Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)9210.18786/2072-0505-2015-40-35-46АКТУАЛЬНАЯ ПРОБЛЕМАIMMUNOLOGICAL FUNCTION OF INTESTINAL MICROFLORA, ITS ABNORMALITIES AND POSSIBILITIES OF CORRECTIONИММУНОЛОГИЧЕСКАЯ ФУНКЦИЯ ИНТЕСТИНАЛЬНОЙ МИКРОФЛОРЫ, ЕЕ НАРУШЕНИЯ И ВОЗМОЖНОСТИ КОРРЕКЦИИUrsovaN. I.УрсоваН. И.
Russian Federation

Ursova Nataliya Igorevna – MD, PhD, Professor, Head of Department of Pediatrics; Head of Chair of Pediatrics, Postgraduate Training Faculty, Chief Pediatrician of the Ministry of Health of the Moscow Region

Урсова Наталия Игоревна –  доктор медицинских наук, профессор, руководитель педиатрического отделения, заведующая кафедрой педиатрии факультета усовершенствования врачей, главный педиатр Министерства здравоохранения Московской области

ursovan@mail.ruMoscow Regional Research and Clinical InstituteМосковский областной научно-исследовательский клинический институт имени М.Ф. Владимирского150820154035461202201612022016Copyright ©; 2015, Ursova N.I.Copyright ©; 2015, Урсова Н.И.2015Ursova N.I.Урсова Н.И.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/92

The review presents  current  data  indicating  that normal   microflora  plays  an  important  role  in the development of intestinal immune system. Intestinal microorganisms stimulate maturation of intestinal  lymphoid  tissue, synthesis  of secretory immunoglobulin A,  activate  phagocytosis, stimulate  the  cytokine and  interferon  system. Of interest is the discussion of tolerance  phenomenon which is highly significant for formation of a stable   micro-biocenosis. Probiotics are increasingly used for controlled  formation  or restoration  of abnormal micro-biocenosis. Confirmation of the useful properties  of every strain of a probiotic culture in controlled clinical trials is recognized as one of the key requirements to probiotics.

В обзоре представлены современные данные, свидетельствующие  о том, что нормальная  микрофлора  играет  важную роль  в развитии  иммунной системы кишечника. Интестинальные микроорганизмы  стимулируют созревание лимфоидного аппарата кишечника, синтез секреторного  иммуноглобулина  А, активизируют фагоцитоз,   стимулируют   систему   цитокинов и интерферонов. Представляет  интерес  обсуждение  информации  о  том, что  феномен  толерантности является наиболее значимым для создания   устойчивого   микробиоценоза.  Для   направленного формирования  или  восстановления нарушенного  микробиоценоза все шире применяют пробиотики. В качестве одного из ключевых требований  к пробиотикам  признано подтверждение полезных свойств каждого штамма пробиотической  культуры в контролируемых клинических исследованиях.

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