Almanac of Clinical MedicineAlmanac of Clinical Medicine2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)8410.18786/2072-0505-2015-41-97-102PULMONARY EMBOLISM: SOME ISSUES OF EPIDEMIOLOGY AND TREATMENT IN CANCER PATIENTSRozanovI. D.Rozanov Ivan Dmitrievich – Doctor, Department of Radiologyandreybalkanov@yandex.ruSemashkovaA. E.Semashkova Anna Evgen'evna – Junior Research Fellow, Internal Disease Department No. 1andreybalkanov@yandex.ruBalkanovA. S.Balkanov Andrey Sergeevich – MD, PhD, Head of Department of Radiologyandreybalkanov@yandex.ruTerpigorevS. A.Terpigorev Stanislav Anatol'evich – MD, PhD, Head of Department of Occupational Diseases and Medi cal and Labour Expertiseandreybalkanov@yandex.ruStepanovaE. A.Stepanova Elena Aleksandrovna – PhD, Roentgenologist, Department of X-ray Computed Tomography and Magnetic Resonance Imaging; Assistant Lecturer, Chair of Diagnostic Radiology, Postgraduate Training Facultyandreybalkanov@yandex.ruMoscow Regional Research and Clinical Institute1509201541971021202201612022016Copyright © 2015, Rozanov I.D., Semashkova A.E., Balkanov A.S., Terpigorev S.A., Stepanova E.A.2015The risk of pulmonary embolism (PE) in cancer patients is 4–7-fold, compared to other patient categories. PE is the second most frequent cause of death in the first year after cancer diagnosis. PE is diagnosed in 7.5% of patients with malignant brain tumors, in 1 to 25% of those with gastrointestinal tumors, in 4.5 to 17.5% of those with breast cancer and in 4 to 10% of lung cancer patients. The risk of PE is higher with surgical interventions and chemotherapy, as well as in metastatic tumors. In 13% of cases, PE may be the first symptom of cancer manifestation. For prevention and treatment of PE low molecular weight heparin (LMWH) and warfarin are used. The risk of recurrent PE is 2-fold lower with LMWH. The frequency of bleeding with LMWH and warfarin treatment is from 14 to 19%. Placement of a cava filter is indicated only if anticoagulation is inefficient. New oral anticoagulants, which act as selective thrombin or Factor Xa inhibitors, are not used in cancer patients. Thus, diagnostics and treatment of PE is a very urgent problem in oncology that requires new approaches to be looked for.pulmonary embolismcancer patientlow molecular weight heparinwarfarinтромбоэмболия легочной артериионкологический пациентнизкомолекулярный гепаринварфарин[1. Sciacca FL, Ciusani E, Silvani A, Corsini E, Frigerio S, Pogliani S, Parati E, Croci D, Boiardi A, Salmaggi A. Genetic and plasma markers of venous thromboembolism in patients with high grade glioma. Clin Cancer Res. 2004;10(4):1312–7.][2. Vlenterie M, Desar IM, van Herpen CM, Tol J. 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