications. The article describes the changes over time that can be found in the liver, vessels and other organs. The authors emphasize that the formation of Mallory bodies (auto-antigens), mainly in the stage of alcoholism, triggers an irreversible autoimmune inflammatory reaction explaining an extremely poor effect of alcoholism treatment. In this regard, excessive alcohol drinking is being suggested as a separate stage, which should be treated by internists.

About the authors

V. S. Paukov

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
ORCID iD: 0000-0002-2646-911X

Vyacheslav S. Paukov - MD, PhD, Professor, Department of Pathological Anatomy named after Academician A.I. Strukov.

8/1 Trubetskaya ul., Moscow, 119991;8/2 Trubetskaya ul., Moscow, 119991.

Tel.: +7 (495) 708 37 62

Russian Federation

Yu. A. Erokhin

Novomoskovsk City Clinical Hospital


Yuriy A. Erokhin - MD, PhD, Pathologist, Department of Pathological Anatomy.

39 Kalinina ul., Novomoskovsk, Tul'skaya oblast'.

Russian Federation


  1. Немцов АВ. Алкоголизм в России: история вопроса, современные тенденции. Журнал неврологии и психиатрии им. С.С. Корсакова. 2007;Прилож. 1:3–7.
  2. Немцов АВ, Терехин АТ. Размеры и диагностический состав алкогольной смертности в России. Наркология. 2007;6(12):29–36.
  3. Lingford-Hughes AR, Davies SJ, McIver S, Williams TM, Daglish MR, Nutt DJ. Addiction. Br Med Bull. 2003;65:209–22. doi: 10.1093/bmb/65.1.209.
  4. Лисицын ЮП, Сидоров ПИ. Алкоголизм. Медико-социальные аспекты. М.: Медицина; 1990. 528 с.
  5. Пауков ВС. Алкогольная болезнь. Архив патологии. 1994;56(1):38–45.
  6. Пауков ВС, Беляева НЮ, Воронина ТМ. Алкоголизм и алкогольная болезнь. Терапевтический архив. 2001;73(2):65–7.
  7. Пауков ВС, Ерохин ЮА. Патологическая анатомия пьянства и алкоголизма. Архив патологии. 2004;66(4):3–9.
  8. Тарасова ОИ, Огурцов ПП, Мазурчик НВ, Моисеев ВС. Современные лабораторные маркеры употребления алкоголя. Клиническая фармакология и терапия. 2007;16(1):10–5.
  9. Пауков ВС, Кириллов ЮА, Чернов ИА, Штемплевская ЕВ. Современный взгляд на тельца Мэллори. Клиническая и экспериментальная морфология. 2019;8(4):5–12. doi: 10.31088/CEM2019.8.4.5-12.
  10. Пауков ВС, Угрюмов АИ, Беляева НЮ. Межорганные отношения при алкогольной интоксикации. Архив патологии. 1991;53(3):3–11.
  11. Пауков ВС, Беляева НЮ. Палочковидные включения в сердце и головном мозге при экспериментальной алкоголизации крыс. Бюллетень экспериментальной биологии и медицины. 1985;100(7):100–3.
  12. Peng Y, French BA, Tillman B, Morgan TR, FrenchSW. The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. Exp Mol Pathol. 2014;97(2):305–13. doi: 10.1016/j.yexmp.2014.08.006.
  13. ShenH, FrenchBA, LiuH, TillmanBC, FrenchSW. Increased activity of the complement system in the liver of patients with alcoholic hepatitis. Exp Mol Pathol. 2014;97(3):338–44. doi: 10.1016/j.yexmp.2014.09.004.

Supplementary files

There are no supplementary files to display.

Copyright (c) 2020 Paukov V.S., Erokhin Y.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies